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Skip search results from other journals and go to results- 19 JMIR Research Protocols
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Based on other African studies, only an estimated 25% of transgender women are virally suppressed [5-7]. HIV prevalence among transgender women in South Africa mirrors the realities that they share with their peers in other Global South settings, with a 52% mean prevalence documented in 3 South African cities [8].
JMIR Res Protoc 2025;14:e52121
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Transgender, nonbinary, and gender diverse (TGD) young adults in the United States have a two- to four-fold higher risk of major depression [8] and are more likely to screen positive for clinically elevated depressive symptoms relative to their cisgender counterparts [9]. For example, in a national random sample of 65,231 college students drawn from 71 US college campuses, the prevalence of past 2-week depression using PHQ-9 was 57.8% for TGD young adults compared to 28.4% for cisgender young adults [9].
Interact J Med Res 2025;14:e66630
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Transgender and gender-diverse (TGD) people may stop taking gender-related hormonal treatments for reasons unrelated to identity shifts, and it is important to recognize that detransition is distinct from—but sometimes overlaps with—the temporary or permanent discontinuation of gender-related medical care.
J Med Internet Res 2025;27:e63252
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Transgender and gender-diverse (TGD) individuals have poorer mental health outcomes than their cisgender peers, including depression, anxiety, and suicide ideation [1-3]. TGD individuals consistently face significant barriers to accessing gender-affirming medical and surgical treatments, leading many to delay or altogether forgo necessary care [3].
J Med Internet Res 2025;27:e64017
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MSM, transgender women, and genderqueer individuals were eligible if they met the aforementioned criteria.
We partnered with three local agencies for this study. The Magic City Acceptance Academy is the only trauma-informed charter school for LGBTQIA+ (lesbian, gay, bisexual, transgender, intersex, queer/questioning, asexual) individuals in the US Deep South. Magic City Acceptance Academy recruitment was supplemented by recruitment from the Magic City Acceptance Center [32,33].
JMIR Res Protoc 2025;14:e63114
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A record number of anti-LGBTQ (lesbian, gay, bisexual, transgender, queer) bills (more than 400) were introduced across US state legislatures in 2023 [14]. These environmental factors contribute to an alarmingly high rate of suicidality among TGD youth: the 2023 US National Survey on the Mental Health of LGBTQ+ Young People reported that 48% of transgender girls, 56% of transgender boys, and 48% of nonbinary youth had seriously considered attempting suicide in the past year [6].
JMIR Public Health Surveill 2025;11:e66496
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Recently, small studies have demonstrated the ability of patient navigation to connect and engage individuals within diverse LGBTQ+ communities with HIV care [27] and facilitate gender-affirming care for transgender populations [28, 29].
While the significance of care navigation in facilitating access to care within the LGBTQ+ communities has been acknowledged [27-29], research in this area is limited.
JMIR Form Res 2025;9:e64137
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Stigma toward transgender youth contributes to the observed differences in mental health. According to the gender minority stress theory, many of the health disparities observed between transgender and cisgender individuals can be attributed to stressors emerging from the stigma faced by transgender people, also called “transphobia” [6,7].
JMIR Form Res 2025;9:e59605
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Transgender and nonbinary individuals health disparities have been directly linked to intersectional and multidimensional stigma processes [37,41,44,45], underscoring the extent to which this approach is essential for advancements in transgender and nonbinary individual–specific stigma frameworks, measurement, and intervention development.
JMIR Res Protoc 2025;14:e66800
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Within the last 2 decades, as transgender and nonbinary (TGNB) people have gained greater legal and social recognition, those in the TGNB community who want to become pregnant have become increasingly more common, as have the number of families with same-sex, transgender, or nonbinary parents [1].
JMIR Hum Factors 2025;12:e53057
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