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Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

The maximum acceptable inferiority for experimental versus control on the primary outcome is therefore expected to be a standardized difference (Cohen d=0.39), which corresponds to a label between small or medium, depending on the guidelines (R effect size package) [44]. Considering a one-sided significance level of 2.5% and a power of 90%, it is necessary to include 137 participants per group (G*Power 3.1).

Charline Grossard, Mélanie Descamps, Sara Cadoni, Hugues Pellerin, François Vonthron, Jean Xavier, Bruno Falissard, David Cohen

JMIR Res Protoc 2025;14:e71326

Testing and Iterative Improvement of the CEN ISO/TS 82304-2 Health App Quality Assessment: Pilot Interrater Reliability Study

Testing and Iterative Improvement of the CEN ISO/TS 82304-2 Health App Quality Assessment: Pilot Interrater Reliability Study

The Gwet AC1 was used as it has been shown to provide stable interrater reliability coefficients without being substantially affected by response prevalence or marginal probability (as is, eg, the case for the Cohen κ). In addition, it is suitable for designs that are not fully crossed over, such as the one used in this study, in which different pairs of raters evaluated the varying apps [33]. Gwet AC1 values can be interpreted as follows using Altman benchmark ranges [33]: 0.60="good agreement."

Anna-Lena Frey, Diana Matei, Ben Phillips, Adam McCabe, Rachel Fuller, Begoña Laibarra, Laura Alonso, Victor de la Hoz, Carme Pratdepadua Bufill, Berta Llebot Casajuana, Giuseppe D'Avenio, Pier Angelo Sottile, Laura Melania Rocchi, Matteo Errera, Yasmine Laaissaoui, Michael Cardinal, Menno Kok, Petra Hoogendoorn

JMIR Form Res 2025;9:e64565

GPT-4 as a Clinical Decision Support Tool in Ischemic Stroke Management: Evaluation Study

GPT-4 as a Clinical Decision Support Tool in Ischemic Stroke Management: Evaluation Study

Agreement between treatment decisions was measured using a linear weighted Cohen κ coefficient, using the psych 2.3.12 library. This study was approved by the Rambam Medical Center Helsinki Committee (0156-24-D) as a retrospective analysis. The requirement for informed consent was waived due to the retrospective nature of the study and the use of deidentified data. All patient information was anonymized prior to analysis, with all identifiers, names, and dates removed to ensure privacy and confidentiality.

Amit Haim Shmilovitch, Mark Katson, Michal Cohen-Shelly, Shlomi Peretz, Dvir Aran, Shahar Shelly

JMIR AI 2025;4:e60391