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Transgender, nonbinary, and gender diverse (TGD) individuals experience multiple forms of interpersonal and structural stigma and face intersectional gender-, race-, and socioeconomic-based minority stress at various levels [1-4], including within their own families [5-8], resulting in life-threatening health disparities.
JMIR Res Protoc 2025;14:e78619
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Historical erasure of expansive gender identities has contributed to a lack of understanding of HIV likelihood and prevalence within transgender and nonbinary people (those who identify their gender differently from their sex assigned at birth) [2]. The most well-documented incidences are in transgender women, who have a higher rate of HIV acquisition than any other population subgroup.
JMIR Form Res 2025;9:e69255
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Transgender men and transmasculine people—those who identify as men or masculine and were assigned female at birth—have not been centered in HIV prevention efforts until recently [1-3]. Transgender people, who comprise an estimated 1.4 million US adults, are identified as a key population in the 2021-2025 US National Strategic Plan to end the HIV epidemic [4,5].
JMIR Res Protoc 2025;14:e76831
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Example quotes from transgender and gender-diverse content creator videos with corresponding codes.
A total of 42 content creators were included in the analysis. Figure 2 presents a flowchart of the creator selection process.
Transgender and gender-diverse content creator selection process.
Gender identity labels that creators used to describe themselves in more than 1 video were used in analysis.
JMIR Form Res 2025;9:e75787
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Access to specialized transgender health care, however, is limited for TGD people in Germany, especially outside metropolitan areas [7,8].
In order to overcome this issue and to direct TGD people through the decision-making process with respect to transgender health care, there is a need for coordinated and integrated transgender health care.
J Med Internet Res 2025;27:e66371
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“Transgender and gender diverse” (TGD) is an umbrella term for people whose gender identities differ from societal expectations related to the sex they were assigned at birth. Some TGD people may choose to undergo gender-affirming surgery or pursue other forms of gender-affirming care at any point in their lives to alleviate gender dysphoria and better align their physical characteristics with their gender identity.
JMIR Dermatol 2025;8:e62714
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Psychotherapy serves as an effective method for addressing mental health concerns for Two Spirit, transgender, and nonbinary (2 STNB) clients who are people of color.
JMIR Form Res 2025;9:e64477
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#GenderAffirmingHormoneTherapy and Health Information on TikTok: Thematic Content Analysis
Since Tik Tok’s spike in popularity in 2020, transgender and gender diverse (TGD) content creators have used the platform as a space to document and share their experiences with others. While Tik Tok has the potential to disseminate health information and improve access to gender-affirming care, it has come under scrutiny for spreading misinformation, bias, and hate speech [1].
JMIR Infodemiology 2025;5:e66845
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Based on other African studies, only an estimated 25% of transgender women are virally suppressed [5-7]. HIV prevalence among transgender women in South Africa mirrors the realities that they share with their peers in other Global South settings, with a 52% mean prevalence documented in 3 South African cities [8].
JMIR Res Protoc 2025;14:e52121
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Transgender, nonbinary, and gender diverse (TGD) young adults in the United States have a two- to four-fold higher risk of major depression [8] and are more likely to screen positive for clinically elevated depressive symptoms relative to their cisgender counterparts [9]. For example, in a national random sample of 65,231 college students drawn from 71 US college campuses, the prevalence of past 2-week depression using PHQ-9 was 57.8% for TGD young adults compared to 28.4% for cisgender young adults [9].
Interact J Med Res 2025;14:e66630
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