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Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Previously experienced hypersensitivity after taking HH333’s constituent medicines Scutellariae radix, Coptidis rhizoma, Phellodendri cortex, Gardeniae fructus, and Rhei rhizoma. Any other study medications administered within 30 days prior to screening. Patients who have not been administered the study medication or who have participated in a simple observational clinical trial are eligible. Difficulty taking the doses required in this study.

Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Cheol-Hyun Kim, Dong-Jun Choi

JMIR Res Protoc 2025;14:e70953