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- 9 JMIR Formative Research
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Such an approach promises to increase early treatment retention and thereby improve the quality of care and reduce the risk of overdose death.
All participants received the intervention. Future studies will be trials of AWARE and will include control and intervention groups to test the effect of AWARE.
JMIR Form Res 2025;9:e67401
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Overdose-Related Trends in Online Search Behavior in Japan: Analysis Using Infodemiological Methods
Overdose incidents involving over-the-counter (OTC) and prescription drugs have increased worldwide with the COVID-19 pandemic [1]. In Japan, overmedication of OTC drugs has become a major issue. With digital platforms' essential role in health information access, increase in drug overdose information has raised concerns [2,3]. Although infodemiological research has examined drug-related search behaviors [3], it does not capture the postpandemic increase in overdoses.
J Med Internet Res 2025;27:e73794
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Emergency responders have multiple ways to address overdose, but the primary pharmacological treatment is naloxone [4]. Despite its lifesaving potential, naloxone’s effectiveness is critically hampered by delays in overdose recognition and response [5]. Overdose events often go unrecognized when bystanders are present, and more than half of overdoses occur when someone uses drugs alone and there is no one there to administer naloxone [2,6,7].
J Med Internet Res 2025;27:e73566
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Fatal opioid overdose has a well-defined mechanism—respiratory depression eventually leading to cardiac arrest and death—and decades of research exploring the nature of and antecedents to death. However, this framework and associated research are absent for fatal stimulant poisoning, leading investigators and public health providers to assume stimulant poisoning deaths are similar to opioid overdose deaths and a result of an “overdose.”
JMIR Form Res 2025;9:e64873
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The most significant correlations were observed for the variable “grams opiates” because the official statistics primarily include opiate use and overdose. As a result, the highest correlation between this variable, which can be interpreted as “grams of opiates in the region,” is strongly associated with the rates of deaths from drug overdose (r=.41; P=.003) and the number of HIV-positive people infected by drug use (r=.51; P=.002).
JMIR Form Res 2024;8:e56006
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An increase in overdose deaths globally [1] and in the United States have caused a decrease in average life expectancy [2]. One of the greatest risk factors for a fatal overdose is experiencing a nonfatal overdose involving opioids (NFOO) in the previous year. Indeed, 6% to 10% of individuals who experience an NFOO die in the following year [3-5]. Survivors of NFOOs most commonly die of another overdose (67%) [3], with the highest risk period being the month following NFOO [5].
JMIR Res Protoc 2024;13:e60277
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Worldwide, more than 27 million people have an opioid use disorder and more than 150,000 people die each year from opioid overdose [1,2]. In the United States, in 2022-2023, there are estimated to be more than 100,000 drug overdose deaths [3]. Naloxone is an opioid antagonist and an antidote to opioid overdose.
JMIR Res Protoc 2024;13:e57367
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The United States has set new annual records for overdose deaths almost every year for more than 20 years [1]. Much of this increase is due to a rapidly changing and unpredictable drug supply that can pose myriad health risks [2]. Nationally, more than 107,000 people died from overdose in the 12-month period ending in March 2022 [3], and more people in New York City died from opioid overdose than ever before [4,5].
JMIR Form Res 2024;8:e56755
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Opioids, either obtained illicitly or as a prescription, accounted for approximately 75% of the total drug overdose deaths in 2020 [1,2]. Recent numbers suggest an acceleration of both drug and opioid overdose deaths during the COVID-19 pandemic, with the United States experiencing the largest number of drug overdose deaths during this period (93,300 deaths) compared to that reported in any given year within the last 2 decades.
Online J Public Health Inform 2024;16:e52686
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