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Skip search results from other journals and go to results- 9 Journal of Medical Internet Research
- 7 JMIR Research Protocols
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- 2 JMIR Aging
- 2 JMIR Formative Research
- 2 JMIR Medical Informatics
- 1 JMIR mHealth and uHealth
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However, the exact cause of primary sarcopenia is not fully understood yet. Recent studies suggested that cellular aging [7], mitochondrial disorder [8], decreased physical activity [9], and excessive caloric intake could accelerate the progression of sarcopenia. Moreover, an imbalance of oxygen in the body may contribute to the development of sarcopenia as well [10].
Sarcopenia afflicts not only the older people but also the patients with immune diseases.
Interact J Med Res 2025;14:e64456
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Sarcopenia significantly influences the secretion and metabolism of the body, such as glucose, glycogen, and lipid metabolism, as well as the secretion of a variety of cytokines [5]. Therefore, clinical data from laboratory information may provide supplementary information for the diagnosis of sarcopenia. Besides the metabolic changes, the pathogenesis of sarcopenia primarily encompasses fiber loss, atrophy, and increased infiltration of adipose and connective tissue [6,7].
J Med Internet Res 2025;27:e70545
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Sarcopenia
Sarcopenia risk will be assessed before and after each research period by the change of total score of the Greek version [110] of Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls Scale [111], which is a 0 to 10 self-reporting screening tool of five 0- to 2-point components (strength, assistance walking, rise from a chair, climb stairs, and number of falls) with 0 to 3 indicating no risk for sarcopenia, and ≥4 indicating risk of sarcopenia.
JMIR Res Protoc 2025;14:e65490
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According to the 2019 Asian Working Group for Sarcopenia (AWGS) consensus update, the diagnosis of sarcopenia should be based on changes in muscle strength, physical performance, and muscle mass, with case findings leading to a comprehensive assessment and diagnosis in primary care or community preventive settings [8-10].
JMIR Form Res 2025;9:e63928
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Thank you for your reading of our article “A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial” [1]. We are truly gratified that our study has garnered your attention and interest and has sparked meaningful discussion. In response to the points raised by the authors [2], our answers are as follows.
J Med Internet Res 2025;27:e73174
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Dear Editor:
We are writing to share our thoughts on the article “A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial” [1] published in the Journal of Medical Internet Research. This research presents a significant exploration into the rehabilitation of older adults with sarcopenia, comparing a mobile app–based telerehabilitation approach with traditional in-person rehabilitation.
J Med Internet Res 2025;27:e71845
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Age-related muscle wasting and neurodegeneration, clinically presented as sarcopenia and dementia, respectively, are the major drivers of frailty, falls, and disability in older adults worldwide [1]. Sarcopenia is characterized by loss of muscle mass, strength, and function in older adults. Aging is the leading risk factor, but conditions such as chronic diseases, inflammation, sedentarism, and malnutrition promote sarcopenia onset and progression [2].
JMIR Aging 2025;8:e63686
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With advancing age, many people are experiencing sarcopenia. Sarcopenia can be defined as the age-related decline in skeletal muscle mass and function, highlighting the importance of advancing age as a factor of sarcopenia [2]. Sarcopenia is a natural part of the aging process, but its progression can be hastened by several factors, such as inflammation associated with aging (inflammaging), chronic diseases, lack of physical activity, inadequate nutrition, unintentional weight loss, and disuse events [3].
JMIR Form Res 2025;9:e54392
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Sarcopenia is characterized by a substantial reduction in skeletal muscle mass and function. This condition heightens the risk of falls, fractures, and physical disability and is closely linked to a poorer quality of life, as well as increased mortality rates [3,4].
According to a systematic review from 2022, the prevalence of sarcopenia worldwide is estimated to be 8%-36% in individuals under the age of 60 years and 10%-27% in those over 60 years [5].
J Med Internet Res 2025;27:e67846
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According to the AWGS 2019, sarcopenia is defined as a loss of skeletal muscle mass and a loss of muscle strength or physical capacity, while severe sarcopenia is defined as a loss of skeletal muscle mass plus a loss of both muscle strength and physical capacity; moreover, severe sarcopenia is defined as a loss of both muscle strength and physical performance in addition to a loss of skeletal muscle mass.
Interact J Med Res 2024;13:e58038
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