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The First 6 Years’ Experiences of a National Centralized Offspring Surveillance Setting for Dutch Children Prenatally Exposed to Maternal Cancer to Inform Future International Practice: Protocol for a Demographic Review of Referred Families and Key Lessons Learned

The First 6 Years’ Experiences of a National Centralized Offspring Surveillance Setting for Dutch Children Prenatally Exposed to Maternal Cancer to Inform Future International Practice: Protocol for a Demographic Review of Referred Families and Key Lessons Learned

Cancer during pregnancy is rare, occurring in 1 in 1000-2000 pregnant women [1]. However, this incidence is rising as women tend to delay childbearing [2]. Also, since the introduction of the Non-invasive Prenatal Testing program in the Netherlands (in 2018), maternal cancer, often asymptomatic, is detected incidentally, even before clinical symptoms appear [3]. Hence, cancer during pregnancy is an emerging health and societal challenge, which necessitates dedicated management for the mother and child.

Evangeline A Huis in 't Veld, Anouk M Kruse, Emma J Verwaaijen, Sterre C Huizer, Elisabeth M van Dijk-Lokkart, Christianne Lok, Maaike Kuethe, Frederic Amant, Mathilde M A van Gerwen, Martine van Grotel, Marry M van den Heuvel-Eibrink

JMIR Res Protoc 2025;14:e71612

Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study

In total, 1282 participants aged 18‐30 years who had provided genetic data in the AGDS were invited by the AGDS team to participate. Interested participants completed informed consent and eligibility screening. Eligibility criteria included being an Australian resident, owning an i OS smartphone, willingness to participate, and proficiency in English.

Joanne R Beames, Omar Dabash, Michael J Spoelma, Artur Shvetcov, Wu Yi Zheng, Aimy Slade, Jin Han, Leonard Hoon, Joost Funke Kupper, Richard Parker, Brittany Mitchell, Nicholas G Martin, Jill M Newby, Alexis E Whitton, Helen Christensen

JMIR Form Res 2025;9:e71377

Impact of Virtual Reality–Based Biofeedback on Sleep Quality Among Individuals With Depressive Symptoms, Anxiety Symptoms, or Both: 4-Week Randomized Controlled Study

Impact of Virtual Reality–Based Biofeedback on Sleep Quality Among Individuals With Depressive Symptoms, Anxiety Symptoms, or Both: 4-Week Randomized Controlled Study

The efficacy of VR-based BF in the DAS/VR group was compared to that of conventional BF in the DAS/BF group. In addition, the HC/VR group received VR-based BF to evaluate its effects in nonclinical populations. Participants with depressive symptoms, anxiety symptoms, or both were randomly assigned to either DAS/VR group or DAS/BF group at a 1:1 ratio using computer-generated randomized numbers.

Sisu Seong, Hyewon Kim, Yaehee Cho, Min-Ji Kim, Ka Ram Park, Jooeun Choi, Seonah Lee, Dong Jun Kim, Seog Ju Kim, Hong Jin Jeon

J Med Internet Res 2025;27:e65772

The Relationship Between Medical Student Neuroticism and Preferred Medical Specialty: Cross-Sectional Study

The Relationship Between Medical Student Neuroticism and Preferred Medical Specialty: Cross-Sectional Study

However, students interested in both surgical and medical specialties had lower neuroticism scores (t30=−2.039; P=.03) than those of students who focused on only one field. Second-year medical students reported feeling tenser (H1=4.867; P=.03) and moodier (H1=10.364; P=.001) than first-year medical students. Students interested in surgical specialties perceived their specialties as more competitive (H1=4.080; P=.04).

Jonathan Shaw, Brenton Phung, Ashley Lai, James Hagerty, Van Le, Seung Rim Yoo, Jerome Torres, Angelene Won, Charles Lai, Peter Bota, Aaron Jacobs

JMIR Form Res 2025;9:e73507

Evaluating the User Experience and Usability of Game-Based Cognitive Assessments for Older People: Systematic Review

Evaluating the User Experience and Usability of Game-Based Cognitive Assessments for Older People: Systematic Review

To be included in this review, a GBCA must have been psychometrically validated with a sample of older users (aged ≥50 years). This validation could have occurred in the same study as the user evaluation or in a previous validation of the same game. In other words, evidence of validation was a prerequisite for inclusion in this review, but validation of the game was not necessarily required within the actual studies included in this review.

