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A Neuroaffirmative, Self-Determination Theory–Based Psychosocial Intervention for Adults With Attention-Deficit/Hyperactivity Disorder: Randomized Feasibility Study

A Neuroaffirmative, Self-Determination Theory–Based Psychosocial Intervention for Adults With Attention-Deficit/Hyperactivity Disorder: Randomized Feasibility Study

Consequently, treatment recommendations from bodies such as the National Institute for Health and Care Excellence prioritize pharmacotherapy, which, while beneficial for many, often leaves patients with significant residual symptoms and functional impairment [15,32]. The primary evidence-based nonpharmacological treatment, cognitive behavioral therapy (CBT), is also rooted in this deficit model [7,15,32,33].

Rebecca Elizabeth Champ, Rita Wengorovius Meneses, Marios Adamou, Warren Gillibrand, Sally Arrey, Barry Tolchard

JMIR Form Res 2025;9:e69943


Comparing Generative Artificial Intelligence and Mental Health Professionals for Clinical Decision-Making With Trauma-Exposed Populations: Vignette-Based Experimental Study

Comparing Generative Artificial Intelligence and Mental Health Professionals for Clinical Decision-Making With Trauma-Exposed Populations: Vignette-Based Experimental Study

Trauma-related diagnostic overshadowing for these treatment ratings was defined as lower appropriateness ratings for the target treatment (ERP for OCD case; MI for SUD case) or higher ratings for a PTSD-specific treatment (CPT) when trauma exposure was present versus absent. Finally, respondents selected the most appropriate treatment from the list of treatments.

Katherine E Wislocki, Sabahat Sami, Gahl Liberzon, Alyson K Zalta

JMIR Ment Health 2025;12:e80801


Internet-Delivered Psychological Treatment for Parents With Health Anxiety by Proxy: Replicated Randomized Single-Case Experimental Design

Internet-Delivered Psychological Treatment for Parents With Health Anxiety by Proxy: Replicated Randomized Single-Case Experimental Design

The symptom questionnaires were answered 4 times during the study: at the beginning of the baseline period, at start of treatment, at end of treatment, and at follow-up except for feasibility measures, which were only answered at the end of treatment (see Figure 1). The HAPYS assessed HA by proxy.

Katrine Ingeman, Ditte Hoffmann Frydendal, Lisbeth Frostholm, Ellen Bjerre-Nielsen, Kaare Bro Wellnitz, Patrick Onghena, Kristi Wright, Charlotte Ulrikka Rask

JMIR Form Res 2025;9:e65396


Large Language Models in Lung Cancer: Systematic Review

Large Language Models in Lung Cancer: Systematic Review

Early detection and accurate treatment are essential to improving survival [3,4], and low-dose computed tomography (CT) screening has been shown to reduce mortality [5,6]. In recent years, integrated full-cycle management—covering prevention, screening, diagnosis, treatment, and supportive care—has been promoted to improve both survival and quality of life [7,8]. However, this approach requires complex workflows and large-scale data processing, placing heavy demands on medical resources and personnel.

Ruikang Zhong, Siyi Chen, Zexing Li, Tangke Gao, Yisha Su, Wenzheng Zhang, Dianna Liu, Lei Gao, Kaiwen Hu

J Med Internet Res 2025;27:e74177


Automated Literature Screening for Hepatocellular Carcinoma Treatment Through Integration of 3 Large Language Models: Methodological Study

Automated Literature Screening for Hepatocellular Carcinoma Treatment Through Integration of 3 Large Language Models: Methodological Study

This randomized controlled trial (RCT) demonstrated that the single tremelimumab regular interval durvalumab regimen, a combination of a single high dose of tremelimumab given as a first-line treatment followed by maintenance treatment with durvalumab, significantly improved overall survival and constitutes a new treatment option [12]. As such, the timely updating of information is of paramount importance, as it facilitates the refinement of guidelines and the evolution of treatment plans.

Chen Pan, Wei Lu, Bingliang Chen, Gang Zhang, Zhiming Yang, Jingcheng Hao

JMIR Med Inform 2025;13:e76252


How to Improve Pancreatic Cancer Network Care Using a Human-Centered Design Sprint

How to Improve Pancreatic Cancer Network Care Using a Human-Centered Design Sprint

In the Netherlands, centers that do not meet the volume standards for certain cancer operations, the non-expert centers, are required to refer patients to expert centers for treatment advice and surgery. However, these non-expert centers, or referring hospitals, play a large role in the diagnostic workup and provision of other parts of care, such as adjuvant chemotherapy or supportive care. The expert center together with the non-expert centers form a cancer network.

Jana S Hopstaken, Mats Koeneman, Robin Hooijer, Concha C van Rijssel, Theo van Voorthuizen, Frank A Oort, Charlotte F J M Blanken, Martijn de Groot, Cees J H M van Laarhoven, Martijn W J Stommel

J Med Internet Res 2025;27:e55598


Information Needs of Patients With Head and Neck Cancer and Their Supports in Relation to Treatment Management Choices: Scoping Review

Information Needs of Patients With Head and Neck Cancer and Their Supports in Relation to Treatment Management Choices: Scoping Review

Of the 30 articles, patients also desired more information on treatment options in 6 (20%) articles [12,15,17,19,21,28]. Specifically, more information on the advantages and potential risks of various treatment options was needed [15,17,19].

Eleah Stringer, Lily Hallett Rio, Lorraine Leitz, Eitan Prisman, Elizabeth Borycki, Andre Kushniruk, Jonathan Livergant, Sally Smith

JMIR Cancer 2025;11:e64108


Identifying Adaptations to an mHealth Alcohol Reduction Intervention for Reducing Alcohol Use in Adolescent and Young Adult Cancer Survivors: Qualitative Study

Identifying Adaptations to an mHealth Alcohol Reduction Intervention for Reducing Alcohol Use in Adolescent and Young Adult Cancer Survivors: Qualitative Study

We focused on the posttreatment period to ensure survivors had experienced sufficient time to establish more routine drinking patterns, as well as to avoid the likelihood that active cancer treatment side effects may impact drinking levels [15,16]. In addition, we specifically examined rural adolescent and young adult cancer survivor experiences and needs to ensure the resulting intervention would reach this underserved, vulnerable population.

Kimberly Haney, Tia Borger, Vilma Bursac, Caryn Sorge, Brent Shelton, John Salsman, Laurie McLouth, Carolyn Lauckner

JMIR Cancer 2025;11:e59949