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Additionally, the efficacy of the available anti–SARS-Co V-2 NAb therapies varies drastically, and it is difficult to foresee how useful would it be for new circulating variants [3]. Therefore, there is an urgent need for the rapid assessment of anti–SARS-Co V-2 monoclonal antibodies’ potential efficiency to treat emergent variants.
JMIR Bioinform Biotech 2024;5:e58018
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Another challenge is the emergence of SARS-Co V-2 lineages and sublineages (variants) with increased transmissibility [5]. Lineages and sublineages are a series of entities (in this case, genetic) forming a single line of direct ancestry and descent [6]. Emerging SARS-Co V-2 variants have been attributed to the occurrence of secondary, tertiary, quaternary, and quinary COVID-19 epidemic waves and threatening vaccine efforts owing to their immune invasiveness [7].
JMIRx Med 2023;4:e34598
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Participants additionally discussed variant tracking to understand the proportions of certain variants circulating in the community at any given time:
Using phylogenetics to follow the trend of variants of interest and variants of concern to see which proportion of infection at a particular time [is] a particular variant and how variants are competing with each other and taking over.
JMIR Form Res 2023;7:e39409
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Specifically, it remains unclear whether the Omicron variant has an epidemiological advantage over existing variants [8]. Many researchers have proposed that Omicron’s emergence has changed the pandemic’s evolutionary course and speculated its end [10-12].
JMIR Bioinform Biotech 2023;4:e42700
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COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study
Further, few GIS systems track the spatiotemporal transition dynamics of SARS-Co V-2 variants [18].
The impact of using genomic epidemiology to monitor the COVID-19 pandemic has been profound, as it provides unprecedented detail into the appearance and global dissemination of SARS-Co V-2 variants [19-24]. In addition, phylogenetic-epidemiological analysis has enabled the reconstruction of super-spreader events [25].
JMIR Form Res 2022;6(6):e37858
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