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- 17 JMIR Research Protocols
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Although no published human studies have reported any serious adverse effects attributed to tocotrienols, it is worth noting that, in animal studies, tocotrienol doses of 500 mg/kg body weight and 1000 mg/kg body weight (administered orally) were found to increase bleeding and clotting times in mice during subacute (14 days) and subchronic (42 days) investigations [88]. When these doses are converted to a human equivalent dose, they equate to 2400 mg and 4800 mg, respectively in humans.
JMIR Res Protoc 2025;14:e73039
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Currently, lifestyle modifications focusing on dietary changes, increased physical activity, weight loss, and weight maintenance are the primary initial approaches for managing NAFLD [10]. However, the lack of standardized, evidence-based interventions and limited out-of-hospital monitoring often leads to suboptimal long-term results for individuals undergoing lifestyle interventions for NAFLD.
JMIR Cardio 2025;9:e72074
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Therefore, lifestyle modifications delivered via mobile devices, especially mobile phones, present an opportunity to help people lose weight.
Several meta-analyses have evaluated the effectiveness of mobile phone apps on weight loss in adults [14-16]. However, these reviews have some limitations. First, most reviews [14-18] have primarily focused on weight and BMI, while other important outcomes, such as fat mass, blood pressure, and physical activity (PA), have also been reported in original studies.
JMIR Mhealth Uhealth 2025;13:e63313
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Successful weight loss and weight loss maintenance require adjustments to food intake and physical activity; the key behaviors targeted by most weight management interventions [1]. These interventions include a variety of behavioral and psychological strategies, ranging from calorie counting [2] to mindful eating [3] and intermittent fasting [4]. While the efficacy of many of these interventions is well-established [5], their impact on weight management remains contingent upon individual adherence.
JMIR Mhealth Uhealth 2025;13:e65260
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ACT aims to enhance psychological flexibility, a trait linked to improved psychological well-being [18,19], and has demonstrated efficacy not only in weight management but also in the treatment of various mental and somatic health conditions [20]. This is particularly relevant in obesity treatment, as individuals with obesity face an elevated risk of mental health issues and eating disorders, which can be exacerbated by weight-normative interventions that emphasize weight loss [21,22].
JMIR Ment Health 2025;12:e66518
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Multiple linear regression analysis was used to explore associations between a participant’s weight and their time spent in this study (months), for the W8 Buddy and control populations. A participant’s current weight was related to their initial study (starting) weight; therefore, the latter was included as a covariate in all linear regression models, along with gender, which was expected to be strongly associated with weight loss.
J Med Internet Res 2025;27:e62661
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Queries within this database will target individuals aged 35-65 years with a BMI≥25 kg/m2 (≥23 kg/m2 if Asian descent) [28], who have been diagnosed with prediabetes (hemoglobin A1c [Hb A1c] 5.7%-6.4%) [29] within the last 12 months, have no diagnosis of diabetes (FPG≥126 mg/d L or 2-hour plasma glucose ≥200 mg/d L or Hb A1c≥6.5% or currently taking antidiabetic drugs) [29], not currently taking weight-loss medications, not currently taking drugs known to influence glucose tolerance (steroids and antipsychotics)
JMIR Res Protoc 2025;14:e59842
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These cultural differences in dietary intake may contribute to distinct obesity rates, public attitudes toward body image, and dietary practices for weight loss.
Therefore, this study aimed to examine frequently shared content about body weight on X, with a particular focus on dietary recommendations for weight loss.
J Med Internet Res 2025;27:e64739
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Furthermore, only 3 of these studies used theory-based approaches [12], and all used weight-centric messaging.
Since 2020, more than 100 organizations worldwide, including scientific societies and academic institutions, have endorsed joint international statements to eliminate weight stigma [16]. Non–weight-centric approaches, which emphasize overall health and well-being rather than solely focusing on weight loss, have gained traction in school-based obesity interventions [17].
JMIR Pediatr Parent 2025;8:e67213
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Desire for weight-focused content tailored to the breast cancer experience (“It wasn’t what I was expecting”)
- Style of articles was enjoyed
- Too much focus on emotional content, not enough on weight (loss)
- Desire for increased tailoring to the breast cancer experience
3.
JMIR Cancer 2024;10:e48170
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