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Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial

Treatment of Erythematotelangiectatic Rosacea With Collateral Puncture Therapy: Protocol for a Randomized Controlled Trial

With reference to relevant literature, we used a noninferiority trial calculation formula for sample size calculation, as follows: n1=[(u1-T+u1-u)e/W]2×(1+c)/c, n2=cn1 [28] In the formula, where c=1, n2=n1; setting α=.05, then u1–T=1.64, u1–u=1.28. Based on previous studies using clinician erythema assessment scoring as the primary efficacy end point, e is taken as 0.84, W as 1. Substituting the data into the formula, we calculate n1=n2≈13 [29].

Aolin Song, Bingnan Cui, Xuemin Wang, Jianing Bi, Xiaohong Wu, Liu Yang, Li Liu, Shengyuan Qu, Zhu Fan, Jiao Yang, Yuhe Yan

JMIR Res Protoc 2025;14:e59682