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Adaptation of an mHealth Solution for the Nutritional Management of Diabetes in a Low- and Middle-Income Country: Pre-Post Mixed Methods Pilot Study

Adaptation of an mHealth Solution for the Nutritional Management of Diabetes in a Low- and Middle-Income Country: Pre-Post Mixed Methods Pilot Study

CC, in conjunction with insulin dosage adjustments, plays a pivotal role in the effective management of T1 DM, improving metabolic control and enhancing the quality of life [5]. CC involves a dietary management strategy that quantifies the carbohydrate content of food, enabling individuals to administer the appropriate insulin dose to maintain optimal blood glucose levels [6]. The use of technology has proven effective in enhancing CC education and the overall learning experience [7,8].

Cecilia Anza-Ramirez, Karen Bonilla-Aguilar, David Beran, Jean-Luc Mando, Lorena Saavedra-Garcia, Monica Julissa Angulo-Barranca, Marco Alexi Taboada Garcia, Leonardo Albitres-Flores, Alejandro Loayza, Jessica Hanae Zafra-Tanaka, Olivia Heller, María Lazo-Porras, Montserrat Castellsague Pique Perolini

JMIR Mhealth Uhealth 2025;13:e58029


Digital Innovation and Integrated Care in People With Diabetes in Western Sydney: Retrospective Cohort Study

Digital Innovation and Integrated Care in People With Diabetes in Western Sydney: Retrospective Cohort Study

Specifically, we extracted hemoglobin A1c (Hb A1c), total daily dose of insulin, and CGM metrics including time in range, glucose management indicator, and time above and below range. In addition, we collected detailed information about medication usage. A convenience sampling method was used, culminating in the collection of 103 patient records. Data were securely stored in a dedicated database for analysis. We did not have specific inclusion or exclusion criteria beyond the sampling methodology.

Ummul Mahfuza, Gideon Meyerowitz-Katz, Riham Abdulla Rasheed, Helen Dick, Glen Maberly, Rajini Jayaballa

JMIR Diabetes 2025;10:e64832


Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

These signals include ghrelin, cholecystokinin, insulin, glucose-dependent insulinotropic polypeptide, secretin, peptide tyrosine tyrosine, insulin-like peptide 5, neurotensin, substance P, and GLP-1. The hormones relay information to the brain about acute changes in energy needs via stimulation of the vagus nerve, with some signals crossing the blood-brain barrier to bind to receptors in neural circuits that impact feeding [25].

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554


High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial

High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial

Each prediabetes phenotype exhibits distinct pathophysiological abnormalities [5-7]. i-IFG is marked by impaired early-phase insulin secretion and hepatic insulin resistance. Conversely, i-IGT involves impairments in both early- and late-phase insulin secretion and skeletal muscle insulin resistance [5,7].

Sathish Thirunavukkarasu, Thomas R Ziegler, Mary Beth Weber, Lisa Staimez, Felipe Lobelo, Mindy L Millard-Stafford, Michael D Schmidt, Aravind Venkatachalam, Ram Bajpai, Farah El Fil, Maria Prokou, Siya Kumar, Robyn J Tapp, Jonathan E Shaw, Francisco J Pasquel, Joe R Nocera

JMIR Res Protoc 2025;14:e59842


Web-Based, Algorithm-Guided Insulin Titration in Insulin-Treated Type 2 Diabetes: Pre-Post Intervention Study

Web-Based, Algorithm-Guided Insulin Titration in Insulin-Treated Type 2 Diabetes: Pre-Post Intervention Study

In an earlier study, we demonstrated the ability of a web-based blood glucose monitoring system to optimize insulin dosages for patients receiving a basal-plus or basal-bolus insulin regimen. Importantly, glycemic control improved without increasing hypoglycemia rates [18]. However, although this approach reduced the need for face-to-face visits for insulin titration, physicians still need to review a large amount of SMBG data before recommending any insulin dose adjustment.

Nishanth Thiagarajan, Hong Chang Tan, Suresh Rama Chandran, Phong Ching Lee, Yun Ann Chin, Wanling Zeng, Emily Tse Lin Ho, David Carmody, Su-Yen Goh, Yong Mong Bee

JMIR Form Res 2025;9:e68914


Comparing Insulin Against Glucagon-Like Peptide-1 Receptor Agonists, Dipeptidyl Peptidase-4 Inhibitors, and Sodium-Glucose Cotransporter 2 Inhibitors on 5-Year Incident Heart Failure Risk for Patients With Type 2 Diabetes Mellitus: Real-World Evidence Study Using Insurance Claims

Comparing Insulin Against Glucagon-Like Peptide-1 Receptor Agonists, Dipeptidyl Peptidase-4 Inhibitors, and Sodium-Glucose Cotransporter 2 Inhibitors on 5-Year Incident Heart Failure Risk for Patients With Type 2 Diabetes Mellitus: Real-World Evidence Study Using Insurance Claims

Several other large observational studies reported the association of insulin with increased risk of CVD-related outcomes, including comparisons across doses of insulin, of insulin monotherapy versus insulin plus metformin, and of insulin versus novel therapies (DPP-4 Is or SGLT2 Is grouped together) [8]. These studies did not cover all head-to-head comparisons between insulin and alternative therapies.

Xuan Wang, Anna M Plantinga, Xin Xiong, Sara J Cromer, Clara-Lea Bonzel, Vidul Panickan, Rui Duan, Jue Hou, Tianxi Cai

JMIR Diabetes 2024;9:e58137


A Serious Game (MyDiabetic) to Support Children’s Education in Type 1 Diabetes Mellitus: Iterative Participatory Co-Design and Feasibility Study

A Serious Game (MyDiabetic) to Support Children’s Education in Type 1 Diabetes Mellitus: Iterative Participatory Co-Design and Feasibility Study

Nutritional education, with systematic assessments of carbohydrate intake and the use of the insulin-to-carbohydrate ratio, has allowed for optimizing insulin dosage [2]. The basal-bolus scheme with multiple-dose insulin injections, continuous subcutaneous insulin infusion, and multiple capillary blood glucose measurements allow for better metabolic control. For this, adequate and continued diabetes education for patients and families is required [3].

Daniel Novak

JMIR Serious Games 2024;12:e49478


Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial

Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial

These actions result in increased vascular blood flow and shear stress via gravitational pull and the skeletal muscle pump, thus increasing venous return, decreasing blood pooling in the lower limbs, and activating contraction- and insulin-mediated glucose uptake pathways [21].

Shannon L Wilson, Rachel Crosley-Lyons, Jordan Junk, Kristina Hasanaj, Miranda L Larouche, Kevin Hollingshead, Haiwei Gu, Corrie Whisner, Dorothy D Sears, Matthew P Buman

JMIR Res Protoc 2023;12:e45133