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Evaluating the Effect of the JUUL2 System With 5 Flavors on Cigarette Smoking and Tobacco Product Use Behaviors Among Adults Who Smoke Cigarettes: 6-Week Actual Use Study

Evaluating the Effect of the JUUL2 System With 5 Flavors on Cigarette Smoking and Tobacco Product Use Behaviors Among Adults Who Smoke Cigarettes: 6-Week Actual Use Study

The study was prospectively powered for its primary aim, to evaluate rates of the past-30-day switching using the Clopper-Pearson exact method [23] with an estimated expected switch rate of 20% (based on switch rates observed in a prior observational study of US adults who purchased JUUL products), achieving a CI of 5%. Power analyses were not conducted for the secondary analyses.

Nicholas I Goldenson, Saul Shiffman, Mark A Sembower, Arielle Selya, Steve Pype, Ryan A Black

Interact J Med Res 2025;14:e60620