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For study inclusion, students had to be in their preclinical years of the school’s Doctor of Medicine program; else, they were excluded. A convenience sample of 30 responses (23 and 7 responses from first-year and second-year medical students, respectively) was collected (Table 1).
JMIR Form Res 2025;9:e73394
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The pressure to choose and prepare for a specialty so early in medical school may explain the neuroticism and stress found in preclinical participants, highlighting the need for early experiences with specialties, so that students can select their field and begin tailoring their activities as early as possible.
JMIR Form Res 2025;9:e73507
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Melatonin for Neuropathic Pain: Protocol for a Double-blind, Randomized Controlled Trial
Relevant to pain, accumulating preclinical and clinical evidence suggests antinociceptive effects of melatonin by acting on MT1 and MT2 membrane receptors (to reduce cyclic AMP) but possibly also (1) by indirectly activating opioid receptors, (2) by inhibiting the production of proinflammatory cytokines, (3) by activating γ-aminobutyric acid-A receptors, and (4) through its antioxidant effects [14].
JMIR Res Protoc 2022;11(9):e40025
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Drill-Hole Bone Defects in Animal Models of Bone Healing: Protocol for a Systematic Review
Therefore, the purpose of this systematic review is to present a narrative synthesis of the different animal models of long bone drill-hole bone defects and their potential use in preclinical and translational research.
JMIR Res Protoc 2022;11(7):e34887
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