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Impact of 12-Month mHealth Home Telemonitoring on Clinical Outcomes in Older Individuals With Hypertension and Type 2 Diabetes: Multicenter Randomized Controlled Trial

Impact of 12-Month mHealth Home Telemonitoring on Clinical Outcomes in Older Individuals With Hypertension and Type 2 Diabetes: Multicenter Randomized Controlled Trial

Consequently, rather than calculating the sample size required to demonstrate a clinically significant reduction (10 mm Hg in SBP and 0.5% in Hb A1c), we determined the minimum detectable difference between groups based on this planned sample size [4].

Matic Mihevc, Majda Mori Lukančič, Črt Zavrnik, Tina Virtič Potočnik, Nina Ružić Gorenjec, Marija Petek Šter, Zalika Klemenc-Ketiš, Antonija Poplas Susič

JMIR Mhealth Uhealth 2025;13:e59733

Effects of Using a Digital Peer-Supported App on Glycated Hemoglobin Changes Among Patients With Type 2 Diabetes: Prospective Single-Arm Pilot Study

Effects of Using a Digital Peer-Supported App on Glycated Hemoglobin Changes Among Patients With Type 2 Diabetes: Prospective Single-Arm Pilot Study

Glycated hemoglobin (Hb A1c) is the gold standard for measuring average blood glucose levels over 3 months and predicting the relative risk of diabetes complications [3,4]. A previous study revealed that adopting healthy behaviors (ie, maintaining a healthy body weight, following a healthy diet, exercising, avoiding smoking, and avoiding drinking alcohol) is an effective strategy for controlling Hb A1c levels in patients with T2 DM [5].

Shota Yoshihara, Kayoko Takahashi, Hiroyuki Kawaguchi, Nozomi Harai, Kyoichiro Tsuchiya

JMIR Form Res 2025;9:e72659

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Unique barriers to diabetes medication adherence have been reported by Latino adults with T2 D [8-18], including negative perceptions regarding diabetes medication use (particularly insulin) [9,12,18], misunderstanding of the ongoing need for glucose-lowering pharmacotherapy once glycated hemoglobin (Hb A1c) has improved [17], and challenges with regimen complexity even with the use of a Spanish-language interpreter [8,19].

Jacqueline Seiglie, Seth Tobolsky, Ricaurte Crespo Trevino, Lluvia Cordova, Sara Cromer, A Enrique Caballero, Margarita Alegria, J Jaime Miranda, Deborah Wexler, Lindsay Mayberry

JMIR Hum Factors 2025;12:e66668

Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis

Effect of Multimodal App-Based Interventions on Glycemic Control in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis

Hemoglobin A1c (Hb A1c; long-term blood glucose) levels were also significantly reduced with 56.1% of participants achieving a Hb A1c value of Blood glucose control is a key target for such interventions, to lower cardiovascular risk as well as mortality from T2 DM [5]. In adults with T2 DM, the Hb A1c target value is set individually, depending on various factors, such as diabetes duration, comorbidities, and patient preference, but it lies within the corridor of 6.5%-8.5% [10].

Emma Bodner, Lena Roth, Kathleen Wiencke, Christian Bischoff, Peter EH Schwarz

J Med Internet Res 2025;27:e54324

Improving Self-Efficacy, Quality of Life, and Glycemic Control in Adolescents With Type 1 Diabetes: Randomized Controlled Trial for the Evaluation of the Family-Centered Empowerment Model

Improving Self-Efficacy, Quality of Life, and Glycemic Control in Adolescents With Type 1 Diabetes: Randomized Controlled Trial for the Evaluation of the Family-Centered Empowerment Model

One possibility of results of this type of study indicates that the use of family-focused models in diabetes treatment may not only improve clinical measures, including glycosylated hemoglobin (Hb A1c), but also dramatically influence psychosocial health. Family-centered interventions are medical strategies that involve family members in the management and treatment of a patient’s disease.

Salah Alzawahreh, Candan Ozturk

JMIR Form Res 2024;8:e64463

Whole-Body Cryotherapy Reduces Systemic Inflammation in Healthy Adults: Pilot Cohort Study

Whole-Body Cryotherapy Reduces Systemic Inflammation in Healthy Adults: Pilot Cohort Study

Blood biomarkers measured include serum high-sensitivity C-reactive protein (hs CRP), fasting glucose, hemoglobin A1c (Hb A1c), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), and triglycerides. All blood was drawn from the median cubital vein with a 20-gauge intravenous catheter needle.

Elizabeth Chun, Richard Joseph, Rachele Pojednic

Interact J Med Res 2024;13:e60942

Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial

Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial

We set the mean difference in the change in Hb A1c from the baseline that we were designing the study to detect to 0.5, as this is generally considered a clinically significant change in Hb A1c [26,27]. The SD common to both groups was set to 1 based on values from previous studies [23,28,29], and the 2-sided significance level was 5% with 90% power. The resulting required sample size is 86 for each group.

Nicholas Leung, Kayo Waki, Satoshi Nozoe, Shunpei Enomoto, Ryo Saito, Sakurako Hamagami, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe, Yukiko Onishi

J Med Internet Res 2024;26:e53740

Outcomes of an Asynchronous Care Model for Chronic Conditions in a Diverse Population: 12-Month Retrospective Chart Review Study

Outcomes of an Asynchronous Care Model for Chronic Conditions in a Diverse Population: 12-Month Retrospective Chart Review Study

The first and last available Hb A1c results were compared among all included members, as well as in the subgroups with a baseline Hb A1c >8% (poor control group) and a baseline Hb A1c >9% (uncontrolled hyperglycemia group) using paired 2-tailed t tests.

Michael Hofner, Patrick Hurnaus, Dan DiStefano, Shaji Philip, Sarah Kim, Julie Shaw, Avantika Chander Waring

JMIR Diabetes 2024;9:e53835

Examining a Remote Group-Based Type 2 Diabetes Self-Management Education Program in the COVID-19 Era Using the ORBIT Model: Small 6-Week Feasibility Study

Examining a Remote Group-Based Type 2 Diabetes Self-Management Education Program in the COVID-19 Era Using the ORBIT Model: Small 6-Week Feasibility Study

To examine the potential impact of the program on behavioral and clinical risk factors, device-assessed (4) weekly mean daily step count and (5) estimated glycated hemoglobin (Hb A1c; the average glucose level from the Free Style Libre readings for 14 or more days [17]) were collected. Given the small, single cohort and preparatory nature of this ORBIT phase 1b feasibility study, individual and group-level data are presented descriptively rather than with inferential statistics.

Madison S Hiemstra, Sonja M Reichert, Marc S Mitchell

JMIR Form Res 2024;8:e46418