A Machine Learning–Based Scoring System to Identify High Immunoactivity Microsatellite Stability Tumors by Quantifying Similarity to Microsatellite Instability-High Tumors in Colorectal Cancers: Development and Quantitative Study

Hongkai Yan   ^{1, 2, 3 *} , MD ;   Li Jiang   ^{4 *} , Dr rer nat ;   Yaqi Li   ^{1, 3} , MD, PhD ;   Fengchong Wang   ⁵ , MSc ;   Shaobo Mo   ^{1, 3} , MD, PhD ;   Weiqi Sheng   ^{1, 6, 7} , MD, PhD ;   Dan Huang   ^{1, 6, 7 *} , MD, PhD ;   Junjie Peng   ^{1, 3 *} , MD, PhD

¹ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

² Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

³ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

⁴ Weifang Key Laboratory of Collaborative Innovation of Intelligent Diagnosis and Treatment and Molecular Diseases, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, China

⁵ Weifang Ten Nanometer Biotechnology Co., Ltd., Weifang, China

⁶ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

⁷ Institute of Pathology, Fudan University, Shanghai, China

*these authors contributed equally