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Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

A total of 6 (29%) of the 14 external validations assessed discrimination, with all using the c-statistic. Birks et al [21] externally validated Colon Flag at multiple time intervals between the most recent blood test and diagnosis in a UK sample, reporting c-statistic=0.844 at 3‐6 months, which reduced to 0.751 at 23‐36 months [21]. Kinar et al [27] also externally validated the Colon Flag using UK data and reported a similar c-statistic (0.81) at 3‐6 months before colorectal cancer diagnosis [27].

Pradeep S Virdee, Kiana K Collins, Claire Friedemann Smith, Xin Yang, Sufen Zhu, Nia Roberts, Jason L Oke, Clare Bankhead, Rafael Perera, FD Richard Hobbs, Brian D Nicholson

JMIR Cancer 2025;11:e70275

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

To describe the epidemiology and management of pediatric appendicitis, illustrating: (A) The burden of disease in patients presenting with acute abdominal pain with the suspicion of appendicitis; (B) The incidence and type of surgical procedures undertaken in the management of appendicitis in ANZ (laparoscopic appendectomy, open appendectomy, nonsurgical management with intravenous antibiotics, and delayed appendectomy); (C) The imaging procedures undertaken in patients assessed for possible appendicitis, and

Wei Hao Lee, Sharon O'Brien, Elizabeth J Mckinnon, Simon Craig, Stuart Dalziel, Michael Collin, Natalie Phillips, Franz E Babl, Sarah Julia Davidson, Shane George, Shefali Jani, Doris Tham, Viet Tran, Meredith L Borland

JMIR Res Protoc 2025;14:e67941