Rhys Mantell, Ye In Jane Hwang, Matthew Dark, Kylie Radford, Michael Kasumovic, Lauren Monds, Peter W Schofield, Tony Butler, Adrienne Withall

JMIR Aging 2025;8:e65252

A Deep Learning Model for Identifying the Risk of Mesenteric Malperfusion in Acute Aortic Dissection Using Initial Diagnostic Data: Algorithm Development and Validation

A Deep Learning Model for Identifying the Risk of Mesenteric Malperfusion in Acute Aortic Dissection Using Initial Diagnostic Data: Algorithm Development and Validation

The VOIs, including the abdominal aorta (including the 3 main branches of the celiac trunk and the primary branches of the SMA and the IMA) and the bowel (including the jejunum, ileum, and colon), were manually labeled by a surgeon (Z Jin, reader 1) with 5 years of diagnostic experience using a 3 D Slicer. To validate annotation consistency [28], a second surgeon (YJ, reader 2) independently labeled a randomly selected subset (n=30) of images.

Zhechuan Jin, Jiale Dong, Chengxiang Li, Yi Jiang, Jian Yang, Lei Xu, Ping Li, Zhun Xie, Yulin Li, Dongjin Wang, Zhili Ji

J Med Internet Res 2025;27:e72649

Smart Technology Facilitated Patient-Centered Venous Thromboembolism Management (the SmaVTE Study): Protocol for a Randomized Controlled Trial

Smart Technology Facilitated Patient-Centered Venous Thromboembolism Management (the SmaVTE Study): Protocol for a Randomized Controlled Trial

Our study is scheduled to commence in August 2024 and conclude in November 2025. Recruitment began in August 2024 and is anticipated to conclude by June 2025. Data analysis is planned to commence in October 2025 after the follow-up data collection. The analysis is expected to be completed by November 2025. The protocol conforms to the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 statement [37]. The latest protocol (version 1.0) was dated March 1, 2024.

Zhi-Geng Jin, Zhe-Qi Zhang, Bin-Bin Liu, Hao Wang, Ying Yang, Li-Na Ren, Hui Zhang, Wei Ji, Zhen-Guo Zhai, Yu-Tao Guo

JMIR Res Protoc 2025;14:e67254

Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study

Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study

Meaning and purpose in life were associated with cognitive decline, and incident MCI and Alzheimer disease in prior studies [25]. In addition, studies investigating volunteering interventions to provide meaningful social, physical, and cognitive activities for older adults reduced brain aging [26].

Chava Pollak, Helena M Blumen, Lily Zhou, Jennifer Wong, Ying Jin, Atul Bhattiprolu, Sophie Anfang, Mirnova E Ceïde

JMIR Res Protoc 2025;14:e70518

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

Scaling a Brief Digital Well-Being Intervention (the Big Joy Project) and Sociodemographic Moderators: Single-Group Pre-Post Study

(Takes approximately 10 min) Tune in to what matters. This prompted people to rank 4 values (virtue, fairness, goodwill, and unity) in order of importance and then write about how the values appear in their life. (Takes approximately 10 min) Make a gratitude list. This prompted people to think, reflect, and list up to 8 things or people they feel grateful for. (Takes approximately 10 min) Dwell in awe.

Darwin A Guevarra, Yoobin Park, Xuhai Xu, Jin Liou, Jolene Smith, Peggy Callahan, Emiliana Simon-Thomas, Elissa S Epel

J Med Internet Res 2025;27:e72053

Internet-Based Interventions for Preventing Premature Birth in Preconceptional Women of Childbearing Age: Systematic Review

Internet-Based Interventions for Preventing Premature Birth in Preconceptional Women of Childbearing Age: Systematic Review

This systematic review was reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines [19] (checklist in Multimedia Appendix 3) and was registered in PROSPERO (International Prospective Register of Systematic Reviews; CRD42021277024).

Sun-Hee Kim, Sun-Young Jung, Jin-Hwa Park, Jennie C De Gagne

J Med Internet Res 2025;27:e60690