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Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

It was conducted at 3 university Korean medicine hospitals in South Korea: Kyung Hee University Korean Medicine Hospital, Dongguk University Ilsan Korean Medicine Hospital, Wonkwang University Gwangju Korean Medicine Hospital. Within 90 days of onset at baseline, patients will receive HH333 or a placebo, 2 capsules (800 mg) at a time, once a day for 720 days.

Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Cheol-Hyun Kim, Dong-Jun Choi

JMIR Res Protoc 2025;14:e70953