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Evaluation of the Effectiveness of Close-Knit Medical Alliances on the Integration of HIV Prevention and Treatment in County-Level Areas in China: Protocol for a Delphi Study

Evaluation of the Effectiveness of Close-Knit Medical Alliances on the Integration of HIV Prevention and Treatment in County-Level Areas in China: Protocol for a Delphi Study

This approach is critical for transforming HIV into a manageable chronic condition, allowing people living with HIV to lead long and healthy lives. China faces considerable challenges in HIV prevention and control, particularly in integrating medical and preventive services in rural and county-level areas.

Sixian Du, Yaqing Liu, Qilian Luo, Rongcai Dai, Jiayan He, Yong Yang, Yiqing Yang

JMIR Res Protoc 2025;14:e76420


Mobile Apps for HIV and Sexually Transmitted Infection Prevention in Canada, Mexico, and the United States: Environmental Scan

Mobile Apps for HIV and Sexually Transmitted Infection Prevention in Canada, Mexico, and the United States: Environmental Scan

These vulnerabilities not only undermine individual health but also contribute to the transmission of HIV, with significant public health implications for both migrant communities and their host countries [14,15]. The compounded risks underscore the urgent need for effective HIV and STI prevention strategies that can reach these transient populations.

Higinio Fernández-Sánchez, Javier Salazar-Alberto, Jhan Carlos Manuel Fernández-Delgado, Annalynn Galvin, Michael J Mugavero, Carlos E Rodriguez-Diaz, Diane Santa Maria

JMIR Mhealth Uhealth 2025;13:e72009


Supporting Oral and Long-Acting HIV Preexposure Prophylaxis Decision-Making Among Pregnant Women (MyChoice Intervention): Protocol for 2 Pilot Randomized Controlled Trials

Supporting Oral and Long-Acting HIV Preexposure Prophylaxis Decision-Making Among Pregnant Women (MyChoice Intervention): Protocol for 2 Pilot Randomized Controlled Trials

HIV preexposure prophylaxis (Pr EP) is a proven yet underused tool to eliminate mother-to-child HIV transmission. With high adherence, daily oral Pr EP with tenofovir-emtricitabine is highly efficacious in preventing HIV infection [1-3], including among expectant mothers, and it is safe to use during pregnancy and breastfeeding [4]. However, despite its promise, significant implementation challenges exist [5].

Friday Saidi, Symone Welch, Twambilile Phanga, Carlie Sulpizio, Lusubiro Paile, Doris Ngo’ma, Mercy Tsidya, Mary Chindebvu, Grace Nkhoma, Lovemore Nkhalamba, Ivy Kaliati, Nomthata Mkochi, Humphrey Chakala, Wiza Kumwenda, Agatha Bula, Picrina Winner, Tapiwa Munthali, Alinda Nyamaizi, Jessica Keys, Suzanne Maman, Lisa Pearce, Carol Golin, Benjamin H Chi, Lauren M Hill

JMIR Res Protoc 2025;14:e76442


Feasibility of mHealth Strategies to Promote Use of Wrist-Worn Alcohol Biosensors Among Young Adults With HIV: Protocol for the Engage Microrandomized Trial

Feasibility of mHealth Strategies to Promote Use of Wrist-Worn Alcohol Biosensors Among Young Adults With HIV: Protocol for the Engage Microrandomized Trial

Alcohol consumption is especially common among young adults with HIV. Research shows that young adults with HIV exhibit disproportionately high rates of alcohol use disorder (AUD) compared to the general youth population, as well as other age groups of people with HIV [4].

Stephanie M Carpenter, Stuart Case, Mia Liza A Lustria, Laura Reid Marks, Qinggang Yu, Karen MacDonell, Sylvie Naar, Yan Wang

JMIR Res Protoc 2025;14:e69966


Feasibility and Acceptability of a mHealth Patient Navigation Intervention to Increase Pre-Exposure Prophylaxis Uptake in Racially and Ethnically Diverse Sexual and Gender Minority Youth in Los Angeles (PrEPresent): Pilot Randomized Controlled Trial

Feasibility and Acceptability of a mHealth Patient Navigation Intervention to Increase Pre-Exposure Prophylaxis Uptake in Racially and Ethnically Diverse Sexual and Gender Minority Youth in Los Angeles (PrEPresent): Pilot Randomized Controlled Trial

Despite a decrease in new HIV acquisitions within cisgender men (those who identify their gender with their sex assigned at birth) in the LGBTQ+ community, 67% of new HIV acquisitions are still attributed to sexual interactions within this group. Young sexual minority men, those between the ages of 13 and 34, make up just over half (56%) of new diagnoses [1].

