Randomized trials (Editor: G. Eysenbach)*

Impact of a Symptom Checker App on Patient-Physician Interaction Among Self-Referred Walk-In Patients in the Emergency Department: Multicenter, Parallel-Group, Randomized, Controlled Trial

Malte L Schmieding, Marvin Kopka, Myrto Bolanaki, Hendrik Napierala, Maria B Altendorf, Doreen Kuschick, Sophie K Piper, Lennart Scatturin, Konrad Schmidt, Claudia Schorr, Alica Thissen, Cornelia Wäscher, Christoph Heintze, Martin Möckel, Felix Balzer, Anna Slagman

J Med Internet Res 2025 (Apr 02); 27:e64028

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Design and Baseline Evaluation of Social Media Vaping Prevention Trial: Randomized Controlled Trial Study

William Douglas Evans, Megumi Ichimiya, Jeffrey B Bingenheimer, Jennifer Cantrell, Alexander P D'Esterre, Olivia Pincus, Linda Q Yu, Elizabeth C Hair

J Med Internet Res 2025 (Mar 31); 27:e72002

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Effectiveness of the Safe Step Digital Exercise Program to Prevent Falls in Older Community-Dwelling Adults: Randomized Controlled Trial

Beatrice Pettersson, Lillemor Lundin-Olsson, Dawn A Skelton, Per Liv, Magnus Zingmark, Erik Rosendahl, Marlene Sandlund

J Med Internet Res 2025 (Mar 31); 27:e67539

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Acceptability and Effectiveness of a Fully Web-Based Nutrition and Exercise Program for Individuals With Chronic Disease During COVID-19: Randomized Controlled Trial

Puneeta Tandon, Kathleen P Ismond, Graeme Purdy, Christofer Cruz, Evelyn Etruw, Kirsten Suderman, Ashley Hyde, Michael Stickland, John C Spence, Dale C Lien, Rahima Bhanji, Carla M Prado, Antonio Miguel-Cruz, Anil A Joy, Maryna Yaskina, Margaret L McNeely

J Med Internet Res 2025 (Mar 24); 27:e57537

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Authors’ Response to Peer Reviews of “Large Language Models for Pediatric Differential Diagnoses in Rural Health Care: Multicenter Retrospective Cohort Study Comparing GPT-3 With Pediatrician Performance”

Masab Mansoor, Andrew F Ibrahim, David Grindem, Asad Baig

JMIRx Med 2025 (Mar 19); 6:e73258

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Alternative Presentations of Overall and Statistical Uncertainty for Adults’ Understanding of the Results of a Randomized Trial of a Public Health Intervention: Parallel Web-Based Randomized Trials

Christine Holst, Steven Woloshin, Andrew D Oxman, Christopher Rose, Sarah Rosenbaum, Heather Menzies Munthe-Kaas

JMIR Public Health Surveill 2025 (Mar 18); 11:e62828

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Optimizing Engagement With a Smartphone App to Prevent Violence Against Adolescents: Results From a Cluster Randomized Factorial Trial in Tanzania

Roselinde Janowski, Lucie D Cluver, Yulia Shenderovich, Joyce Wamoyi, Mwita Wambura, David Stern, Lily Clements, G J Melendez-Torres, Lauren Baerecke, Abigail Ornellas, Angelique Nicole Chetty, Jonathan Klapwijk, Laetitia Christine, Ateamate Mukabana, Esmee Te Winkel, Anna Booij, Gervas Mbosoli, Jamie M Lachman

J Med Internet Res 2025 (Mar 10); 27:e60102

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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial

Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

J Med Internet Res 2025 (Jan 31); 27:e59946

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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial

Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

J Med Internet Res 2025 (Jan 21); 27:e56039

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Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial

Nicholas Leung, Kayo Waki, Satoshi Nozoe, Shunpei Enomoto, Ryo Saito, Sakurako Hamagami, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe, Yukiko Onishi

J Med Internet Res 2024 (Sep 10); 26:e53740

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Association of Remote Patient-Reported Outcomes and Step Counts With Hospitalization or Death Among Patients With Advanced Cancer Undergoing Chemotherapy: Secondary Analysis of the PROStep Randomized Trial

