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Coaches used a transdiagnostic approach to case conceptualization and incorporated skills associated with evidence-based therapies such as acceptance and commitment therapy and cognitive behavioral therapy. Coaches had access to users’ DASS-21 responses, which they reviewed with users in session, to help focus sessions and as a means of tracking progress over time.
JMIR Form Res 2025;9:e71346
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transdiagnosticTransdiagnostic Mental Health Interventions
JMIR Ment Health 2025;12:e79296
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Transdiagnostic interventions, such as the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders [39], operate under the premise that internalizing or emotional disorders can be functionally treated as a singular syndrome, with overlapping symptoms and risk factors originating from variances in emotional reactivity and regulation [40,41].
JMIR Res Protoc 2025;14:e74080
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Fortunately, there are many effective treatments for depression and anxiety that either target specific disorders or use a transdiagnostic approach [5]. However, several barriers affect access to treatment. These include high out-of-pocket costs and inconsistencies in the quality and type of care received [1]. Concerns about seeking help in person due to negative beliefs and stigma surrounding mental illness also play a role [6].
JMIR Hum Factors 2025;12:e69499
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Meanwhile, by showing that perfectionism is negatively related to the PUI symptom cluster, our findings extend previous assumptions on the potential protective role of perfectionism (underpinned by conscientiousness) in problematic alcohol use [44] to suggest that such a protective effect may be transdiagnostic across substance use and behavioral addictions.
Current findings addressed several key research priorities identified by experts [1,2].
J Med Internet Res 2025;27:e66191
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A burgeoning literature suggests that cognitive remediation may be a promising transdiagnostic intervention approach [28,47-55]. Working memory training has been found to reduce the recurrence of mood episodes among patients with remitted MDD, with stronger protective effects—apparent up to 2 years after the intervention—for those who reported reduced rumination after training [52,56].
JMIR Res Protoc 2025;14:e54221
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This study evaluates a peer-supported, transdiagnostic m Health program for trauma-exposed veterans. Given the frequency of comorbid symptomatology among trauma-exposed populations [1,28], a transdiagnostic approach, if successful, provides the opportunity for broad use across various trauma-exposed populations with diverse needs. Moreover, different types of symptoms share issues with emotion regulation and psychosocial functioning, making these difficulties important treatment targets.
J Med Internet Res 2024;26:e52130
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Due to high rates of comorbidity between mental disorders in university student populations [35], transdiagnostic approaches that deliver therapeutic content targeting the common mechanisms that underlie mental disorders may have more clinical utility than disorder-specific approaches.
J Med Internet Res 2024;26:e53598
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Transdiagnostic web-based approaches may broaden the scope and impact of interventions. This is particularly relevant given the high comorbidity of symptoms among students [5]. There is a growing consensus that depression and anxiety, although often classified as distinct disorders, share common etiological and perpetuating factors, such as proneness to internalization and high levels of negative affect [22,23].
JMIR Ment Health 2024;11:e50503
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This was the first online transdiagnostic prevention program targeting the LGB group based on the ACT framework. Despite previous calls to use standard ACT [40] or affirmative ACT [41] for LGBTQ+ communities, this is the first ACT-inspired open trial tailored for LGBTQ+ people. It is not, however, the first mental health program tailored to the LGBTQ+ community. For example, Pachankis et al [26] used a 10-session LGBTQ+ tailored CBT.
JMIR Form Res 2024;8:e56198
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