Accepted for/Published in: Journal of Medical Internet Research

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  • Xiaopeng W, Jiaxin Z, Chang L, Haowen Z, Guanduo S, Jingming Z, Haijun Y, Haijun Y
  • Deciphering Lactate Metabolism in Colorectal Cancer: Prognostic Modeling, Immune Infiltration, and Gene Mutation Insights
  • Journal of Medical Internet Research
  • DOI: 10.2196/11848
  • PMID: 30303485
  • PMCID: 6352016
Preprints Accepted Manuscript

Deciphering Lactate Metabolism in Colorectal Cancer: Prognostic Modeling, Immune Infiltration, and Gene Mutation Insights

Abstract

This study offers an in-depth analysis of the role of lactate metabolism in colorectal cancer (CRC), highlighting its significance in the tumor microenvironment (TME) and therapeutic response. Utilizing single-cell and transcriptomic data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA), we identified key lactate metabolic activities, particularly in the monocyte/macrophage subpopulation. Seven lactate metabolism-associated genes were significantly linked to CRC prognosis and used to construct a predictive model. This model accurately forecasts patient outcomes and reveals notable differences in immune infiltration and gene mutation profiles between high- and low-risk groups. High-risk patients demonstrated elevated immune cell infiltration, increased mutation frequencies, and heightened sensitivity to specific drugs (AZD6482, tozasertib, and SB216763), providing a foundation for personalized treatment approaches. Additionally, a nomogram integrating clinical and metabolic data effectively predicted 1-, 3-, and 5-year survival rates. These findings underscore the pivotal role of lactate metabolism in CRC prognosis and suggest novel avenues for therapeutic intervention.

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© The authors. All rights reserved. This is a privileged document currently under peer-review/community review (or an accepted/rejected manuscript). Authors have provided JMIR Publications with an exclusive license to publish this preprint on it’s website for review and ahead-of-print citation purposes only. While the final peer-reviewed paper may be licensed under a cc-by license on publication, at this stage authors and publisher expressively prohibit redistribution of this draft paper other than for review purposes.

Citation

Please cite as:

Xiaopeng W, Jiaxin Z, Chang L, Haowen Z, Guanduo S, Jingming Z, Haijun Y, Haijun Y

Deciphering Lactate Metabolism in Colorectal Cancer: Prognostic Modeling, Immune Infiltration, and Gene Mutation Insights

Journal of Medical Internet Research

DOI: 10.2196/14886

URL: https://preprints.jmir.org/preprint/11848

PMID: 31789598

PMCID: 6352016

Deciphering Lactate Metabolism in Colorectal Cancer: Prognostic Modeling, Immune Infiltration, and Gene Mutation Insights

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