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Molecular Detection of SARS-CoV-2 From Throat Swabs Performed With or Without Specimen Collection From the Tonsils: Protocol for a Multicenter Randomized Controlled Trial

Molecular Detection of SARS-CoV-2 From Throat Swabs Performed With or Without Specimen Collection From the Tonsils: Protocol for a Multicenter Randomized Controlled Trial

However, there is considerable variability in the reported diagnostic accuracy of throat swabs, with a 95% CI from 52% to 100% reported in systematic reviews [6,7]. Several studies have found that throat swabs have significantly lower sensitivity than other respiratory specimens [8,9] and the Infectious Diseases Society of America, therefore, does not recommend throat swabs for SARS-Co V-2 testing [10].

Benedikte Hartvigsen, Kathrine Kronberg Jakobsen, Thomas Benfield, Niels Tobias Gredal, Annette Kjær Ersbøll, Mathias Waldemar Grønlund, Henning Bundgaard, Mikkel Porsborg Andersen, Nina Steenhard, Christian von Buchwald, Tobias Todsen

JMIR Res Protoc 2024;13:e47446

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Effectiveness of Self-Collected, Ambient Temperature–Preserved Nasal Swabs Compared to Samples Collected by Trained Staff for Genotyping of Respiratory Viruses by Shotgun RNA Sequencing: Comparative Study

Effectiveness of Self-Collected, Ambient Temperature–Preserved Nasal Swabs Compared to Samples Collected by Trained Staff for Genotyping of Respiratory Viruses by Shotgun RNA Sequencing: Comparative Study

Recent work has demonstrated high percent positive agreement in the detection of SARS-Co V-2 by targeted RT-PCR from self-collected nasal swabs compared to health care provider–collected nasopharyngeal swabs [15-17]. The feasibility of self-collected nasal swabs for detection of pathogen carriage and infection has also been previously demonstrated in an outpatient clinic setting for PCR-based detection of influenza from symptomatic patients [12,14].

Raymond Soto, Litty Paul, Christina A Porucznik, Heng Xie, Rita Czako Stinnett, Benjamin Briggs, Matthew Biggerstaff, Joseph Stanford, Robert Schlaberg

JMIR Form Res 2023;7:e32848

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