Accessibility settings

Published on in Vol 10 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/89830, first published .
Elderly man with white beard assembling a jigsaw puzzle, with a woman's hands on his shoulders.

Remote Identification of APOE-ε4 Carrier Status in Cognitively Normal Adults via Speech Acoustics: Cross-Sectional Observational Study

Remote Identification of APOE-ε4 Carrier Status in Cognitively Normal Adults via Speech Acoustics: Cross-Sectional Observational Study

Maryam Tavakoli   1 * , PhD ;   Mehrdad Dadgostar   1, 2 * , PhD ;   Jordan R Green   1, 3 , PhD ;   David H Salat   2, 4, 5 , PhD ;   Steven E Arnold   2, 6 , MD ;   Kathryn P Connaghan   1 , PhD ;   Brian Richburg   1 , BA ;   Nelson V Barnett   1 , BSc ;   Mariam Tkeshelashvili   1 , BSN ;   Marziye Eshghi   1, 2, 4 , PhD

1 Mass General Brigham University of Health Professions, Charlestown, MA, United States

2 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

3 Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA, United States

4 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

5 Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Jamaica Plain, MA, United States

6 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

*these authors contributed equally

Corresponding Author:

  • Marziye Eshghi, PhD
  • Mass General Brigham University of Health Professions
  • 1 Constitution Wharf
  • Charlestown, MA 02129
  • United States
  • Phone: 1 6177241275
  • Email: meshghi@mgh.harvard.edu