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Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

There is evidence that digital phenotyping data can correlate with, classify, and predict mental health problems including depression and anxiety [10-17]. To our knowledge, no previous studies have linked newly collected smartphone-based digital phenotyping data with existing genetic data in mental health research.

Joanne R Beames, Omar Dabash, Michael J Spoelma, Artur Shvetcov, Wu Yi Zheng, Aimy Slade, Jin Han, Leonard Hoon, Joost Funke Kupper, Richard Parker, Brittany Mitchell, Nicholas G Martin, Jill M Newby, Alexis E Whitton, Helen Christensen

JMIR Form Res 2025;9:e71377

Impact of Virtual Reality–Based Biofeedback on Sleep Quality Among Individuals With Depressive Symptoms, Anxiety Symptoms, or Both: 4-Week Randomized Controlled Study

Impact of Virtual Reality–Based Biofeedback on Sleep Quality Among Individuals With Depressive Symptoms, Anxiety Symptoms, or Both: 4-Week Randomized Controlled Study

In the United States, 84.7% of individuals with major depressive disorder (MDD) have reported sleep difficulties associated with higher depression severity scores [1]. Previous studies have demonstrated that poor sleep can significantly affect mental health and daily functioning, linking it to worsened mental health and reduced socio-occupational performance with serious mental illness [2-4].

Sisu Seong, Hyewon Kim, Yaehee Cho, Min-Ji Kim, Ka Ram Park, Jooeun Choi, Seonah Lee, Dong Jun Kim, Seog Ju Kim, Hong Jin Jeon

J Med Internet Res 2025;27:e65772

Digital Phenotyping for Detecting Depression Severity in a Large Payor-Provider System: Retrospective Study of Speech and Language Model Performance

Digital Phenotyping for Detecting Depression Severity in a Large Payor-Provider System: Retrospective Study of Speech and Language Model Performance

Most of the research examining digital phenotyping for the detection of BH problems has focused on detection of depression [10]. The opportunity to engage passive and objective ML technology for better detecting depression presents particular opportunities in light of the fact that depression is undetected in approximately 50% of individuals with the condition in high-income countries, and in 80%‐90% of individuals with depression in low- and middle-income countries [11].

Bradley Karlin, Doug Henry, Ryan Anderson, Salvatore Cieri, Michael Aratow, Elizabeth Shriberg, Michelle Hoy

JMIR AI 2025;4:e69149

Designing Chatbots to Treat Depression in Youth: Qualitative Study

Designing Chatbots to Treat Depression in Youth: Qualitative Study

We conducted semistructured interviews to explore participants’ experiences with depression, their adaptive coping strategies, attitudes and expectations toward chatbots for depression, and their design preferences. Finally, the participants interacted with a prototype chatbot using the concurrent think-aloud method. We conducted a semistructured interview to evaluate participants’ eligibility to participate in the study.

Florian Onur Kuhlmeier, Luise Bauch, Ulrich Gnewuch, Stefan Lüttke

JMIR Hum Factors 2025;12:e66632

Investigating Project Care UK, a Web-Based Self-Help Single-Session Intervention for Youth Mental Health: Program Evaluation

Investigating Project Care UK, a Web-Based Self-Help Single-Session Intervention for Youth Mental Health: Program Evaluation

Adolescence is a critical period of marked physical, cognitive, social, and emotional development [1], during which psychological distress (eg, depression and anxiety) becomes increasingly common [2]. However, many adolescents will never access treatments [3,4]. In the United Kingdom, a large-scale school-based survey study found that approximately one-third of adolescents had a perceived unmet need for mental health help [5].

Maria Elizabeth Loades, Grace Perry, Noah Marshall

JMIR Ment Health 2025;12:e72077

Evaluating a Mobile Digital Therapeutic for Vasomotor and Behavioral Health Symptoms Among Women in Midlife: Randomized Controlled Trial

Evaluating a Mobile Digital Therapeutic for Vasomotor and Behavioral Health Symptoms Among Women in Midlife: Randomized Controlled Trial

The PHQ-8 is an 8-item self-reported questionnaire that measures current depression [44]. It is well validated as a diagnostic measure across clinical studies. Scores for each item range from 0 to 3, and total scores are calculated by summing the 8 items and can range from 0 to 24. Higher scores equate to higher depression. Scores of 10 or greater are considered clinically significant. The PHQ-8 is considered to be a reliable and valid measure for screening depression in the general population [45].

Jennifer Duffecy, Arfa Rehman, Scott Gorman, Yong Lin Huang, Heide Klumpp

JMIR Mhealth Uhealth 2025;13:e58204

Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis

Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis

The review concluded that i BA interventions showed promise to be as effective as traditional face-to-face methods at reducing various forms of depression including subthreshold depression, postpartum depression, and depression with comorbid chronic conditions like diabetes.

Eric Jia, Jushawn Macon, Michelle Doering, Joanna Abraham

J Med Internet Res 2025;27:e68054

Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis

Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis

Therefore, based on these conflicting research results, we conducted a meta-analysis to clarify the clinical efficacy of remote web-based interventions on the physiological (pain and fatigue) and psychological (anxiety and depression) states and the quality of life of patients with cancer.

Lv Tian, Yixuan Wen, Jingmiao Li, Jiexin Guan, Tao Li, Jun Fan

JMIR Mhealth Uhealth 2025;13:e71196

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Adolescent depression is a significant mental health crisis; 14.7% of the adolescent population reports at least one major depressive episode with severe impairment [1]. This trend predates the COVID-19 pandemic [2] and has continued apace [3]. The impact of adolescent depression is severe; a depressive episode leads to immediate debilitating effects plus long-term consequences [4], for example, impaired academic performance [5] and challenges in forming interpersonal relationships [6].

Jimena Unzueta Saavedra, Emma A Deaso, Margot Austin, Laura Cadavid, Rachel Kraff, Emma E M Knowles

JMIR Form Res 2025;9:e66187

Impacts of the Mindfulness Meditation Mobile App Calm on Undergraduate Students’ Sleep and Emotional State: Pilot Randomized Controlled Trial

Impacts of the Mindfulness Meditation Mobile App Calm on Undergraduate Students’ Sleep and Emotional State: Pilot Randomized Controlled Trial

The mean state depression scores pretreatment were similar in the control and treatment groups (P=.58) and represented moderate severity state depression at baseline in both groups. The mean state anxiety scores at baseline were also similar between the control and treatment groups (P=.11), however, scores represented moderate-severity state anxiety in the control group and severe state anxiety in the treatment group.

Tovan Lew, Natnaiel M Dubale, Erik Doose, Alex Adenuga, Holly E Bates, Sarah L West

JMIR Form Res 2025;9:e66131