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Gender minority populations, including transgender, nonbinary, and gender-diverse individuals, experience increased risk of depression relative to cisgender counterparts due to chronic exposure to structural and interpersonal stressors [1,2]. As the leading cause of disability worldwide [3], depression is a serious public health concern.
JMIR Form Res 2025;9:e75290
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Young people living with HIV also bear a disproportionate burden of depression compared to the general population, which is a key driver of poor HIV outcomes such as higher rates of interruptions in care, medication nonadherence, virologic failure, and progression of HIV [4-7].
Cognitive behavioral therapy (CBT)–based interventions are highly effective in treating depression and have been successfully used across the age spectrum from adolescents to older people [8-10].
JMIR Res Protoc 2025;14:e74199
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During onboarding, 98% of all patients are screened for depression and anxiety using the Patient Health Questionnaire-9 (PHQ-9) [27] and General Anxiety Disorder-7 (GAD-7) [28], and 48% and 45% of patients meet the clinical cutoff of ≥10 on these measures, respectively. Of those with a positive screen on either measure, 84% start care within 30 days.
JMIR Form Res 2025;9:e76264
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Early childhood is a critical period for brain development, and maternal depression can have a detrimental effect during this time. A few studies show that women are particularly susceptible to depression during the antenatal and postnatal periods. Depression can be due to hormonal changes and various psychosocial factors [1]. As a result, depression is more frequently reported in pregnant women than in those who are not pregnant [2].
JMIR Res Protoc 2025;14:e63663
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h NS: not significant.
i ES: effect size.
j FU: follow-up.
k WAQ: Working Alliance Questionnaire.
l CESD-R: Center for Epidemiologic Studies Depression Scale–Revised.
m PSWQ: Penn State Worry Questionnaire.
n STAI: State–Trait Anxiety Inventory.
o PSS-10: Perceived Stress Scale.
p EPDS: Edinburgh Postnatal Depression Scale.
q CBT-I: cognitive behavioral therapy for insomnia.
r ISI: Insomnia Severity Index.
s ESS: Epworth Sleepiness Scale.
t DBAS: Dysfunctional Beliefs and Attitudes About Sleep Scale.
JMIR Ment Health 2025;12:e78340
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To this date (July 5, 2024), 4 Di GA (ie, deprexis, edupression.com, Novego, and Selfapy) are permanently listed for use in depressive disorders, and another 3 Di GA are temporarily approved for 1 year (elona therapy Depression, Mind Doc auf Rezept, and My7steps App) [11].
The first 2 permanently approved Di GA for treating depressive disorders were deprexis and Selfapy [11].
JMIR Hum Factors 2025;12:e66271
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Longitudinal research documents bidirectional relationships between cognitive function and depression in later life, with cognitive decline predicting increased depression risk and depressive symptoms accelerating cognitive deterioration [25]. If digital engagement is associated with enhanced cognitive function through stimulation and learning, as suggested by cognitive reserve research [16], this might create indirect protective effects against depression.
JMIR Aging 2025;8:e80700
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Depression is a severe illness that affects around 280 million people globally [1]. The COVID-19 pandemic worsened the situation, with an estimated 27.6% increase in cases of major depressive disorder [2]. Individuals with depression symptoms may avoid seeking medical help due to cost, time, possible side effects of medication, and social stigma [3]. The resulting unmet need for depression support has increased the demand for alternative services.
JMIR Form Res 2025;9:e71538
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Beyond difficulties among the general population [11,12], the maintenance of health-related behavior change can be even more challenging in people with subclinical and clinical mental health symptoms, wherein motivational deficits and anhedonia reflect cardinal symptoms of various psychiatric conditions, such as major depression, schizophrenia spectrum disorders, eating disorders, and posttraumatic stress disorder [13].
JMIR Form Res 2025;9:e77036
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The most significant mental health concerns facing urban Indigenous communities include a high prevalence of substance use disorders [5], depression, suicide, anxiety [6], and posttraumatic stress disorder (PTSD) [2]. For example, estimates of rates of PTSD among Indigenous people range from 16% to 24% [7-9], which is 3 times the rate of lifetime PTSD among the general population [10], and rivals the lifetime rate (29%) among US veterans returning from Iraq and Afghanistan [11].
JMIR Res Protoc 2025;14:e67757
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