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Impact of 12-Month mHealth Home Telemonitoring on Clinical Outcomes in Older Individuals With Hypertension and Type 2 Diabetes: Multicenter Randomized Controlled Trial

Impact of 12-Month mHealth Home Telemonitoring on Clinical Outcomes in Older Individuals With Hypertension and Type 2 Diabetes: Multicenter Randomized Controlled Trial

Older people face challenges such as multimorbidity, cognitive impairment, visual impairment, limited mobility, environmental dependency, and reluctance to adopt modern technologies, which may reduce its effectiveness [2,5,23,24]. Considering demographic shifts, it is imperative to evaluate the benefits of telemonitoring in this age group and to adapt interventions to address the specific needs of older people.

Matic Mihevc, Majda Mori Lukančič, Črt Zavrnik, Tina Virtič Potočnik, Nina Ružić Gorenjec, Marija Petek Šter, Zalika Klemenc-Ketiš, Antonija Poplas Susič

JMIR Mhealth Uhealth 2025;13:e59733

Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models

Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models

Research on chronic multimorbidity has increasingly become a focal point with the aging of the population [1]. Major research directions include exploring multimorbidity patterns [2,3], investigating multimorbidity development and prediction [4,5], and examining the mutual interplay between multimorbidity and patient characteristics [6]. Amid ongoing research on frequently occurring diseases, extracting patient characteristics holds paramount importance.

Junyan Zhang, Junchen Zhou, Liqin Zhou, Zhichao Ba

JMIR Med Inform 2025;13:e70096

Co-Occurring Diseases and Mortality in Patients With Chronic Heart Disease, Modeling Their Dynamically Expanding Disease Portfolios: Nationwide Register Study

Co-Occurring Diseases and Mortality in Patients With Chronic Heart Disease, Modeling Their Dynamically Expanding Disease Portfolios: Nationwide Register Study

The studies that consider multimorbidity either restrict their analyses to a subset of diagnosis combinations [7] or group diagnoses into multimorbidity clusters at baseline before analyzing the effects of the extracted clusters [5]. Despite modeling disease interactions, these kinds of analyses fail to capture the crucial dynamics in the HD disease trajectories, where additional diseases are cumulatively diagnosed before death [10], causing an augmented risk profile for the patient.

Nikolaj Normann Holm, Anne Frølich, Helena Dominguez, Kim Peder Dalhoff, Helle Gybel Juul-Larsen, Ove Andersen, Anders Stockmarr

JMIR Cardio 2025;9:e57749

Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial

Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial

Despite the high prevalence of multimorbidity worldwide, with its consequent demand for care and important health and economic consequences [18], much work remains to be done. Multimorbidity interventions pose a challenge for present-day health care systems [19]. As pointed out by a previous meta-analysis, it is difficult to improve outcomes in people with multimorbidity, although interventions oriented toward depression or specific difficulties and risk factors are promising [17].

Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

J Med Internet Res 2025;27:e56203

Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review

Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review

The aging world population and an increased prevalence of chronic conditions and multimorbidity have placed greater pressure on health care systems and professionals [1]. In Europe, over 50 million people have at least 1 chronic disease [2]; and in the United States, it is estimated that the number of people aged 50 years and older with at least 1 chronic disease will increase by 100%, from 71 million in 2020 to 142 million by 2050 [3].

Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

J Med Internet Res 2025;27:e54470

A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study

A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study

Multimorbidity is the presence of 2 or more long-term health conditions in a person [1]. Typically, multimorbidity was considered a problem for older populations but is increasingly recognized as a challenge in younger people as well [2]. Multimorbidity is associated with worse physical and mental health function, higher service use, and higher mortality [3-5].

Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

J Med Internet Res 2025;27:e52385

Creating a Modified Version of the Cambridge Multimorbidity Score to Predict Mortality in People Older Than 16 Years: Model Development and Validation

Creating a Modified Version of the Cambridge Multimorbidity Score to Predict Mortality in People Older Than 16 Years: Model Development and Validation

People with multimorbidity, defined by those with 2 or more long-term conditions (LTCs) [1-6], have complex needs and impose increasing demands on primary care services given the aging population. Multimorbidity is associated with reduced life expectancy [7], lower quality of life [8], and an increased risk of hospitalization and death due to COVID-19 [9]. In clinical trials, vaccination against COVID-19 showed reduced risk of hospitalization and death in all groups [10,11].

Debasish Kar, Kathryn S Taylor, Mark Joy, Sudhir Venkatesan, Wilhelmine Meeraus, Sylvia Taylor, Sneha N Anand, Filipa Ferreira, Gavin Jamie, Xuejuan Fan, Simon de Lusignan

J Med Internet Res 2024;26:e56042