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Honey as a Wound Care Modality in Treating Deep Neck Space Abscesses: Protocol for a Randomized Controlled Trial

Honey as a Wound Care Modality in Treating Deep Neck Space Abscesses: Protocol for a Randomized Controlled Trial

The mechanistic action of honey in wound healing has been widely hypothesized; however, no one has evaluated its effect clinically, systemically, or on the proinflammatory cytokines and growth factors that play a role in each phase of wound healing. Thus, this study will conduct a clinical trial of honey as one of the modalities in the treatment of deep neck abscess wounds.

Dian Paramita Wulandari, Yanri Wijayanti Subronto, Agus Surono

JMIR Res Protoc 2025;14:e75475

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Predicting Transvaginal Surgical Mesh Exposure Outcomes Using an Integrated Dataset of Blood Cytokine Levels and Medical Record Data: Machine Learning Approach

Predicting Transvaginal Surgical Mesh Exposure Outcomes Using an Integrated Dataset of Blood Cytokine Levels and Medical Record Data: Machine Learning Approach

Similarly, Chowdhury et al [8] applied biomarkers, such as mucus cytokines, along with patient demographics and clinical characteristics to machine learning algorithms to predict chronic rhinosinusitis improvement when treated with endoscopic sinus surgery.

Mihyun Lim Waugh, Tyler Mills, Nicholas Boltin, Lauren Wolf, Patti Parker, Ronnie Horner, Thomas L Wheeler II, Richard L Goodwin, Melissa A Moss

JMIR Form Res 2025;9:e59631

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Prediction of Pelvic Organ Prolapse Postsurgical Outcome Using Biomaterial-Induced Blood Cytokine Levels: Machine Learning Approach

Prediction of Pelvic Organ Prolapse Postsurgical Outcome Using Biomaterial-Induced Blood Cytokine Levels: Machine Learning Approach

In addition, supervised machine learning models were applied to demonstrate predictive capabilities when models were trained with either all 13 cytokines or a smaller group of 7 cytokines determined most effective by a random forest method.

Mihyun Lim Waugh, Nicholas Boltin, Lauren Wolf, Jane Goodwin, Patti Parker, Ronnie Horner, Matthew Hermes, Thomas Wheeler, Richard Goodwin, Melissa Moss

JMIR Perioper Med 2023;6:e40402

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The Effects of HIV Infection on the Immune Response to Malaria Among Pregnant Women in Kumba, Southwest Cameroon: Protocol for a Cross-sectional Study

The Effects of HIV Infection on the Immune Response to Malaria Among Pregnant Women in Kumba, Southwest Cameroon: Protocol for a Cross-sectional Study

Djontu et al [14] revealed that placental malaria reduces maternal plasma levels of cytokines IL-17 E, IL-27, and IL-28 A, as well as neonatal plasma levels of cytokines IL-17 E and IL-28 A, which may aid in parasite clearance and enhance infant birth weight. IL-27 and IL-6 are 2 cytokines that can have both pro-inflammatory and anti-inflammatory actions. Indeed, IL-27 has been shown to activate the T-bet transcription factor, which promotes helper T (Th)1 cell differentiation [15,16].

Bekindaka Ngemani Obase, Zeukeng Francis, Esemu Livo Forgu, Awanakam Honore, Jude Daiga Bigoga, Dickson S Nsagha

JMIR Res Protoc 2023;12:e38213

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Modulation of Bone and Joint Biomarkers, Gut Microbiota, and Inflammation Status by Synbiotic Supplementation and Weight-Bearing Exercise: Human Study Protocol for a Randomized Controlled Trial

Modulation of Bone and Joint Biomarkers, Gut Microbiota, and Inflammation Status by Synbiotic Supplementation and Weight-Bearing Exercise: Human Study Protocol for a Randomized Controlled Trial

Elevated levels of proinflammatory cytokines (eg, interleukin [IL]–6, tumor necrosis factor [TNF]-α, IL-1, and receptor activator of nuclear factor kappa-Β ligand produced by activated T cells) induce osteoclast formation and activity during senescence [2,6].

Bolaji Lilian Ilesanmi-Oyelere, Nicole C Roy, Marlena C Kruger

JMIR Res Protoc 2021;10(10):e30131

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