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Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Seborrheic dermatitis is a chronic inflammatory skin disease that commonly presents on the face, scalp, and chest [1]. Seborrheic dermatitis affects approximately 5% of the global population, while its noninflammatory form affects closer to 50% of individuals [2]. Seborrheic dermatitis prefers males of all ethnicities and peaks in the first 3 months of life and again at puberty, where it then reaches an apex at 40-60 years and later declines [3,4].

Emily Woolhiser, Noah Keime, Arya Patel, Isaac Weber, Madeline Adelman, Robert P Dellavalle

JMIR Dermatol 2024;7:e50143

From the Cochrane Library: Leukotriene Receptor Antagonists for Eczema

From the Cochrane Library: Leukotriene Receptor Antagonists for Eczema

Atopic dermatitis (AD), a chronic inflammatory skin disease, is estimated to affect up to 10% of adults and 20% of children worldwide [1]. Clinical manifestations include pruritus, skin lesions, and dry scaly skin [2,3]. First-line treatment includes topical steroids and emollients, with systemic steroids or immune modulators for moderate-to-severe AD.

Lauren Marie Toledo, Ramiro Rodriguez, Torunn E Sivesind, Efstratios Vakirlis, Reiji Kojima, Robert P Dellavalle

JMIR Dermatol 2024;7:e50434

Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial

Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial

Seborrheic dermatitis (SD) is related to increased sebum production and an inflammatory response to cutaneous Malassezia, and it affects 18.6%-59% of persons with Parkinson disease (PD) [1,2]. The mechanism connecting these two pathologies is not entirely clear; however, increasing evidence suggests a direct role of Malassezia in the pathogenesis of PD [2].

Isaac Weber, Caterina Zagona-Prizio, Torunn E Sivesind, Madeline Adelman, Mindy D Szeto, Ying Liu, Stefan H Sillau, Jacquelyn Bainbridge, Jost Klawitter, Cristina Sempio, Cory A Dunnick, Maureen A Leehey, Robert P Dellavalle

JMIR Dermatol 2024;7:e49965

The Impact of Intervention Design on User Engagement in Digital Therapeutics Research: Factorial Experiment With a Mixed Methods Study

The Impact of Intervention Design on User Engagement in Digital Therapeutics Research: Factorial Experiment With a Mixed Methods Study

We used “Atomind,” a DTx for patients with atopic dermatitis (AD), developed for clinical trial purposes, with a primary focus on optimization as a refinement process before validating its effectiveness through larger RCTs. This was a proof-of-concept study with an experimental 2 × 2 factorial design, using both quantitative (eg, in-app behavioral data) and qualitative (eg, semistructured interviews) assessment methods.

Hyerim Lee, Eung Ho Choi, Jung U Shin, Tae-Gyun Kim, Jooyoung Oh, Bokyoung Shin, Jung Yeon Sim, Jaeyong Shin, Meelim Kim

JMIR Form Res 2024;8:e51225

Patient Phenotyping for Atopic Dermatitis With Transformers and Machine Learning: Algorithm Development and Validation Study

Patient Phenotyping for Atopic Dermatitis With Transformers and Machine Learning: Algorithm Development and Validation Study

Accuracy of different multilayer perceptron networks in discerning sentences by atopic dermatitis (AD) indicator categories using “Bio Clinical Bidirectional Encoder Representations from Transformers” sentence embeddings. Accuracy of different multilayer perceptron networks in discerning sentences by atopic dermatitis (AD) indicator categories using “Bidirectional Encoder Representations from Transformers Base Uncased” sentence embeddings.

Andrew Wang, Rachel Fulton, Sy Hwang, David J Margolis, Danielle Mowery

JMIR Form Res 2024;8:e52200

A Mobile Health App for Facilitating Disease Management in Children With Atopic Dermatitis: Feasibility and Impact Study

A Mobile Health App for Facilitating Disease Management in Children With Atopic Dermatitis: Feasibility and Impact Study

Atopic dermatitis (AD) ranks highest among all skin disorders as a cause of lost disability-adjusted life-years in patients worldwide [1]. Poor medication adherence is a major barrier to treatment success in AD and results from various underlying causes, including forgetfulness, medication side effects, complex dosing regimens, cost barriers, a lack of understanding about the importance of the medication, and disruptions to daily activities [2,3].

Alex Zvulunov, Stepan Lenevich, Natalia Migacheva

JMIR Dermatol 2023;6:e49278

Safety Evaluation in Iterative Development of Wearable Patches for Aripiprazole Tablets With Sensor: Pooled Analysis of Clinical Trials

Safety Evaluation in Iterative Development of Wearable Patches for Aripiprazole Tablets With Sensor: Pooled Analysis of Clinical Trials

In some studies, participants were excluded if unable to use wearable patches due to known allergies to adhesives or dermatological issues such as active skin infection, active dermatitis, or chronic inflammatory skin conditions (eg, psoriasis). The duration of the clinical trials ranged from 1 day to 6 months. Six short-term studies were less than 2 weeks, and 6 long-term studies were at least 4 weeks; there were no studies with a length between 2 and 4 weeks (Multimedia Appendix 1).

Michael Jan, Antonia Coppin-Renz, Robin West, Christophe Le Gallo, Jeffrey M Cochran, Emiel van Heumen, Michael Fahmy, J Corey Reuteman-Fowler

JMIR Form Res 2023;7:e44768

Assessing the Accuracy and Comprehensiveness of ChatGPT in Offering Clinical Guidance for Atopic Dermatitis and Acne Vulgaris

Assessing the Accuracy and Comprehensiveness of ChatGPT in Offering Clinical Guidance for Atopic Dermatitis and Acne Vulgaris

This study characterizes the accuracy and comprehensiveness of Chat GPT in responding to common patient questions for acne vulgaris and atopic dermatitis (AD). For each condition (acne vulgaris and AD), 32 potential patient questions were created based on American Academy of Dermatology (AAD) guidelines and web-based resource centers [4,5].

Nehal Lakdawala, Leelakrishna Channa, Christian Gronbeck, Nikita Lakdawala, Gillian Weston, Brett Sloan, Hao Feng

JMIR Dermatol 2023;6:e50409

Skin of Color Representation for Atopic Dermatitis on TikTok: Cross-Sectional Analysis

Skin of Color Representation for Atopic Dermatitis on TikTok: Cross-Sectional Analysis

Atopic dermatitis affects millions of people worldwide, with potentially substantial impacts. With the popular social media platform Tik Tok, dermatologists can share skin health information with a larger audience. Since launching in 2016, Tik Tok has had over 1 billion monthly active users and is the world’s fastest-growing social media platform [1].

Alyssa Abdelnour, Nicholas Comeau, Kurt Ashack

JMIR Dermatol 2023;6:e48635