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Guided Inhalation via Electronic Monitoring in Children With Uncontrolled Asthma (the IMAGINE Study): Randomized Controlled Trial

Guided Inhalation via Electronic Monitoring in Children With Uncontrolled Asthma (the IMAGINE Study): Randomized Controlled Trial

The initial management of asthma is guided by the activity of the disease [3,4], requiring ongoing monitoring of asthma control to determine whether current therapies should be maintained or adjusted [3,5,6]. Accordingly, international guidelines [3,7] recommend that physicians reassess therapy adherence, the quality of inhalation technique, environmental factors, and associated comorbidities before considering escalation of pediatric asthma therapy [5,6,8,9].

Esther Sportel, Kris Movig, Bernard Thio, Mattienne Van der Kamp, Job Van der Palen, Marjolein Brusse-Keizer

JMIR Pediatr Parent 2025;8:e78526


The Clinical Registry of Childhood Asthma (CRCA) Elucidating Early-Life Asthma: Cross-Sectional Analysis of a Prospective, Longitudinal, and Digitally Enhanced Real-World Cohort

The Clinical Registry of Childhood Asthma (CRCA) Elucidating Early-Life Asthma: Cross-Sectional Analysis of a Prospective, Longitudinal, and Digitally Enhanced Real-World Cohort

To address these issues, the Global Initiative for Asthma (GINA) 2025 report has introduced, for the first time, diagnostic criteria and a definition for suspected asthma in children under 6 years old [3]. Despite this important step, the characteristics of early-life asthma in outpatient settings remain poorly characterized. This gap is particularly critical since the first 5 years of life constitute a key window for allergen sensitization [7], the foremost risk factor for childhood asthma.

Juan Li, Luo Ren, Jiao Liu, Yuyi Tang, Run Wang, Peixin Yang, Jing Zhao, Xiao Chen, Zheng Xiang, Wen Zhong, Na Zang, Dapeng Chen, Heping Fang, Enmei Liu

J Med Internet Res 2025;27:e78693


Effects of Aerobic Training Versus Behavioral Intervention to Increase Physical Activity for Disease Control in Patients With Asthma: Protocol for a Randomized Trial

Effects of Aerobic Training Versus Behavioral Intervention to Increase Physical Activity for Disease Control in Patients With Asthma: Protocol for a Randomized Trial

People with asthma are less physically active than their healthy counterparts [11]; thus, developing strategies to modify behavior, increase physical activity, and reduce sedentary time among people with asthma is important [12]. Freitas et al [8] applied an 8-week BI to increase PADL and reported improvements in clinical asthma control, PADL, sleep quality, and anxiety symptoms in adults with moderate to severe asthma. Another effective strategy to improve the clinical control of asthma is the AT [13,14].

David Halen Araujo Pinheiro, Ronaldo Aparecido da Silva, Adriana Claudia Lunardi, Vitoria Zacarias Cervera, Regina Maria Carvalho-Pinto, Fabiano Francisco de Lima, Celso R F Carvalho

JMIR Res Protoc 2025;14:e78603


An mHealth App and System Architecture for Respiratory Disease Management: Design Principles, Tool Development, and Pilot Usability Study

An mHealth App and System Architecture for Respiratory Disease Management: Design Principles, Tool Development, and Pilot Usability Study

However, Cochrane systematic reviews report mixed benefits for m Health interventions targeting patients with asthma and COPD specifically. Belisario et al [24] evaluated smartphone and tablet apps versus paper-based asthma action plans in 2 randomized controlled trials (n=408 participants) over 6 months. While emergency visits decreased significantly, symptom control showed no improvement on the patient-reported Asthma Control Questionnaire (ACQ). Likewise, mixed results are also noted in COPD research.

Andrew Chao, Lisa Martignetti, René Groh, Andreas M Kist, Nicole YK Li-Jessen

JMIR Form Res 2025;9:e73584


Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database

Comparative Analysis of Outcomes of Influenza and COVID-19 Admissions Among Children With Asthma: A Nationwide Retrospective Cohort Study Using the US National Readmissions Database

Asthma prevalence has risen steadily worldwide over the past 4 decades [1]. The incidence of childhood asthma has markedly increased over the past 40 years. Despite therapeutic advances, underdiagnosis and undertreatment remain common in children with asthma [2,3]. Respiratory viral infections such as COVID-19 and influenza often precipitate severe asthma exacerbations in children. Recent research indicates that asthma increases the risk of hospitalization in children with COVID-19 [4,5].