Sam Calvetti, Bryan Lei, Jacob B Stocks, Matthew T Rosso, Manuel Puentes, Ramon Durazo-Arvizu, Lindsay Slay, Michele D Kipke, Lisa B Hightow-Weidman

JMIR Form Res 2025;9:e69255


Lessons Learned Identifying and Controlling Fraudulent Participation in Online Randomized Trials

Lessons Learned Identifying and Controlling Fraudulent Participation in Online Randomized Trials

The Boston ARCH Comorbidity Center, known as ARCHER (Addressing Related Comorbidities for HIV by Employing Remote Technologies), is a research center funded by the National Institute on Alcohol Abuse and Alcoholism.

Robert Siebers, Kara M Magane, Hattie Slayton, Skylar Karzhevsky, Tibor P Palfai, Ana M Abrantes, Lisa M Quintiliani, Michael D Stein

J Med Internet Res 2025;27:e77512


Formative Evaluation of an HIV Prevention App tailored for Latino Men Who Have Sex With Men: Acceptability and Usability Study

Formative Evaluation of an HIV Prevention App tailored for Latino Men Who Have Sex With Men: Acceptability and Usability Study

It features in-app health screenings that direct users to appropriate services: HIV testing and Pr EP service locator; mail delivery of condoms, lubricant, and home HIV and sexually transmitted infection tests; and customizable HIV testing and Pr EP care maintenance plans [19]. To date, no comprehensive HIV prevention app has been customized to address the Pr EP accessibility barriers faced by Latino MSM, representing an important research gap.

Valeria D Cantos, Humberto Posada-Orozco, Isabella Batina, Natalie Sanchez, Eric Rangel, Patrick S Sullivan, Andres Camacho-Gonzalez, Aaron J Siegler

JMIR Form Res 2025;9:e74208


Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

Testing the Efficacy of 2 Interventions to Improve Health Outcomes and Quality of Life Among Rural Older Adults Living With HIV: Protocol for a Randomized Controlled Trial

In the United States, more than 59,000 people living with HIV reside in rural areas, and approximately 2000 rural residents are newly diagnosed with HIV each year [1]. Rural people living with HIV have higher mortality rates than nonrural people living with HIV [2,3] and are more likely to have mental illness, substance dependence, and social isolation [4-8].

Andrew E Petroll, Sabina Hirshfield, Katherine G Quinn, Steven A John, Olivia H Algiers, Liam Randall, David Wyley Long, Timothy McAuliffe, Jennifer L Walsh

JMIR Res Protoc 2025;14:e71429


Just-in-Time Adaptive Intervention to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness (MY-RIDE): Protocol for a Randomized Controlled Trial

Just-in-Time Adaptive Intervention to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness (MY-RIDE): Protocol for a Randomized Controlled Trial

Yet, homeless youth lack adequate access to HIV prevention, including highly effective pre- and postexposure prophylaxis medications (ie, pre-exposure prophylaxis medication [Pr EP] and postexposure prophylaxis medication [n PEP]) [8]. Despite the high proportion of homeless youth found to be eligible for Pr EP (84%) in 1 large study, only 29% knew what Pr EP was, and very few (14%) reported that they were actively trying to prevent HIV [9]. Substance use and stress increase the risk for HIV [10,11].

Diane Santa Maria, Nikhil Padhye, Michael Businelle, Natasha Slesnick, Stefani Ricondo, Marguerita Lightfoot

JMIR Res Protoc 2025;14:e78006


Acceptability, Needs, Concerns, and Barriers to Digital-Based Interventions for the Prevention of Mother-to-Child Transmission of HIV: Systematic Review and Qualitative Meta-Aggregation

Acceptability, Needs, Concerns, and Barriers to Digital-Based Interventions for the Prevention of Mother-to-Child Transmission of HIV: Systematic Review and Qualitative Meta-Aggregation

Since the onset of the epidemic, an estimated 88.4 million individuals are living with HIV, and approximately 42.3 million have died from HIV-related causes [1]. By the end of 2023, around 39.9 million individuals were living with HIV globally [1]. Although the global HIV prevalence among adults aged 15‐49 years is approximately 0.8%, the burden of the epidemic varies significantly across regions and countries [1].

Sidik Maulana, Kusman Ibrahim, Rachel H A Arbing, Iqbal Pramukti, Annisa Dewi Nugrahani, Luh Nik Armini, Muhammad Iqhrammullah, Wei-Ti Chen

JMIR Med Inform 2025;13:e64816