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Personalizing a Weight Loss Program Using Cognitive-Behavioral Phenotypes to Improve Engagement and Weight Loss in Adults With Overweight or Obesity: Quasi-Experimental Study

Personalizing a Weight Loss Program Using Cognitive-Behavioral Phenotypes to Improve Engagement and Weight Loss in Adults With Overweight or Obesity: Quasi-Experimental Study

Global obesity rates have doubled since 1990 [1], with approximately 1 in 4 adults in the United Kingdom now living with the condition [2]. Although early interventions focused on telling individuals to “eat less and move more,” research over the past 2 decades has highlighted obesity as a complex, multifactorial issue requiring multicomponent, evidence-based treatment [3]. Many weight loss interventions are generic, offering identical advice to all participants [4,5].

Joanna Szypula, Andreas Jarvstad, Lucy Amelia Jones, Katy Tapper

JMIR Form Res 2025;9:e72645


Evaluating the Impact of Telehealth Exercise Prehabilitation on Cardiometabolic Health in Bariatric Surgery Candidates: Protocol for the BARI-Prehab Randomized Controlled Trial

Evaluating the Impact of Telehealth Exercise Prehabilitation on Cardiometabolic Health in Bariatric Surgery Candidates: Protocol for the BARI-Prehab Randomized Controlled Trial

In 2022, over one billion people were classified as living with obesity, making it a well-recognized and critical global public health concern [1]. A multitude of individual [2], community [3], and countrywide [4,5] weight-management initiatives have been used; yet, the epidemic continues.

Belinda Jayne Durey, Alison M Coates, Kade Davison, Brett Tarca, Jessica Mok, Chetan D Parmar, Naiara Fernandez-Munoz, Katarina Burton, Nicholas Tetlow, Amy Louise Dewar, Mariam Olaide Adeleke, Zoe Lugg, Jack Colbert, Daniel S Martin

JMIR Res Protoc 2025;14:e77538


Effect of Obesity on Perioperative Outcomes Following Lung Cancer Surgery: Protocol for a Meta-Analysis and Systematic Review

Effect of Obesity on Perioperative Outcomes Following Lung Cancer Surgery: Protocol for a Meta-Analysis and Systematic Review

Although obesity is a well-established risk factor for numerous health conditions, its impact on lung cancer surgery outcomes presents a complex and often contradictory picture. The conventional obesity paradox, where a higher BMI is sometimes associated with improved survival in chronic diseases, conflicts with the known physiological challenges obesity imposes on respiratory and cardiac function [4,5]. This creates a significant dilemma for surgeons assessing preoperative risk.

Qiuxiang Wang, Zhishu Li, Xihuan Wang, Bin Li, Chunfeng Wang, Yongguo Xiang

JMIR Res Protoc 2025;14:e76315


Examining the Impact of a Codeveloped Multicomponent Mobile eHealth Lifestyle Intervention on Physical Activity and Its Association With Gestational Weight Gain in Underserved Women: A Statewide Randomized Controlled Trial

Examining the Impact of a Codeveloped Multicomponent Mobile eHealth Lifestyle Intervention on Physical Activity and Its Association With Gestational Weight Gain in Underserved Women: A Statewide Randomized Controlled Trial

Participants were randomized (1:1, parallel arm) by their assigned health coach after the completion of the first outcome visit to either the Healthy Beginnings mobile e Health intervention in addition to WIC services (Intervention Group) or the usual WIC Nutrition only (Usual Care Group), with randomization stratified by BMI (normal weight, overweight, and obesity) and Louisiana Department of Health region.

Hannah E Cabre, Kaja Falkenhain, Abby D Altazan, Emily W Flanagan, Chelsea L Kracht, Joshua R Sparks, Maryam Kebbe, Emily K Woolf, Daniel S Hsia, L. Anne Gilmore, Robbie Beyl, John W Apolzan, Leanne M Redman

J Med Internet Res 2025;27:e73962


Personal Activity Trackers and Family Engagement in a Pediatric Obesity Intervention: Randomized Controlled Trial

Personal Activity Trackers and Family Engagement in a Pediatric Obesity Intervention: Randomized Controlled Trial

Globally, 39 million children younger than 5 years of age, and 340 million between the ages of 5 and 19 years, are overweight or obese, with the prevalence of overweight and obesity reaching approximately 18% worldwide [1]. In the United States, pediatric obesity and associated comorbidities disproportionately impact low-income families and families of color [2,3].

