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An Online Family Literacy and Wellness Program for Latino Dual Language Learners: Pilot Randomized Waitlist Controlled Trial

An Online Family Literacy and Wellness Program for Latino Dual Language Learners: Pilot Randomized Waitlist Controlled Trial

Using community-engaged research strategies, we partnered with parents to refine the program and subsequently conducted a pilot randomized controlled trial (RCT). Consistent with the approach proposed by Baumann and Cabassa [19], we intentionally focused on intervention reach, design, and equity-relevant implementation outcomes. These insights can inform similar cross-sector education-health care partnerships that aim to promote equity for Latino DLLs and their families.

Kevin D Guerrero, Lucia Lakata, Daniel Lima, Caroline Mendoza, Nila Uthirasamy, Lesley M Morrow, Silvia Perez-Cortes, Maria Pellerano, Alicja Bator, Pamela Ohman Strickland, Benjamin F Crabtree, Manuel E Jimenez

JMIR Pediatr Parent 2025;8:e60764

Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

We conducted a 2-week exploratory double-blind randomized controlled trial comparing a Woebot for mood and anxiety with generative elements (Gen-W-MA, 81/160, 50.6%) against a rules-based version of this same product, that is, Woebot for mood and anxiety (W-MA, 79/160, 49.3%). W-MA is an investigational DMHI that delivers a guided self-help program using cognitive behavioral therapy, psychoeducation, and self-management tools through brief conversations with a relational agent named Woebot (Woebot Health).

Timothy R Campellone, Megan Flom, Robert M Montgomery, Lauren Bullard, Maddison C Pirner, Aaron Pavez, Michelle Morales, Devin Harper, Catherine Oddy, Tom O'Connor, Jade Daniels, Stephanie Eaneff, Valerie L Forman-Hoffman, Casey Sackett, Alison Darcy

J Med Internet Res 2025;27:e67365

Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

For the present study, 2 types of randomized studies were included. We leveraged randomized controlled trials (RCTs) with between-participant controls as well as within-participant controls (ie, participants perform mb NF and meditation only, with the order randomized). The following open questions were addressed using quantitative synthesis: (1) Is there evidence that participants are learning to regulate brain signals using neurofeedback, and reporting higher mindfulness?

Isaac Treves, Zia Bajwa, Keara D Greene, Paul A Bloom, Nayoung Kim, Emma Wool, Simon B Goldberg, Susan Whitfield-Gabrieli, Randy P Auerbach

J Med Internet Res 2025;27:e68204

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Doi et al [47] conducted a randomized controlled trial involving 142 patients with knee osteoarthritis. They found that a home-based quadriceps strengthening program involving 20 repetitions of a slow knee extension movement implemented 4 times daily for 8 weeks was as effective as nonsteroidal anti-inflammatory drugs for improved pain, stiffness, physical function, and Qo L outcomes.

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

We thus performed an exploratory, prospective, open-label, parallel, single-center, randomized controlled trial (RCT) to investigate the effectiveness of CGM on short-term, in-hospital mortality among frail and critically ill patients with COVID-19. This is an exploratory, prospective, open-label, parallel, single-center RCT.

Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

J Med Internet Res 2025;27:e67012

Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

In this study, we aimed to test whether the inclusion of tailored prompts aimed at achieving usage goals can increase the efficacy of an ICBT stress recovery intervention for health care workers in a randomized controlled trial (RCT). The “For Recovery from Stress” (FOREST) is a 6-week ICBT intervention [14], incorporating mindfulness and focused on stress recovery [15]. FOREST+ is the updated version of FOREST, designed to meet the needs of health care workers [5].

Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

JMIR Ment Health 2025;12:e62782

Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

This was a prospective randomized control trial assessing changes in the PSS and DASS-21 scores over a 12-week period. Both are validated questionnaires studied extensively in the literature [26,27]. The PSS consists of 10 items that measure the subjective feelings of the amount of stress in the participants by assessing thoughts and feelings in the previous month. Each question is scored from 0 (never) to 4 (very often) with a total possible score range of 0 to 40.

Jayaram Thimmapuram, Kamlesh D Patel, Deepti Bhatt, Ajay Chauhan, Divya Madhusudhan, Kashyap K Bhatt, Snehal Deshpande, Urvi Budhbhatti, Chaitanya Joshi

JMIR Bioinform Biotech 2024;5:e65506

Internet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth: Pragmatic Randomized Controlled Trial

Internet-Delivered Psychoeducation (SCOPE) for Transition-Aged Autistic Youth: Pragmatic Randomized Controlled Trial

In 2015, Gordon et al [18] conducted a randomized controlled trial (RCT) for autistic adolescents and their parents, with low attrition and high satisfaction among participants. Hidalgo et al [19] conducted an open trial for autistic adults and their close relations using group-based psychoeducational intervention, and Crane et al [20] used autistic-led peer groups; both were able to show low attrition as well as high satisfaction with program contents.

Anna Backman, Lise Roll-Pettersson, Are Mellblom, Elisabet Norman-Claesson, Emma Sundqvist, Eric Zander, Sarah Vigerland, Tatja Hirvikoski

J Med Internet Res 2024;26:e49305

Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Results of a Randomized Controlled Trial

Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Results of a Randomized Controlled Trial

We found 1 randomized study focused on the change in body composition during a weight loss intervention in China [12]. However, the sample size was limited, and the body composition results are not sufficiently accurate considering their measuring method; therefore, we still need more reliable evidence on this topic.

Xi Wang, Suyuan Wang, Lingyu Zhong, Chenghui Zhang, Yanhong Guo, Mingxia Li, Li Zhao, Shuming Ji, Junjie Pan, Yunhong Wu

JMIR Mhealth Uhealth 2024;12:e47104

Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Randomized Controlled Trial

Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Randomized Controlled Trial

This manuscript presents the findings of a randomized controlled trial examining the implementation of internet-based supportive interventions for home care among patients with dementia in China. The trial is an innovative web-based support program that was developed to advance the skills, knowledge, and practice of caregivers, in order to enhance self-care skills in individuals with dementia and simultaneously provide invaluable assistance to their caregivers.

Yanhong Xie, Shanshan Shen, Caixia Liu, Huilan Guan, Jingmei Zhang, Wanqi Yu, Hong Hong

JMIR Aging 2024;7:e50847