A Closed-Loop Digital Health Tool to Improve Depression Care in Multiple Sclerosis: Iterative Design and Cross-Sectional Pilot Randomized Controlled Trial and its Impact on Depression Care

Kyra Henderson   ¹ , BA ;   Jennifer Reihm   ¹ , MPA ;   Kanishka Koshal   ¹ , MSPH ;   Jaeleene Wijangco   ¹ , BS ;   Narender Sara   ¹ , MBA, MS ;   Nicolette Miller   ¹ , BS ;   Marianne Doyle   ¹ , LCSW ;   Alicia Mallory   ¹ , BA, BSN, RN ;   Judith Sheridan   ¹ , PhD ;   Chu-Yueh Guo   ¹ , MD ;   Lauren Oommen   ¹ , DO ;   Katherine P Rankin   ¹ , PhD ;   Stephan Sanders   ¹ , PhD ;   Anthony Feinstein   ² , MPhil, PhD ;   Christina Mangurian   ³ , MAS, MD ;   Riley Bove   ¹ , MMSc, MD

¹ Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States

² Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

³ Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States