Juan Carlos Espinoza Salomon, Mahsa Babaei, Alexis Deavenport-Saman, Olga Solomon, Choo Phei Wee, Ramon Durazo-Arvizu, Abu Sikder, Payal Shah, Patricia Castillo, Larry Yin

JMIR Form Res 2025;9:e70341


Hybrid Health IT and Telehealth–Delivered Behavioral Weight Loss Services for Primary Care Patients With Cardiovascular Risk Factors: Intervention Component Design and Pragmatic Randomized Feasibility Trial

Hybrid Health IT and Telehealth–Delivered Behavioral Weight Loss Services for Primary Care Patients With Cardiovascular Risk Factors: Intervention Component Design and Pragmatic Randomized Feasibility Trial

Reference 1: Behavioral and pharmacotherapy weight loss interventions to prevent obesity-related morbidity Reference 7: The state of obesity: better policies for a healthier America(https://www.tfah.org/wp-content Reference 14: Effectiveness of an app and provider counseling for obesity treatment in primary care Reference 15: Track: a randomized controlled trial of a digital health obesity treatment intervention Reference 16: An internet-based intervention with brief nurse support to manage obesity in primary careobesityObesity and Nutrition as Public Health Problem

Ronald T Ackermann, Kenzie A Cameron, David T Liss, Nancy Dolan, Cassandra Aikman, Amy R Carson, Sterling A Harris, Kathryn Doyle, Andrew J Cooper, Brian Hitsman

JMIR Mhealth Uhealth 2025;13:e58722


Effectiveness of a Digital Therapy on 6-Month Weight Loss in People With Obesity: The Digital Therapy to Promote Weight Loss in Patients With Obesity by Increasing Their Adherence to Treatment (DEMETRA) Randomized Clinical Trial

Effectiveness of a Digital Therapy on 6-Month Weight Loss in People With Obesity: The Digital Therapy to Promote Weight Loss in Patients With Obesity by Increasing Their Adherence to Treatment (DEMETRA) Randomized Clinical Trial

Furthermore, obesity has profound consequences for patients’ quality of life, leading to social and psychological impairments as well as functional limitations [3]. It is considered a global pandemic, currently affecting approximately 1 billion people worldwide, including both adults and children [4]. The treatment of people living with obesity continues to present significant challenges for health care professionals.

Simona Bertoli, Paolo Capodaglio, Santo Colosimo, Ramona Silvana De Amicis, Luisa Gilardini, Amalia Bruno, Sara Paola Mambrini, Giada Pietrabissa, Luca Cavaggioni, Gianluca Castelnuovo, Giuseppina Piazzolla

J Med Internet Res 2025;27:e72054


A Remotely Delivered Weight Management Service to Support Existing Obesity Services in the UK National Health Service: Preliminary Findings From an Early-Stage Service Evaluation

A Remotely Delivered Weight Management Service to Support Existing Obesity Services in the UK National Health Service: Preliminary Findings From an Early-Stage Service Evaluation

Around 1 in 3 adults in the United Kingdom are affected by obesity [1-4] (defined as abnormal or excessive fat accumulation that presents a risk to health, with a BMI of ≥30 [1]). Many people living with obesity are also burdened by weight-related conditions such as cardiovascular disease, type 2 diabetes, liver disease, and sleep apnea and are at risk of many cancers [1,5]. In addition to poorer physical health, obesity is associated with poorer mental health [6-8] and lower quality of life [9].

Giulia Spaltro, Michael Whitman, Rebecca Richards

JMIR Form Res 2025;9:e71914


Exploring the Use of Digital Technology to Support Health Behavior Change in Young People Under the Care of Complications of Excess Weight (CCEW) Clinics: Qualitative Patient-Centered Design Study

Exploring the Use of Digital Technology to Support Health Behavior Change in Young People Under the Care of Complications of Excess Weight (CCEW) Clinics: Qualitative Patient-Centered Design Study

The growing prevalence of childhood obesity is among the most important threats to public health globally [1]. In addition to being at a higher risk of significant childhood comorbidities [2], children living with overweight and obesity are more likely to experience obesity in adulthood [3]. Adults living with obesity are at markedly increased risk of a wide range of noncommunicable diseases, including cardiovascular diseases, diabetes, musculoskeletal disorders, and certain types of cancer [4].

Brioney Gee, Bonnie Teague, Matt Farrar, Victoria Farrar, Dorothy Szinay, Li F Chan, Ken K Ong, Ben Jackson, Sydney Wylie, Felix Naughton, Jon Wilson, Emma Alice Webb

JMIR Form Res 2025;9:e64947


Impact of a 24-Week Mobile App–Based Human Coaching Program on Body Composition and Lipid Metabolism in Breast Cancer Survivors With Overweight or Obesity: Single-Arm Prospective Cohort Study

Impact of a 24-Week Mobile App–Based Human Coaching Program on Body Composition and Lipid Metabolism in Breast Cancer Survivors With Overweight or Obesity: Single-Arm Prospective Cohort Study

Obesity is associated with the risk of breast cancer and its recurrence. This relationship involves altered fatty acid metabolism, extracellular matrix remodeling, secretion of adipokines and anabolic and sex hormones, immune dysregulation, and chronic inflammation [1]. A previous systematic meta-analysis showed that women with obesity and breast cancer had poorer survival rates than women without obesity [2].

Eun-Gyeong Lee, Dong-Eun Lee, Jeongseon Kim, Jaihong Han, Seeyoun Lee, Han-Sung Kang, Eun Sook Lee, Heejung Chae, Sung Hoon Sim, Keun Seok Lee, Jungeun Lee, Hyun Jeong Lee, Ji Sung Yoo, Gyung Ah Wie, So-Youn Jung

JMIR Mhealth Uhealth 2025;13:e64846