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Digital Infrared Thermographic Imaging for Limb Salvage in Patients at Risk of Amputation: Prospective Observational Study

Digital Infrared Thermographic Imaging for Limb Salvage in Patients at Risk of Amputation: Prospective Observational Study

ΔT values of patients at risk of limb amputation, stratified by thermal asymmetry pattern: (A) ΔT-positive group and (B) ΔT-negative group. Each plot shows ΔT values across three time points (Day 1, Day 5, and Day 84). Asterisks indicate levels of statistical significance (*P < .05, **P < .01, ***P < .001). 20 patients presented with a negative ΔT, with limb salvage achieved in 18 cases and amputation required in 2.

Víctor Manuel Loza-González, Eleazar Samuel Kolosovas-Machuca, Patricia Aurea Cervantes-Báez, José Luis Ramírez-GarcíaLuna, Edgar Guevara, Mario Aurelio Martínez-Jiménez

JMIR Form Res 2025;9:e69072

Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

Associations Between Daily Symptoms and Pain Flares in Rheumatoid Arthritis: Case-Crossover mHealth Study

(B) Two scenarios of exclusion. Left: the onset (day 4) meets the definition, but the pain severity is at the personal median pain level, conflicting with the criterion for the end of a pain flare. Right: 2 flare onsets (days 2 and 4) meet the definition but end on the same day (day 5). The second onset (day 4) is removed to avoid double counting. In addition to identifying pain flares by their severity, we examined their residual impact in the postflare phase.

Ting-Chen Chloe Hsu, Belay B Yimer, Pauline Whelan, Christopher J Armitage, Katie Druce, John McBeth

JMIR Mhealth Uhealth 2025;13:e64889

Authors’ Response to Peer Review of “Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study”

Authors’ Response to Peer Review of “Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study”

“Sixteen participants (N=16) between ages 26-31 took part in the study, and demographic information, including race and gender, was collected and is summarized in Table 2a-b. Each trial lasted about 10-15 minutes and was divided into three phases: baseline, CPT (Cold Pressor Test), and recovery. The length of the trial and the data used for feature analysis is as detailed in Table 2c-d.” The captions of the figures should have statistical information when relevant.

Jadelynn Dao, Ruixiao Liu, Sarah Solomon, Samuel Aaron Solomon

JMIRx Med 2025;6:e77440

Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study

Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study

B. Blink examples (blue) plotted against wire examples (green), as filtered EOG voltage signals, normalized per peak between 0 and 1. Peaks are time-aligned by time, in seconds, from the center of peak. Wire signals typically have higher variability. C. A singular blink peak. The purple dot marks the peak of the blink event, while the outer edges of the red and grey shaded sections represent the boundaries used for feature extraction.

Jadelynn Dao, Ruixiao Liu, Sarah Solomon, Samuel Aaron Solomon

JMIRx Med 2025;6:e69472