Ying-Chen Chen, Chia-Pi Cheng, Po-Cheng Chen, Jinn-Li Wang, Chia-Chen Wu, Ying-Chun Lu

JMIR Med Inform 2025;13:e73047


Selection of Behavior Change Techniques for Asthma Medication Adherence Apps: Evidence-Based Design Study

Selection of Behavior Change Techniques for Asthma Medication Adherence Apps: Evidence-Based Design Study

For the present piece of work, the Centre for Business Innovation collaborated with Asthma UK (now Asthma+ Lung UK) to map out the behavioral factors influencing adherence to preventer medication for adults with asthma and apply a rigorous approach to identify the BCTs most relevant to promoting medication adherence for people with asthma. Asthma is a common long-term condition, affecting an estimated 260 million people worldwide in 2019 [11].

Alison J Wright, Jeremy Holland, Iain Simpson, Samantha Walker, Naomi Bennett-Steele, John Weinman

JMIR Mhealth Uhealth 2025;13:e49348


Using mHealth to Predict Asthma Exacerbations in Children and Adolescents (Mobile Health for Kids With Asthma): Protocol for an Observational Study

Using mHealth to Predict Asthma Exacerbations in Children and Adolescents (Mobile Health for Kids With Asthma): Protocol for an Observational Study

Severe exacerbations are common, with approximately 10% of Canadian children with asthma having had 1 or more asthma-related ED visits in the previous 2 years [10,11]. Asthma morbidity and mortality are higher in children and adolescents compared with adults [12], and morbidity is particularly high in preschool-aged children [13,14] who represent >50% of all asthma-related ED visits [10]. There are several known risk factors for severe asthma exacerbations.

Naphtal Nyirimanzi, Myriam Bransi, François-Pierre Counil, Olivier Drouin, Jocelyn Gravel, Anne Hicks, Cristina Longo, Theo J Moraes, Esli Osmanlliu, Dhenuka Radhakrishnan, Connie Yang, Teresa To, Bruce Wright, Sze Man Tse

JMIR Res Protoc 2025;14:e70517


Technical Description of eHealth Tools in an Environmental Exposure Chamber: Implementation Study

Technical Description of eHealth Tools in an Environmental Exposure Chamber: Implementation Study

Rhinoconjunctivitis and asthma in patients who are polysensitized to different aeroallergens constitute a challenge for their diagnosis and treatment, since there is a need to identify the relationship between the load of a specific allergen and patients’ symptoms, considering that, in some cases, pollination takes place at the same time of the year for different species.

Irene Garcia-Gutierrez, Irene Dueñas-Requena, Violeta Sanchez-Garcia, Cristiana Solorzano-Zepeda, Samuel Santos-Benito, Belen de la Hoz-Caballer, Dario Antolin-Amerigo

JMIR Form Res 2025;9:e71276


Exploring Young Adults' Experiences and Beliefs in Asthma Medication Management: Pilot Qualitative Study Comparing Human and Multiple AI Thematic Analysis

Exploring Young Adults' Experiences and Beliefs in Asthma Medication Management: Pilot Qualitative Study Comparing Human and Multiple AI Thematic Analysis

Asthma, a chronic respiratory disease, imposes a significant burden on individuals of all ages. In the United States alone, approximately 25 million people have a diagnosis of asthma, leading to missed school or work days, emergency department visits, and premature death [1,2]. According to data published by the Centers for Disease Control and Prevention, there were over 1.8 million asthma-related emergency department visits in 2019 [1].

Ruth Ndarake Jeminiwa, Caroline Popielaski, Amber King

JMIR Form Res 2025;9:e69892


Real-World Comparison of Telemonitoring Versus Conventional Care in Patients With Chronic Obstructive Pulmonary Disease and Those With Asthma—Impact on Clinical Outcomes and Patient Characteristics: Retrospective Cohort Study

Real-World Comparison of Telemonitoring Versus Conventional Care in Patients With Chronic Obstructive Pulmonary Disease and Those With Asthma—Impact on Clinical Outcomes and Patient Characteristics: Retrospective Cohort Study

Chronic obstructive pulmonary disease (COPD) and asthma belong to the most common chronic diseases and their incidence continues to rise [1]. The World Health Organization states that COPD is the third leading cause of death globally, resulting in 3.23 million deaths in 2019 [2]. Asthma is a prevalent disease, causing more than 455,000 deaths in 2019 [3]. Both COPD and asthma are diseases that progress variably.

Lidy Aaltje Catharina Roubos, Heleen Westland, Niesje Lieset Hulstein-Brink, Rosalie Constance Visser, Jan Willem K van den Berg, Jobbe PL Leenen

J Med Internet Res 2025;27:e66743