Published on in Vol 6, No 2 (2022): February

Preprints (earlier versions) of this paper are available at, first published .
A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study

A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study

A Digital Mental Health Intervention in an Orthopedic Setting for Patients With Symptoms of Depression and/or Anxiety: Feasibility Prospective Cohort Study


  1. Iglesias M, Sinha C, Vempati R, Grace S, Roy M, Chapman W, Rinaldi M. Evaluating a Digital Mental Health Intervention (Wysa) for Workers’ Compensation Claimants. Journal of Occupational & Environmental Medicine 2023;65(2):e93 View
  2. Leo A, Schuelke M, Hunt D, Miller J, Areán P, Cheng A. Digital Mental Health Intervention Plus Usual Care Compared With Usual Care Only and Usual Care Plus In-Person Psychological Counseling for Orthopedic Patients With Symptoms of Depression or Anxiety: Cohort Study. JMIR Formative Research 2022;6(5):e36203 View
  3. Sinha C, Cheng A, Kadaba M. Adherence and Engagement With a Cognitive Behavioral Therapy–Based Conversational Agent (Wysa for Chronic Pain) Among Adults With Chronic Pain: Survival Analysis. JMIR Formative Research 2022;6(5):e37302 View
  4. Sinha C, Meheli S, Kadaba M. Understanding Digital Mental Health Needs and Usage With an Artificial Intelligence–Led Mental Health App (Wysa) During the COVID-19 Pandemic: Retrospective Analysis. JMIR Formative Research 2023;7:e41913 View
  5. Gupta M, Malik T, Sinha C. Delivery of a Mental Health Intervention for Chronic Pain Through an Artificial Intelligence–Enabled App (Wysa): Protocol for a Prospective Pilot Study. JMIR Research Protocols 2022;11(3):e36910 View
  6. Alavi N, Moghimi E, Stephenson C, Gutierrez G, Jagayat J, Kumar A, Shao Y, Miller S, Yee C, Stefatos A, Gholamzadehmir M, Abbaspour Z, Shirazi A, Gizzarelli T, Khan F, Patel C, Patel A, Yang M, Omrani M. Comparison of online and in-person cognitive behavioral therapy in individuals diagnosed with major depressive disorder: a non-randomized controlled trial. Frontiers in Psychiatry 2023;14 View
  7. Cheng A, Leo A, Calfee R, Dy C, Armbrecht M, Abraham J. Multi-stakeholder perspectives regarding preferred modalities for mental health intervention delivered in the orthopedic clinic: a qualitative analysis. BMC Psychiatry 2023;23(1) View
  8. Barreveld A, Rosén Klement M, Cheung S, Axelsson U, Basem J, Reddy A, Borrebaeck C, Mehta N. An artificial intelligence-powered, patient-centric digital tool for self-management of chronic pain: a prospective, multicenter clinical trial. Pain Medicine 2023;24(9):1100 View
  9. Inkster B, Kadaba M, Subramanian V. Understanding the impact of an AI-enabled conversational agent mobile app on users’ mental health and wellbeing with a self-reported maternal event: a mixed method real-world data mHealth study. Frontiers in Global Women's Health 2023;4 View
  10. Fundoiano-Hershcovitz Y, Breuer Asher I, Ritholz M, Feniger E, Manejwala O, Goldstein P. Specifying the Efficacy of Digital Therapeutic Tools for Depression and Anxiety: Retrospective, 2-Cohort, Real-World Analysis. Journal of Medical Internet Research 2023;25:e47350 View
  11. Cheng A, Agarwal M, Armbrecht M, Abraham J, Calfee R, Goss C. Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study. JMIR Formative Research 2023;7:e51422 View
  12. Ding H, Simmich J, Vaezipour A, Andrews N, Russell T. Evaluation framework for conversational agents with artificial intelligence in health interventions: a systematic scoping review. Journal of the American Medical Informatics Association 2024;31(3):746 View
  13. Mitsea E, Drigas A, Skianis C. Digitally Assisted Mindfulness in Training Self-Regulation Skills for Sustainable Mental Health: A Systematic Review. Behavioral Sciences 2023;13(12):1008 View
  14. Mazurek J, Cieślik B, Wrzeciono A, Gajda R, Szczepańska-Gieracha J. Immersive Virtual Reality Therapy Is Supportive for Orthopedic Rehabilitation among the Elderly: A Randomized Controlled Trial. Journal of Clinical Medicine 2023;12(24):7681 View
  15. Li H, Zhang R, Lee Y, Kraut R, Mohr D. Systematic review and meta-analysis of AI-based conversational agents for promoting mental health and well-being. npj Digital Medicine 2023;6(1) View
  16. Robinson C, D'Souza R, Yazdi C, Diejomaoh E, Schatman M, Emerick T, Orhurhu V. Reviewing the Potential Role of Artificial Intelligence in Delivering Personalized and Interactive Pain Medicine Education for Chronic Pain Patients. Journal of Pain Research 2024;Volume 17:923 View
  17. Chang C, Sinha C, Roy M, Wong J. AI-Led Mental Health Support (Wysa) for Health Care Workers During COVID-19: Service Evaluation. JMIR Formative Research 2024;8:e51858 View
  18. Chaudhry F, Morgan S, Kruse C, Wolfstadt J, Ekhtiari S. Effect of Depression Interventions in Patients Undergoing Total Joint Arthroplasty Without a Formal Diagnosis of Depression: A Systematic Review. Journal of the American Academy of Orthopaedic Surgeons 2024 View
  19. MacNeill A, Doucet S, Luke A. Effectiveness of a Mental Health Chatbot for People With Chronic Diseases: Randomized Controlled Trial. JMIR Formative Research 2024;8:e50025 View

Books/Policy Documents

  1. Striegl J, Loitsch C, Weber G. Human-Computer Interaction. View
  2. Garcia-Lopez A. The Theory of Mind Under Scrutiny. View
  3. Striegl J, Fekih F, Weber G, Loitsch C. Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management. View