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A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial

A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial

If a participant refuses participation, no further contact will be made. If signed informed consent forms are completed, a note will be made in the Edward Hines Jr VA Hospital electronic medical record (EMR), and the original consent form will be kept in a locked cabinet in a locked research office behind swipe-access doors. Copies of the signed consent forms will be provided to the Edward Hines Jr VA Hospital IRB office. In addition, a copy will be provided to the participant.

Amy A Herrold, Alexandra L Aaronson, Dulal Bhaumik, Timothy Durazzo, Sherri L Livengood, Alma Ramic, Patrick Riordan, Neil Jordan, Todd Parrish, Trudy Mallinson, Ibuola O Kale, Andrea Billups, Kelly Krese, Sandra Kletzel, Noah S Philip, Theresa L Bender Pape

JMIR Res Protoc 2025;14:e64909

Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

Daily diaries are a special form of ESM in which assessments only occur once per day, typically within a prespecified time window [8]. There is evidence that digital phenotyping data can correlate with, classify, and predict mental health problems including depression and anxiety [10-17]. To our knowledge, no previous studies have linked newly collected smartphone-based digital phenotyping data with existing genetic data in mental health research.

Joanne R Beames, Omar Dabash, Michael J Spoelma, Artur Shvetcov, Wu Yi Zheng, Aimy Slade, Jin Han, Leonard Hoon, Joost Funke Kupper, Richard Parker, Brittany Mitchell, Nicholas G Martin, Jill M Newby, Alexis E Whitton, Helen Christensen

JMIR Form Res 2025;9:e71377

Acceptance-Based Pre-Exposure Prophylaxis Intervention (ACTPrEP) to Engage Young Black Men Who Have Sex With Men in the Southern United States: Protocol for a Pilot Randomized Controlled Trial

Acceptance-Based Pre-Exposure Prophylaxis Intervention (ACTPrEP) to Engage Young Black Men Who Have Sex With Men in the Southern United States: Protocol for a Pilot Randomized Controlled Trial

While there has been a 34% decrease in new HIV infections among young men who have sex with men, decreases are not equitable among ethnic groups [10]. Young Black men who have sex with men had a 27% decrease, while young White men who have sex with men had a 45% decrease [10].

Trisha Arnold, Kayla K Giorlando, Andrew P Barnett, Brandon A Gaudiano, Cara M Antonaccio, A Rani Elwy, Precious Patrick Edet, Lori M Ward, Laura Whiteley, Sarah Bailey, Brooke G Rogers, Avery Leigland, Jack C Rusley, Larry K Brown

JMIR Res Protoc 2025;14:e65921

Designing Clinical Decision Support Systems (CDSS)—A User-Centered Lens of the Design Characteristics, Challenges, and Implications: Systematic Review

Designing Clinical Decision Support Systems (CDSS)—A User-Centered Lens of the Design Characteristics, Challenges, and Implications: Systematic Review

Key findings and challenges: Insights related to the design and evaluation of the CDSS, including notable outcomes, usability concerns, and implementation barriers. Discrepancies between the 2 researchers were discussed and resolved collaboratively. Where consensus could not be reached, a third researcher (MV) was consulted for adjudication.

Andrew A Bayor, Jane Li, Ian A Yang, Marlien Varnfield

J Med Internet Res 2025;27:e63733

User Experiences With Digital Future-Self Interventions in the Contexts of Smoking and Physical Inactivity: Mixed Methods Multistudy Exploration

User Experiences With Digital Future-Self Interventions in the Contexts of Smoking and Physical Inactivity: Mixed Methods Multistudy Exploration

Relying on a single study risks offering a narrow or skewed viewpoint influenced by the specific FSI examined. Therefore, this multistudy paper triangulates behavioral, cognitive, and affective user experiences across several digital FSIs aimed at facilitating smoking cessation or PA promotion to offer a more comprehensive overview.

