Published on in Vol 10 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/86069, first published .
Prediction of Aspiration Risk by Using Vocal Biomarkers: Machine Learning Development and Validation Study

Prediction of Aspiration Risk by Using Vocal Biomarkers: Machine Learning Development and Validation Study

Prediction of Aspiration Risk by Using Vocal Biomarkers: Machine Learning Development and Validation Study

Cyril Varghese   1 , MD, MS ;   Jianwei Zhang   2 , PhD ;   Sara Charney   3 , MS, CCC-SLP ;   Abdelmohaymin A Abdalla   1 , MBBS ;   Elizabeth Reeves   3 , MS, CCC-SLP ;   Stacy Holyfield   3 , MS, CCC-SLP ;   Adam E Brown   4 , BS ;   Michelle K Higgins   4 , MD, PhD ;   Hunter Stearns   4 , BS ;   Julie Liss   5 , PhD, CCC-SLP ;   Nan Zhang   6 , MS ;   Diana Orbelo   7 , PhD, CCC-SLP ;   Rebecca L Pittelko   7 , MS, CCC-SLP ;   Lindsay Rigelman   7 , MA, CCC-SLP ;   Victor Ortega   8 , MD, PhD ;   David G Lott   3 , MD ;   Visar Berisha   2 , PhD

1 Division of Pulmonary and Department of Critical Care Medicine, Mayo Clinic in Arizona, Phoenix, AZ, United States

2 College of Health Solutions, College of Engineering, Arizona State University, Tempe, AZ, United States

3 Division of Laryngology and Department of Otolaryngology- Head & Neck Surgery, Mayo Clinic in Arizona, Phoenix, AZ, United States

4 Mayo Clinic Alix School of Medicine, Mayo Clinic in Arizona, Phoenix, AZ, United States

5 College of Health Solutions, Arizona State University, Tempe, AZ, United States

6 Department of Quantitative Health Sciences, Mayo Clinic in Arizona, Phoenix, AZ, United States

7 Division of Laryngology and Department of Otolaryngology- Head & Neck Surgery, Mayo Clinic, Rochester, MN, United States

8 Division of Pulmonary, Mayo Clinic in Arizona, Phoenix, AZ, United States

Corresponding Author:

  • Cyril Varghese, MD, MS
  • Division of Pulmonary and Department of Critical Care Medicine
  • Mayo Clinic in Arizona
  • 5777 East Mayo Blvd
  • Phoenix, AZ 85054
  • United States
  • Phone: 1 480-301-8244
  • Email: varghese.cyril@mayo.edu