Christopher R Manz, Emily Schriver, William J Ferrell, Joelle Williamson, Jonathan Wakim, Neda Khan, Michael Kopinsky, Mohan Balachandran, Jinbo Chen, Mitesh S Patel, Samuel U Takvorian, Lawrence N Shulman, Justin E Bekelman, Ian J Barnett, Ravi B Parikh

J Med Internet Res 2024 (May 17); 26:e51059

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The Effect of Interactivity, Tailoring, and Use Intensity on the Effectiveness of an Internet-Based Smoking Cessation Intervention Over a 12-Month Period: Randomized Controlled Trial

Phillip Maiwald, Martina Bischoff, Peter Lindinger, Iris Tinsel, Matthias Sehlbrede, Urs Alexander Fichtner, Gloria Metzner, Christian Schlett, Erik Farin-Glattacker

J Med Internet Res 2023 (Nov 21); 25:e47463

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Effectiveness of a Theory-Based Digital Animated Video Intervention to Reduce Intention and Willingness to Sext Among Diploma Students: Cluster Randomized Controlled Trial

Norain Mansor, Norliza Ahmad, Salmiah Md Said, Kit-Aun Tan, Rosnah Sutan

J Med Internet Res 2023 (Oct 20); 25:e48968

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Stop and Play Digital Health Education Intervention for Reducing Excessive Screen Time Among Preschoolers From Low Socioeconomic Families: Cluster Randomized Controlled Trial

Diana Raj, Norliza Ahmad, Nor Afiah Mohd Zulkefli, Poh Ying Lim

J Med Internet Res 2023 (May 04); 25:e40955

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Efficacy of Web-Based, Guided Self-help Cognitive Behavioral Therapy–Enhanced for Binge Eating Disorder: Randomized Controlled Trial

Bernou Melisse, Elske van den Berg, Margo de Jonge, Matthijs Blankers, Eric van Furth, Jack Dekker, Edwin de Beurs

J Med Internet Res 2023 (May 01); 25:e40472

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Electronic Health Record–Nested Reminders for Serum Lithium Level Monitoring in Patients With Mood Disorder: Randomized Controlled Trial

Tomotsugu Seki, Morio Aki, Toshi A Furukawa, Hirotsugu Kawashima, Tomotaka Miki, Yujin Sawaki, Takaaki Ando, Kentaro Katsuragi, Takahiko Kawashima, Senkei Ueno, Takashi Miyagi, Shun'ichi Noma, Shiro Tanaka, Koji Kawakami

J Med Internet Res 2023 (Mar 22); 25:e40595

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Effects of Fetal Images Produced in Virtual Reality on Maternal-Fetal Attachment: Randomized Controlled Trial

Kyong-No Lee, Hyeon Ji Kim, Kiroong Choe, Aeri Cho, Bohyoung Kim, Jinwook Seo, Woojae Myung, Jee Yoon Park, Kyung Joon Oh

J Med Internet Res 2023 (Feb 24); 25:e43634

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Evaluating the Effects of the Supportive Parenting App on Infant Developmental Outcomes: Longitudinal Study

Shefaly Shorey, Yap Seng Chong, Luming Shi, Jing Shi Chua, Thilagamangai, Jancy Mathews, Siew Hoon Lim, Ruochen Du, Yiong Huak Chan, Thiam Chye Tan, Cornelia Chee, Evelyn Law

JMIR Mhealth Uhealth 2023 (Feb 22); 11:e43885

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A New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study

Katell Le Du, Anne-Lise Septans, Frédéric Maloisel, Hélène Vanquaethem, Anna Schmitt, Marielle Le Goff, Aline Clavert, Marie Zinger, Hugues Bourgeois, Olivier Dupuis, Fabrice Denis, Stéphane Bouchard

J Med Internet Res 2023 (Feb 15); 25:e38619

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Evaluating the Effectiveness of the Supportive Parenting App on Parental Outcomes: Randomized Controlled Trial

Shefaly Shorey, Evelyn Law, Thilagamangai, Jancy Mathews, Siew Hoon Lim, Luming Shi, Jing Shi Chua, Ruochen Du, Yiong Huak Chan, Thiam Chye Tan, Cornelia Chee, Yap Seng Chong

J Med Internet Res 2023 (Jan 16); 25:e41859

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