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Skip search results from other journals and go to results- 6 JMIR Research Protocols
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Several studies evaluating the effect of acidic drinks on saliva have used this approach to monitor real-time fluctuations in p H across multiple time points [11]. In this context, the ability of saliva to restore p H levels after an acidic challenge is essential for maintaining enamel integrity.
JMIR Res Protoc 2025;14:e65253
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Saliva is an easily accessible bodily fluid and one example of a noninvasive sample that has the potential for biomarker detection in NPC. Saliva contains more than 3000 types of RNA that can be used as biomarkers for the noninvasive diagnosis of NPC [7]. Therefore, the molecules contained in saliva can potentially be used to detect several diseases, including NPC. [11]
Most previous studies have explored alternative methods for the detection of NPC.
JMIR Res Protoc 2025;14:e69484
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A: Sweatband to ensure tight fitting of Dreem 2; B: Dreem 2 electroencephalography (EEG) headband; C: Nonin 3150 Wrist Ox 2 oximeter; D: USB-C charging cable (for Dreem 2 and AX3); E: Axivity AX3 actigraph and wrist strap; F: Saliva collection aid for passive drool; G: Collection tube for passive drool; H: Storage tube for oral swab; I: Oral swab.
JMIR Aging 2025;8:e72824
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To address this research gap, we propose a proof-of-concept feasibility study (NOVA study) to evaluate the relationship between the levels of serum inflammatory biomarkers and those measured noninvasively in urine, sweat, saliva, exhaled breath, core body temperature, and stool in patients with systemic inflammation.
JMIR Res Protoc 2024;13:e62877
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Feasibility was defined by a retention rate (>80%) and adherence rates (>70%) for the assessment measures [18,19], such as survey responses, saliva collections, sweat collection, and HRV sensor wear. Retention was defined as the percentage of participants who completed the baseline survey and completed the 96-hour FTX. The adherence to saliva sampling was defined as the percentage of the collected saliva sample out of a total of 12 collections (4 per day for 3 days).
JMIR Form Res 2024;8:e60925
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Research on the detection of other respiratory viruses in saliva [25,26] and previous work by our group with saliva and SARS-Co V-2 [27] piqued our interest in this approach. Although there was no validated technique for using saliva samples at the beginning of this work and serious doubts about its suitability for diagnosing SARS-Co V-2, various studies had postulated saliva as the preferred alternative sample [24,28-31]. Erratic results were observed when comparing saliva and NPSs [24,32-34].
JMIR Public Health Surveill 2024;10:e54503
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At the end of this stage, we had a web-based tool that could be used to help with self-assessment of sore throat (and taking throat swabs and saliva samples).
J Med Internet Res 2023;25:e39791
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Saliva samples will be collected according to the manufacturer’s instructions. If no specific instruction is provided or for RT-PCR, the sample will be collected by instructing the person being tested to massage the glands on both sides of the jaw and them sampling the saliva produced from the parotid, submandibular, and sublingual glands.
JMIR Res Protoc 2022;11(5):e35706
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Interestingly, antibodies are also secreted by mucosal tissues, and SARS-Co V-2–specific antibodies can be detected in saliva and other body fluids [13]. Saliva sampling as a noninvasive method (ie, it does not cause disturbance) for SARS-Co V-2 antibody measurements and is an elegant approach to rapidly assess the prevalence of SARS-Co V-2 infection in vulnerable cohorts at numbers appropriate for epidemiologic investigations [14].
JMIR Res Protoc 2021;10(10):e27739
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Part III of the study builds up a liquid biobank from biosamples (blood, urine, stool, saliva) of study part II participants, with samples taken prior to endoscopy. The main objective of study part III is the evaluation of less invasive methods of CRC screening and further characterization of detected neoplasms and defining biomarkers or biomarker panels of different composition (such as proteins, metabolites, DNA, micro RNA, methylation markers) obtained via different -omics platforms.
DARIO study design.
JMIR Res Protoc 2020;9(8):e17516
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