Effectiveness of Secondary Risk–Reducing Strategies in Patients With Unilateral Breast Cancer With Pathogenic Variants of BRCA1 and BRCA2 Subjected to Breast-Conserving Surgery: Evidence-Based Simulation Study

Jelena Maksimenko   ¹ , MD, PhD ;   Pedro Pereira Rodrigues   ² , MSc, PhD ;   Miki Nakazawa-Miklaševiča   ³ , MSc, PhD ;   David Pinto   ⁴ , MD ;   Edvins Miklaševičs   ³ , Prof Dr biol ;   Genadijs Trofimovičs   ⁵ , MD, PhD ;   Jānis Gardovskis   ⁶ , MD, PhD ;   Fatima Cardoso   ⁴ , MD ;   Maria João Cardoso   ⁴ , MD, PhD

¹ Institute of Oncology, Department of Surgery, Breast Unit, Pauls Stradiņš Clinical University Hospital, Riga Stradiņš University, Riga, Latvia

² Information and Health Decision Sciences of the Faculty of Medicine, University of Porto, Porto, Portugal

³ Institute of Oncology, Riga Stradiņš University, Riga, Latvia

⁴ Breast Cancer Unit, Champalimaud Cancer Center, Lisbon, Portugal

⁵ Faculty of Medicine, Rīga Stradiņš University, Riga, Latvia

⁶ Department of Surgery, Faculty of Medicine, Pauls Stradins Clinical University Hospital, Rīga Stradiņš University, Riga, Latvia