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Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study

Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: Protocol for a Mixed Methods Feasibility Study

ADRD is characterized by a progressive loss of cognition and function that eventually results in loss of independence and mortality. Currently, there are no curative treatments for ADRD. Thus, there is increased focus on nonpharmacological interventions that target modifiable risk factors for cognitive decline and dementia in older adults.

Chava Pollak, Helena M Blumen, Lily Zhou, Jennifer Wong, Ying Jin, Atul Bhattiprolu, Sophie Anfang, Mirnova E Ceïde

JMIR Res Protoc 2025;14:e70518

Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

Although the relationship between Phe and cognitive functioning is more like a continuum, such that higher Phe is associated with greater impairment in cognitive functioning, in general, patients with PKU with Phe levels above 600 mmol/L demonstrate impaired cognition [3,4] and poor frontal lobe function [10].

Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

JMIR Form Res 2025;9:e63644

Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review

Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review

This shift toward the earliest AD stages highlights the need for new tools that provide outcome measures of cognition that are adequate for use in these early disease stages in the realm of early detection, diagnosis, disease monitoring, and evaluation of treatment effects [13-17]. In addition, to enable large-scale decentralized prevention, intervention, or disease-monitoring initiatives, tools are required that enable remote, time-efficient, and reliable assessment of cognition.

Rosanne L van den Berg, Sophie M van der Landen, Matthijs J Keijzer, Aniek M van Gils, Maureen van Dam, Kirsten A Ziesemer, Roos J Jutten, John E Harrison, Casper de Boer, Wiesje M van der Flier, Sietske AM Sikkes

J Med Internet Res 2025;27:e65297

Domain-Specific Evaluation of Exergame Metrics Among Older Adults With Mild Neurocognitive Disorder: Secondary Analysis of 2 Randomized Controlled Trials

Domain-Specific Evaluation of Exergame Metrics Among Older Adults With Mild Neurocognitive Disorder: Secondary Analysis of 2 Randomized Controlled Trials

Reference 12: Effects of exergames on brain and cognition in older adults: a review based on a new categorization Reference 26: Effects of multi-component non-pharmacological interventions on cognition in participants Reference 48: Factors for optimizing intervention programs for cognition in older adults: the value of Wechsler memory scale. 4th edition(https://www.pearsonassessments.com/en-us/Store/Professional-Assessments/Cognition Reference 106: Is there a preferred mode of exercise for cognition enhancement in older age?cognition

Wanda Kaiser, Eling D de Bruin, Patrick Manser

JMIR Serious Games 2025;13:e65878

Perceptions of the Use of Mobile Apps to Assess Sleep-Dependent Memory in Older Adults With Subjective and Objective Cognitive Impairment: Focus Group Approach

Perceptions of the Use of Mobile Apps to Assess Sleep-Dependent Memory in Older Adults With Subjective and Objective Cognitive Impairment: Focus Group Approach

The adoption of digital health technology in older adults has been increasing [15], including by individuals with subjective concerns about their cognition and those with MCI [16]. However, when considering new app-based approaches, barriers and facilitators that influence adoption and effective use must be identified [17].

Aaron Lam, Simone Simonetti, Angela D'Rozario, David Ireland, DanaKai Bradford, Jurgen Fripp, Sharon L Naismith

JMIR Aging 2025;8:e68147

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

Regular Tai Chi practice is beneficial for relieving fatigue and improving cognition in CFS, and it is more effective than general aerobic exercise. To assess the clinical effects of Tai Chi on fatigue relief and cognitive function improvement, this study aims to design a randomized, parallel, single-blind clinical trial.

Bin Wang, Xiaodong Zhang, Ping Lu, Pingping Sun, Tianxiang He

JMIR Res Protoc 2025;14:e65958

Association Between Sleep Duration and Cognitive Frailty in Older Chinese Adults: Prospective Cohort Study

Association Between Sleep Duration and Cognitive Frailty in Older Chinese Adults: Prospective Cohort Study

For this set of analyses, we included 11,303 participants who had cognition and physical frailty assessments at baseline. We then examined whether baseline sleep duration and sleep quality, as well as change in sleep duration, were associated with the future development of cognitive frailty.

Ruixue Cai, Jianqian Chao, Chenlu Gao, Lei Gao, Kun Hu, Peng Li

JMIR Aging 2025;8:e65183

Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

In terms of beneficial outcomes, we collected evidence in the domains of psychological distress, cognition, and physiological health. In addition, we examined methodological limitations (eg, the possibility of placebo effects) and possible moderators like clinical conditions. Our meta-analysis is the first systematic evaluation of whether cg NF with mindfulness meditation enhances outcomes and processes related to mindfulness.

Isaac Treves, Zia Bajwa, Keara D Greene, Paul A Bloom, Nayoung Kim, Emma Wool, Simon B Goldberg, Susan Whitfield-Gabrieli, Randy P Auerbach

J Med Internet Res 2025;27:e68204

The Impact of Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation in Pregnant Women Toward the Intelligence Status of Early Childhood: Protocol for a Systematic Review and Meta-Analysis

The Impact of Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation in Pregnant Women Toward the Intelligence Status of Early Childhood: Protocol for a Systematic Review and Meta-Analysis

The outcome of children’s intelligence can be assessed using various tools that measure factors like cognition, attention, motor skills, language, behavior, vision, hearing, social-emotional, and neurodevelopment. We will conduct a systematic review in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) [20].

Han Yin Lim, Mohammad Adi Mohammad Fadzil, Suraiami Mustar, Imanul Hassan Abdul Shukor, Wan Ahmad Syazani Mohamed

JMIR Res Protoc 2025;14:e60417

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Even among adults with normal cognition, rhythm fragmentation correlates with greater brain amyloid deposition [3,4]. Over time, 24-hour rhythm fragmentation has been associated with increased risk and faster rates of cognitive decline in people with MCI and mild-to-moderate dementia [1,5] .

Caleb D Jones, Rachel Wasilko, Gehui Zhang, Katie L Stone, Swathi Gujral, Juleen Rodakowski, Stephen F Smagula

JMIR Aging 2025;8:e67294