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Skip search results from other journals and go to results- 5 JMIR Bioinformatics and Biotechnology
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This is mainly due to the virus’ relatively high mutational rate, with specific mutations occurring on the spike protein affecting its immunogenicity [1,2]. The battle against this virus covers several aspects ranging from prevention, mitigation, and treatment. One promising approach that is still developing with proven efficiency consists of using anti–SARS-Co V-2 monoclonal neutralizing antibodies (NAbs).
JMIR Bioinform Biotech 2024;5:e58018
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The Society for Sarcopenia, Cachexia, and Wasting Disease provided protein recommendations for treating and preventing sarcopenia at a minimum of 1.0 to 1.5 g/kg body weight per day with exercise [22]. The protein quality is also critical in age-related SMM anabolism. Research on how protein-rich whole foods (eg, lean red meat) can enhance MPS over supplementation in older adults is rising [23].
JMIR Form Res 2024;8:e49322
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S100 calcium-binding protein B (S100 B) is a protein that is found in a variety of tissues, including the brain, where it has been implicated in several neurobiological processes, including synaptic plasticity, neurogenesis, and neuroinflammation. High serum S100 B levels have been associated with a variety of neurological disorders, including traumatic brain injury, stroke, and neurodegenerative diseases.
JMIR Res Protoc 2023;12:e50546
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In addition to the S and N proteins, all of these reported Vo Cs comprise the other main structural proteins of SARS-Co V-2, membrane protein (M) and envelope protein (E). Each protein of the virus plays a vital role and also takes part in the replication cycle. The S protein is required for the attachment and amalgamation of the virus to host cell surface receptors, which enables the virus to enter the host cell [19].
JMIR Bioinform Biotech 2023;4:e43906
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To identify and characterize CAF subtypes, a number of markers have been identified, such as desmin, fibroblast activation protein (FAP), fibroblast-specific protein, podoplanin, α-SMA, and vimentin [8,9].
FAP is a type II transmembrane serine protease, which shares a high-sequence identity with dipeptidyl peptidase 4 [10]. In most adult tissues, expression of FAP is low to undetectable. FAP expression becomes highly upregulated in multiple types of cancer, and it is predominantly observed in CAFs [11].
JMIR Res Protoc 2023;12:e45176
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Overall, 6 m L of blood and 5 m L of urine per patient per visit will be used for the analysis of the following 33 biomarkers: inflammatory biomarkers (including macrophage migration inhibitory factor; cytokines IL-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, IL-13, and IL-17α; macrophagic inflammatory protein 1α; TNF-α; vascular cell adhesion molecule 1; intercellular adhesion molecule 1; chemotactic cytokines including monocyte chemoattractant protein 1 and 3 and regulated on activation, normal T-expressed, and
JMIR Res Protoc 2023;12:e38362
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The direct prediction of antibody-antigen interactions from protein sequences remains an open problem.
Machine learning–based tools, such as m CSM-AB [4] and ADAPT (Assisted Design of Antibody and Protein Therapeutics) [5], have had some success in predicting antibody interactions in other contexts. m CSM-AB is a web server for predicting changes in antibody-antigen affinity upon mutation, using graph-based signatures.
JMIR Bioinform Biotech 2022;3(1):e29404
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On the other hand, although total physical activity was associated with breakfast protein intake, it showed the strongest positive relationship with lunch protein intake. Walking had a positive relationship with dinner protein intake.
JMIR Public Health Surveill 2022;8(7):e35898
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The isoelectric point (p I) of a protein is crucial in determining the physicochemical properties of the protein [5]. The exposure of charged amino acids on the protein surface to solvents, hydration, and dehydration also influences the p I of a protein [6,7].
JMIR Bioinform Biotech 2022;3(1):e37391
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They provide high-quality protein, essential fatty acids, and micronutrients that are limited in concentration or bioavailability in exclusively plant-based diets, notably including vitamin B12, iron, zinc, and long-chain omega-3 fatty acids (LCn3) [3]. However, production of meat is resource-intensive and widely censured for its environmental impacts [4]. As a consequence, the trend of meat-rich dietary patterns in Western consumers may not be sustainable.
JMIR Res Protoc 2021;10(12):e30909
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