Interpretable Machine Learning Framework for Predicting Major Adverse Cardiovascular Events in Rheumatoid Arthritis Using Electronic Health Records: Multicenter Cohort Study

Wei-Chen Chiang   ¹ , MS ;   Guan-Ling Lin   ¹ , PhD ;   Yu-Sheng Chang   ^{2, 3} , MD ;   Yu-Chen Liu   ^{1, 4} , PhD ;   Chih-Wei Huang   ^{1, 5} , PhD ;   Phung Anh Nguyen   ^{6, 7, 8, 9} , PhD ;   Jason C Hsu   ^{7, 8, 9, 10} , PhD ;   Der-Ming Liou   ¹¹ , PhD ;   Hsuan-Chia Yang   ^{1, 5, 7, 12} , PhD

¹ Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, New Taipei, Taiwan

² Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan

³ Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Ministry of Health and Welfare, Taipei, Taiwan

⁴ School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan

⁵ International Center for Health Information and Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

⁶ Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei, Taiwan

⁷ Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, Taiwan

⁸ Research Center of Healthcare Industry Data Science, College of Management, Taipei Medical University, Taipei, Taiwan

⁹ Clinical Data Center, Office of Data Science, Taipei Medical University, Taipei, Taiwan

¹⁰ International PhD Program in Biotech and Healthcare Management, College of Management, Taipei Medical University, Taipei, Taiwan

¹¹ Master Program in Medical Informatics, National Tsing Hua University, Hsinchu, Taiwan

¹² Research Center of Big Data and Meta-Analysis, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan