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Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study

Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study

China is one of the most severely affected countries, with the highest number of HCV infections globally [4]. In recent years, the global epidemic trend of HCV has garnered significant attention [5]. Hepatitis C is primarily transmitted through blood contact and is associated with severe complications, including cirrhosis and liver cancer [6]. The prevalence and distribution of various HCV genotypes vary across different regions [7].

Lin Lin, Guoyong Wang, Lianzheng Hao, Tingbin Yan

JMIR Med Inform 2025;13:e60207

Natural Language Processing for Identification of Hospitalized People Who Use Drugs: Cohort Study

Natural Language Processing for Identification of Hospitalized People Who Use Drugs: Cohort Study

Some researchers have used the hepatitis C virus (HCV) codes as a marker of drug use, although there are a substantial number of people with HCV who do not currently use drugs or have ever used drugs [16,17]. The barrier to identifying PWUD can potentially be addressed with natural language processing (NLP), to leverage artificial intelligence (AI) algorithms for interpretation of the written text in a context-relevant manner [18].

Taisuke Sato, Emily D Grussing, Ruchi Patel, Jessica Ridgway, Joji Suzuki, Benjamin Sweigart, Robert Miller, Alysse G Wurcel

JMIR AI 2025;4:e63147

Sustained Virological Response as a Surrogate Marker for Mortality, Decompensated Cirrhosis, or Hepatocellular Carcinoma in People With Chronic Hepatitis C Virus Infection Treated With Direct-Acting Antivirals: Protocol for a Bayesian and Causal Mediation Analysis

Sustained Virological Response as a Surrogate Marker for Mortality, Decompensated Cirrhosis, or Hepatocellular Carcinoma in People With Chronic Hepatitis C Virus Infection Treated With Direct-Acting Antivirals: Protocol for a Bayesian and Causal Mediation Analysis

Most hepatitis C virus (HCV) infections extend beyond the first 6 months (acute phase) and become chronic infections [1]. An estimated 50 million people have chronic HCV infections globally [2]. Every year, 1 million people acquire new chronic HCV infections [2]. Major clinical complications of chronic HCV infection include cirrhosis, hepatocellular carcinoma (primary liver cancer), and death resulting from the complications [3].

Kurinchi Selvan Gurusamy, Christian Gluud

JMIR Res Protoc 2025;14:e68113

Community Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial—Protocol for a Mixed Methods Study

Community Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial—Protocol for a Mixed Methods Study

This study also identified two significant risk factors for HCV infection: having a family member positive for HCV and the use of intravenous medication in the past 5 years [10]. These efforts underscore the complexity of the hepatitis epidemic in Cambodia and the multifaceted approach required to address it.

Emilie Mosnier, Olivier Ségéral, Sansothy Neth, Luis Sagaon-Teyssier, Dyna Khuon, Chan Leakhena Phoeung, Sovatha Mam, Chhingsrean Chhay, Kimeang Heang, Jean Charles Duclos-Vallée, Vonthanak Saphonn

JMIR Res Protoc 2024;13:e63376

Understanding Users’ Engagement in a Provider-Created Mobile App for Training to Advance Hepatitis C Care: Knowledge Assessment Survey Study

Understanding Users’ Engagement in a Provider-Created Mobile App for Training to Advance Hepatitis C Care: Knowledge Assessment Survey Study

Existing literature available for HCV education is focused on the comanagement of opioid use disorders and do not provide targeted information on general HCV treatment and cure [17-19]. In response to these gaps as well as needs assessment and feedback from multidisciplinary stakeholders, we developed an app to address the lack of HCV educational resources available to patients and health care supportive staff. The app guides the user through the HCV treatment stages in a self-exploratory way.

Maximilian Wegener, Katarzyna Sims, Ralph Brooks, Lisa Nichols, Robert Sideleau, Sharen McKay, Merceditas Villanueva

JMIR Form Res 2024;8:e52729

Care Integration for Hepatitis C Virus Treatment Through Facilitated Telemedicine Within Opioid Treatment Programs: Qualitative Study

Care Integration for Hepatitis C Virus Treatment Through Facilitated Telemedicine Within Opioid Treatment Programs: Qualitative Study

Additionally, people with OUD have high hepatitis C virus (HCV) incidence and prevalence due to injection drug use and limited access to HCV therapy [3]. To achieve HCV elimination by 2030, as proposed in several jurisdictions [4-6], HCV treatment access must increase. We sought to address restricted HCV care access for people with OUD through a randomized controlled trial of care integration using technology that is at the intersection of the internet or videoconferencing, and health care.

Suzanne S Dickerson, Saliyah J George, Ana Ventuneac, Arpan Dharia, Andrew H Talal

J Med Internet Res 2024;26:e53049

Characteristics of Hepatitis B Virus, Hepatitis C Virus, and Syphilis Coinfection in People With HIV/AIDS Contracted Through Different Sources: Retrospective Study

Characteristics of Hepatitis B Virus, Hepatitis C Virus, and Syphilis Coinfection in People With HIV/AIDS Contracted Through Different Sources: Retrospective Study

Hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis infection are also all major public health problems worldwide. HBV, HCV, and syphilis are the 3 most common infections among people living with HIV/AIDS all over the world and share similar transmission routes [2,3]. The burden of HBV, HCV, and syphilis infection in people living with HIV/AIDS is even larger than in the general population. The ever-increasing burden of these infections has become a growing concern [4].

Rongrong Yang, Rui Yuan, Xien Gui, Hengning Ke, Ke Zhuang, Hui Hu, Ling Li, Ling Feng, Xingxia Yu, Yajun Yan, Mingqi Luo

JMIR Public Health Surveill 2024;10:e46750

Hepatitis C Knowledge and Self-Reported Testing Behavior in the General Population in China: Online Cross-Sectional Survey

Hepatitis C Knowledge and Self-Reported Testing Behavior in the General Population in China: Online Cross-Sectional Survey

However, there is a lack of information about HCV testing behavior and willingness to undergo HCV screening in the general Chinese population. This study was conducted to assess HCV knowledge, self-reported HCV testing behavior, and willingness to undergo HCV screening in the general Chinese population to inform policy decision-making aimed at eliminating HCV. The characteristics of patients who have less knowledge and are less likely to undergo testing were also explored.

Yin Liu, Juan Su, Xiaoyang Wang, Huifang Xu, Hong Wang, Ruihua Kang, Liyang Zheng, Yixian Wang, Chunya Liu, Yiping Jing, Shaokai Zhang

JMIR Public Health Surveill 2023;9:e39472

Testing for Hepatitis C During Pregnancy Among Persons With Medicaid and Commercial Insurance: Cohort Study

Testing for Hepatitis C During Pregnancy Among Persons With Medicaid and Commercial Insurance: Cohort Study

HCV can be transmitted during pregnancy or delivery—an estimated 5.8% of infants born to women with HCV infection become infected [4]. Perinatal infection can result in liver disease during adulthood and sequelae such as cirrhosis and hepatocellular carcinoma [5]. The incidence of acute HCV infection in the United States increased annually from 2009 to 2019, with rates highest among adults 20-29 and 30-39 years of age, including women of childbearing age [6,7].

Mohammed A Khan, William W Thompson, Ademola Osinubi, William A Meyer 3rd, Harvey W Kaufman, Paige A Armstrong, Monique A Foster, Noele P Nelson, Carolyn Wester

JMIR Public Health Surveill 2023;9:e40783

Coproduction of Low-Barrier Hepatitis C Virus and HIV Care for People Who Use Drugs in a Rural Community: Brief Qualitative Report

Coproduction of Low-Barrier Hepatitis C Virus and HIV Care for People Who Use Drugs in a Rural Community: Brief Qualitative Report

Infections such as hepatitis C (HCV) and HIV disproportionally affect people who inject drugs. Globally, over half of people who inject drugs are infected with HCV, and nearly 1 in 5 with HIV [1-5]. Many people who inject drugs are unaware of their HCV or HIV status, and rates of accessing treatment are low. For instance, fewer than 10% of those infected with HCV receive treatment [6], increasing morbidity and contributing to ongoing virus spread [7].

Shoshana H Bardach, Amanda N Perry, Elizabeth Eccles, Elizabeth A Carpenter-Song, Ryan Fowler, Erin M Miers, Anais Ovalle, David de Gijsel

J Particip Med 2023;15:e47395