Kristell M Penfornis, Nele Albers, Willem-Paul Brinkman, Mark A Neerincx, Andrea WM Evers, Winifred A Gebhardt, Eline Meijer

JMIR Form Res 2025;9:e63893

Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study

Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study

The definition for a buprenorphine episode is a period in which the patient never went more than 60 days without an active buprenorphine prescription. We only included buprenorphine formulations that were for treating OUD, excluding those used only to treat pain. We did not require patients to have a diagnosis for OUD to be included in the cohort. Second, we identified patients with fills for chronic opioid analgesic therapy.

Samuel T Savitz, Maria A Stevens, Bidisha Nath, Gail D'Onofrio, Edward R Melnick, Molly M Jeffery

JMIR Form Res 2025;9:e66596

Development of Machine Learning–Based Risk Prediction Models to Predict Rapid Weight Gain in Infants: Analysis of Seven Cohorts

Development of Machine Learning–Based Risk Prediction Models to Predict Rapid Weight Gain in Infants: Analysis of Seven Cohorts

World Health Organization (WHO) global estimates indicate that a high prevalence of overweight and obesity is already evident in children younger than 5 years, with 37 million cases being reported in 2022 [3]. The WHO has thus recognized “Lowering the prevalence of overweight in children under the age of five” as one of the key outcome targets in the acceleration plan to stop obesity [4].

Miaobing Zheng, Yuxin Zhang, Rachel A Laws, Peter Vuillermin, Jodie Dodd, Li Ming Wen, Louise A Baur, Rachael Taylor, Rebecca Byrne, Anne-Louise Ponsonby, Kylie D Hesketh

JMIR Public Health Surveill 2025;11:e69220

Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Primary objectives To assess the effect of a systems navigator–facilitated HIV prevention package on preexposure prophylaxis (Pr EP) persistence among heterosexual men seeking sexually transmitted infection (STI) clinical services in Lilongwe, Malawi at 26 weeks. To assess acceptability and barriers to implementing a systems navigator–delivered HIV prevention package among key stakeholders in the clinic and heterosexual men initiating Pr EP at STI clinics. 2.

Sarah E Rutstein, Laura Limarzi-Klyn, Jane S Chen, Yaw O Agyei, Shahnaz Ahmed, Ian Bell, Myron Cohen, Jessica M Fogel, Vivian Go, Dan Haines, Erica L Hamilton, Irving F Hoffman, Mina C Hosseinipour, Mark A Marzinke, William C Miller, Mathews Mukatipa, Julie Pulerwitz, Hans M L Spiegel, Ting Ye, Mitch Matoga

JMIR Res Protoc 2025;14:e72981

Evaluating Effectiveness of mHealth Apps for Older Adults With Diabetes: Meta-Analysis of Randomized Controlled Trials

Evaluating Effectiveness of mHealth Apps for Older Adults With Diabetes: Meta-Analysis of Randomized Controlled Trials

The process involves thorough searches to identify relevant articles for statistical analysis, aiming to minimize bias and ensure a true representation of available research. The development of m Health apps involves a substantial undertaking, requiring a significant allocation of resources, which is also true for researchers conducting randomized controlled trials (RCTs).

Renato Ferreira Leitao Azevedo, Michael Varzino, Erika Steinman, Wendy A Rogers

J Med Internet Res 2025;27:e65855

Applying the Nonadoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Adapt the CHAMP App for Pediatric Feeding Tube Weaning: Application and Case Report

Applying the Nonadoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Adapt the CHAMP App for Pediatric Feeding Tube Weaning: Application and Case Report

Each domain has a set of questions to answer and review in a mixed-methods approach from primary or secondary data sources, expert knowledge, and interviews with key stakeholders [10]. Each domain is categorized by (1) simple: straightforward, predictable, and have few components, (2) complicated: multiple interacting components or issues, or (3) complex: dynamic, unpredictable, and prove difficult to disaggregate into constituent components [11].

Dana M Bakula, Alexandra Zax, Sarah Edwards, Kristina Nash, April Escobar, Rachel Graham, Amy Ricketts, Ryan Thompson, Sarah Bullard, Julianne Brogren, Leah Shimmens, Lori A Erickson

JMIR Form Res 2025;9:e67398