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Enhancing Adherence and Mental Well-Being in Pediatric Growth Hormone Therapy: Feasibility Prospective Observational Study of a Family-Centered Digital Companion

Enhancing Adherence and Mental Well-Being in Pediatric Growth Hormone Therapy: Feasibility Prospective Observational Study of a Family-Centered Digital Companion

Growth hormone (GH) deficiency (GHD) in the pediatric population causes short stature [1]. Children affected by GHD have also been reported to have worse quality of life, cognitive function, and fatigue than those with normal height [2,3]. Short stature in children is also associated with anxiety, depression, and social withdrawal [4-11].

Antonio de Arriba Muñoz, Amalia M García-Durán, Patricia Sanz-Aznar, Silvia Quer-Palomas, Ioannis Bilionis, Alba Xifra-Porxas, Joia Nuñez, Ricardo C Berrios, Luis Fernández-Luque

JMIR Pediatr Parent 2025;8:e67102


Toward a Clinically Actionable, Electronic Health Record–Based Machine Learning Model to Forecast 90-Day Change in Hemoglobin A1c in Youth With Type 1 Diabetes: Feasibility and Model Development Study

Toward a Clinically Actionable, Electronic Health Record–Based Machine Learning Model to Forecast 90-Day Change in Hemoglobin A1c in Youth With Type 1 Diabetes: Feasibility and Model Development Study

Using data extracted from Oracle Health EHR (formerly Cerner Millenium Electronic Medical Record System; Nashville, Tennessee) [24], we used diagnosis code and laboratory data to identify a cohort of 2757 youth with T1 D who received care from a network of pediatric diabetes clinics in the Midwestern United States between January 2012 and August 2017. Criteria used to identify this T1 D cohort are provided in Multimedia Appendix 1.

Erin M Tallon, David D Williams, Cintya Schweisberger, Colin Mullaney, Brent Lockee, Diana Ferro, Craig A Vandervelden, Mitchell S Barnes, Angelica Cristello Sarteau, Anna R Kahkoska, Susana R Patton, Sanjeev Mehta, Ryan McDonough, Marcus Lind, Leonard D'Avolio, Mark A Clements

JMIR Diabetes 2025;10:e69142


Evaluating Fitbits for Assessment of Physical Activity and Sleep in Pediatric Pain: Feasibility and Acceptability Pilot Study

Evaluating Fitbits for Assessment of Physical Activity and Sleep in Pediatric Pain: Feasibility and Acceptability Pilot Study

Pediatric pain affects nearly 40% of youth globally [1-3] and is associated with significant functional impairment across multiple life domains [4]. Youth who develop a chronic pain disorder are also at increased risk for such disorders persisting into adulthood [5], often resulting in costly health care utilization [6] and positioning pediatric pain as a serious public health concern.

Bridget A Nestor, Andreas M Baumer, Justin Chimoff, Benoit Delecourt, Camila Koike, Nicole Tacugue, Roland Brusseau, Nathalie Roy, Israel A Gaytan-Fuentes, Navil Sethna, Danielle Wallace, Joe Kossowsky

JMIR Form Res 2025;9:e59074


Usefulness of Interventions Using a Smartphone Cognitive Behavior Therapy Application for Children With Mental Health Disorders: Prospective, Single-Arm, Uncontrolled Clinical Trial

Usefulness of Interventions Using a Smartphone Cognitive Behavior Therapy Application for Children With Mental Health Disorders: Prospective, Single-Arm, Uncontrolled Clinical Trial

The prevalence of mental health disorders among children has increased rapidly, and mental health care for children is an increasingly important part of pediatric health care delivery [1,2]. The number of children with school refusal is rapidly rising, and the “hikikomori” (severe social withdrawal) phenomenon may become more common in the postpandemic era [3].

Shinichiro Nagamitsu, Ayumi Okada, Ryoichi Sakuta, Ryuta Ishii, Kenshi Koyanagi, Chizu Habukawa, Takashi Katayama, Masaya Ito, Ayako Kanie, Ryoko Otani, Takeshi Inoue, Tasuku Kitajima, Naoki Matsubara, Chie Tanaka, Chikako Fujii, Yoshie Shigeyasu, Michiko Matsuoka, Tatsuyuki Kakuma, Masaru Horikoshi

JMIR Form Res 2025;9:e60943


Adherence to Therapy Using Neurostimulation Devices in the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: Extraclinical Study

Adherence to Therapy Using Neurostimulation Devices in the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: Extraclinical Study

The emergence of noninvasive neurostimulation technologies for the treatment of ADHD [30,33,42] heralds a new era in therapeutic options for large populations of pediatric patients [32,43].

Allyson Calandro, Saurabh Biswas, Anthony Guiseppi-Elie

JMIR Neurotech 2025;4:e68736


Investigating Challenges in Implementing a Digital Play Intervention in a Complex Organization Across Pediatric Departments: Non-Randomized Controlled Feasibility Trial

Investigating Challenges in Implementing a Digital Play Intervention in a Complex Organization Across Pediatric Departments: Non-Randomized Controlled Feasibility Trial

A recent review of game technologies for pediatric patients showed that the most common approach is mono-user games on ordinary computers or video consoles, for example, Play Station and Nintendo Wii, that often serve to distract children undergoing procedures such as venipuncture or who experience chronic, neurological, or traumatic diseases or injuries [1].

Laerke Winther, Michelle Stahlhut, Derek John Curtis, Christian Have Dall, Thomas Leth Frandsen, Jette Led Sorensen

JMIR Rehabil Assist Technol 2025;12:e58019


Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

The most frequently used CPSs in children are the Alvarado score [2], the Pediatric Appendicitis Score (PAS) [3], and the pediatric appendicitis risk calculator (p ARC) [4], with each based on different sets of collected variables. The Alvarado score is one of the most widely studied CPSs for the diagnosis of acute appendicitis in adult populations based on 8 variables with a total score of 10 [2], and it has since been studied in pediatric populations with varying results [33-44].

Wei Hao Lee, Sharon O'Brien, Elizabeth J Mckinnon, Simon Craig, Stuart Dalziel, Michael Collin, Natalie Phillips, Franz E Babl, Sarah Julia Davidson, Shane George, Shefali Jani, Doris Tham, Viet Tran, Meredith L Borland

JMIR Res Protoc 2025;14:e67941