%0 Journal Article
%@ 2561-326X
%I JMIR Publications
%V 9
%N 
%P e64477
%T The Healing Through Ongoing Psychological Empowerment Telehealth Intervention With Two Spirit, Transgender, and Nonbinary Clients of Color in the United States: Open Clinical Trial Feasibility and Implementation Analysis
%A Budge,Stephanie Lynne
%A Tebbe,Elliot Aaron
%A Lee,Joonwoo
%A Domínguez Jr,Sergio
%A Matsuno,Em
%A Lindley,Louis
%K Black, Indigenous, people of color
%K transgender
%K nonbinary
%K radical healing
%K internalized transnegativity
%K open clinical trial
%K psychotherapeutic
%K lack of competence
%K cultural
%K humility
%K psychotherapy
%K therapist
%K HOPE
%K Healing Through Ongoing Psychological Empowerment
%K gender identity
%K intervention
%K content analysis
%K treatment
%K medication
%K mental health
%D 2025
%7 12.5.2025
%9 
%J JMIR Form Res
%G English
%X Background: There is a notable lack of psychotherapeutic services tailored to the needs of Two Spirit, transgender, and nonbinary (2STNB) people of color; research indicates that 2STNB clients who are people of color report a lack of competence and cultural humility on the part of their therapists. Objective: The purpose of this study was to report the feasibility and acceptability of the Healing Through Ongoing Psychological Empowerment (HOPE) teletherapy intervention using deductive content analysis. Methods: We used an open clinical trial design (testing one intervention without a comparison group) to test the feasibility and acceptability of the HOPE intervention. At baseline, 51 clients were enrolled in the open clinical trial, with 49 2STNB clients who are people of color starting and completing the HOPE intervention. Clients were recruited primarily from social media and therapist waitlists. Clients completed up to 15 free face-to-face telehealth psychotherapy sessions that were provided by nine 2STNB therapists who are people of color. Feasibility and acceptability interviews were conducted prior to the intervention, immediately following the intervention, and at 6 months after completing the intervention. Results: The HOPE intervention demonstrated high feasibility and acceptability, specifically regarding data collection, psychometric adequacy, interventionist recruitment or training or retention, delivery of the intervention, acceptability of the intervention to clients, and client engagement with the intervention. Conclusions: These findings propose HOPE as a potentially feasible, culturally specific therapeutic approach for the 2STNB community who are people of color. Future randomized controlled trials comparing HOPE to existing evidence-based treatments are needed. Trial Registration: ClinicalTrials.gov NCT05140174; https://clinicaltrials.gov/study/NCT05140174 
%R 10.2196/64477
%U https://formative.jmir.org/2025/1/e64477
%U https://doi.org/10.2196/64477