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Detecting Freezing of Gait in Parkinson Disease Using Multiple Wearable Sensors Sets During Various Walking Tasks Relative to Medication Conditions (DetectFoG): Protocol for a Prospective Cohort Study

Detecting Freezing of Gait in Parkinson Disease Using Multiple Wearable Sensors Sets During Various Walking Tasks Relative to Medication Conditions (DetectFoG): Protocol for a Prospective Cohort Study

Affecting more than 8.5 million people worldwide in 2019, Parkinson disease (PD) is the second most common neurodegenerative disease [1]. PD is diagnosed using criteria from the UK Parkinson’s Disease Society Brain Bank [2] and is defined by the cardinal symptoms of tremor, bradykinesia, rigidity, and postural instability, along with other motor and nonmotor symptoms [3].

Sébastien Cordillet, Sophie Drapier, Frédérique Leh, Audeline Dumont, Florian Bidet, Isabelle Bonan, Karim Jamal

JMIR Res Protoc 2025;14:e58612

A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study

A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study

Neurodegenerative conditions such as Alzheimer disease (AD) and related dementias precipitate accelerated cognitive deterioration, markedly impacting patients’ daily lives and social engagement [1]. Current estimates suggest that approximately 50 million individuals worldwide suffer from dementia, with this number expected to soar to 152 million by 2050 [2]. Generally, patients diagnosed with mild cognitive impairment (MCI) are at a much higher risk of developing dementia [3].

Aoyu Li, Jingwen Li, Yishan Hu, Yan Geng, Yan Qiang, Juanjuan Zhao

JMIR Med Inform 2025;13:e60250

Impact of Weekly Community-Based Dance Training Over 8 Months on Depression and Blood Oxygen Level–Dependent Signals in the Subcallosal Cingulate Gyrus for People With Parkinson Disease: Observational Study

Impact of Weekly Community-Based Dance Training Over 8 Months on Depression and Blood Oxygen Level–Dependent Signals in the Subcallosal Cingulate Gyrus for People With Parkinson Disease: Observational Study

Depression affects 280 million people globally and is considered a prodromal feature for increasingly prevalent neurodegenerative conditions, including Parkinson disease (PD). More than 10 million people live with PD, the fastest growing neurological disorder worldwide [1]. Most commonly reported PD symptoms pertain to motor and nonmotor symptoms (NMSs), such as anxiety, depression, fatigue, apathy, cognitive disturbances, and dementia [2-4], significantly impacting health and quality of life (Qo L).

Karolina A Bearss, Rebecca E Barnstaple, Rachel J Bar, Joseph F X DeSouza

JMIRx Med 2024;5:e44426

Markerless Motion Capture to Quantify Functional Performance in Neurodegeneration: Systematic Review

Markerless Motion Capture to Quantify Functional Performance in Neurodegeneration: Systematic Review

MMC is attractive for health care and research use, such as monitoring functional performance loss or improvement in neurodegenerative diseases. While traditional movement analyses are based on subjective clinical assessments, MMC can be used to generate objective and quantifiable digital biomarkers that can help detect a decline in functional performance by capturing movement unobtrusively [9]. Variations in these digital biomarkers could indicate underlying impairment and enable earlier support.

Julian Jeyasingh-Jacob, Mark Crook-Rumsey, Harshvi Shah, Theresita Joseph, Subati Abulikemu, Sarah Daniels, David J Sharp, Shlomi Haar

JMIR Aging 2024;7:e52582

Web Application to Enable Online Social Interactions in a Parkinson Disease Risk Cohort: Feasibility Study and Social Network Analysis

Web Application to Enable Online Social Interactions in a Parkinson Disease Risk Cohort: Feasibility Study and Social Network Analysis

Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer disease [1]. It is associated with disability, loss of independence, caregiver burden, and premature death [2]. Life expectancy is reduced for all patients, especially in individuals with early-onset PD [2]. More than 75% have dementia after 8 years from diagnosis [3]. PD onset age is typically 60-65 years [4], with early onset being considered between 21 and 50 years [5].

Xiancheng Li, Aneet Gill, Pietro Panzarasa, Jonathan Bestwick, Anette Schrag, Alastair Noyce, Anna De Simoni

JMIR Form Res 2024;8:e51977

Personalized Integrated Care Promoting Quality of Life for Older People: Protocol for a Multicenter Randomized Controlled Trial

Personalized Integrated Care Promoting Quality of Life for Older People: Protocol for a Multicenter Randomized Controlled Trial

The aging of the population, accompanied by an increase in chronic diseases, including cardiovascular diseases, diabetes, asthma, mental and physical disorders, and neurodegenerative conditions, represents the main cause of this situation [2,3]. In fact, the existence of comorbidities and the confluence of several chronic diseases are progressively more frequent in older adults, which increases the need to develop models and tools to improve integrated health care systems.

Elda Judica, Peppino Tropea, Raquel Bouça-Machado, Mayca Marín, Elisa Calarota, Liviu Cozma, Raluca Badea, Mona Ahmed, Michael Brach, Joaquim J Ferreira, Massimo Corbo

JMIR Res Protoc 2023;12:e47916