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CoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study

CoVimmune COVID-19 Immunity Calculator: Web Application Development and Validation Study

Co Vimmune COVID-19 immunity calculator website interface for the application. GFR: glomerular filtration rate; IC50: half-maximal inhibitory concentration; Ig G: immunoglobulin G. Co Vimmune COVID-19 immunity calculator results with an example input. BAU: binding antibody unit; IC50: half-maximal inhibitory concentration; Ig G: immunoglobulin G.

Rebecca Slotkin, Tassos C Kyriakides, Vinni Yu, Xien Chen, Anupam Kundu, Shaili Gupta

JMIR Form Res 2025;9:e59467

Effectiveness of Chinese Herbal Medicine as a Complementary Treatment for Neutropenia Prevention and Immunity Modulation During Chemotherapy in Patients With Breast Cancer: Protocol for a Real-World Pragmatic Clinical Trial

Effectiveness of Chinese Herbal Medicine as a Complementary Treatment for Neutropenia Prevention and Immunity Modulation During Chemotherapy in Patients With Breast Cancer: Protocol for a Real-World Pragmatic Clinical Trial

Moreover, higher pre-NAC s TILs and elevated pre-NAC expression of cytotoxic T-cell markers and cytokines are associated with better pathological complete response and overall survival rates [5]. s TILs, with a published cutoff of 30%, are the most widely studied marker of antitumor immunity. Besides, these s TILs could be used to predict improved response to NAC and better prognosis in the context of residual disease of patients lacking pathologic complete response.

Kai-Hung Wang, Hsuan-Shu Shen, Sung-Chao Chu, Tso-Fu Wang, Ching-Wei Lin, Wei-Han Huang, Yi-Feng Wu, Ching-Chun Ho, Cheng-Yoong Pang, Chi-Cheng Li

JMIR Res Protoc 2024;13:e55662

Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study

Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study

Substantial differences were reported in the effectiveness and duration of natural versus vaccine-conferred or hybrid immunity against SARS-Co V-2 reinfection [4,5]. In particular, prior infection after 1 dose of vaccine elicited antispike Ig G antibody responses with higher peak levels or longer half-lives than 1 or 2 vaccinations in seronegative individuals [6].

Stéphanie Bougeard, Adeline Huneau-Salaun, Mikael Attia, Jean-Baptiste Richard, Caroline Demeret, Johnny Platon, Virginie Allain, Stéphane Le Vu, Sophie Goyard, Véronique Gillon, Sibylle Bernard-Stoecklin, Bernadette Crescenzo-Chaigne, Gabrielle Jones, Nicolas Rose, Sylvie van der Werf, Olivier Lantz, Thierry Rose, Harold Noël

JMIR Public Health Surveill 2023;9:e46898

Fight Against the Mandatory COVID-19 Immunity Passport on Twitter: Natural Language Processing Study

Fight Against the Mandatory COVID-19 Immunity Passport on Twitter: Natural Language Processing Study

To contain and curb the spread of COVID-19, the governments of countries around the world used different strategies, such as lockdown, mandatory vaccination, immunity passports, voluntary social distancing, mask mandates, minimal room crowding, contact restrictions, and hygiene measures [2-7]. These obligations posed ethical questions [8] and generated a dynamic of change in people’s choices and behaviors regarding vaccination and various restrictive measures [9].

Jessica S M Gable, Romy Sauvayre, Cédric Chauvière

J Med Internet Res 2023;25:e49435

Investigating the Role of Nutrition in Enhancing Immunity During the COVID-19 Pandemic: Twitter Text-Mining Analysis

Investigating the Role of Nutrition in Enhancing Immunity During the COVID-19 Pandemic: Twitter Text-Mining Analysis

Based on our analysis, supplements are the most commonly referenced topic among Twitter users, with over 33.6% (23,913/71,178) of tweets mentioning them as a way to improve immunity. Intake of fluids was mentioned in nearly 24.85% (17,685/71,178) of the tweets, while 20.80% (14,807/71,178) of the tweets referenced fruits as a way to boost immunity against the novel coronavirus. Spices and herbs were mentioned in 12.25% (8719/71,178) of the tweets, and vegetables were referenced in 10.47% of the tweets.

Kavitha Shankar, Ranganathan Chandrasekaran, Pruthvinath Jeripity Venkata, Derek Miketinas

J Med Internet Res 2023;25:e47328

The Effects of HIV Infection on the Immune Response to Malaria Among Pregnant Women in Kumba, Southwest Cameroon: Protocol for a Cross-sectional Study

The Effects of HIV Infection on the Immune Response to Malaria Among Pregnant Women in Kumba, Southwest Cameroon: Protocol for a Cross-sectional Study

Epidemiological studies suggest that pregnant women with HIV have a considerable decrease in the acquired immunity to malaria, resulting in a diminished ability to limit P. falciparum infection. This finding is corroborated by the fact that sulfadoxine-pyrimethamine–intermittent preventive treatment's (SP-IPT) effectiveness in pregnant women with HIV reduces [7,8]. Prior studies have shown that HIV infection interferes with the breadth of the antibody response to merozoite surface protein (MSP) antigens.

Bekindaka Ngemani Obase, Zeukeng Francis, Esemu Livo Forgu, Awanakam Honore, Jude Daiga Bigoga, Dickson S Nsagha

JMIR Res Protoc 2023;12:e38213

COVID-19 and Vitamin D Misinformation on YouTube: Content Analysis

COVID-19 and Vitamin D Misinformation on YouTube: Content Analysis

Overall, the suggestion of vitamin D supplements being a safe and easy way to “boost immunity” was a common thread in many videos. Videos commonly discussed the general function of vitamin D (55/77, 71%) and how vitamin D functions in overall immunity (62/77, 80%). Many videos highlighted that vitamin D is known as the “sunshine vitamin” and stated that a considerable proportion of the global population is vitamin D insufficient or deficient.

Emma K Quinn, Shelby Fenton, Chelsea A Ford-Sahibzada, Andrew Harper, Alessandro R Marcon, Timothy Caulfield, Sajjad S Fazel, Cheryl E Peters

JMIR Infodemiology 2022;2(1):e32452

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Monocytes and natural killer (NK) cells were believed to play key roles in triggering such trained immunity in murine studies [5]. In addition, the enhancement of monocyte and NK cell responses following BCG vaccination has been reported in humans, and this is due to epigenetic modification at the H3 K4me3 (trimethylation of lysine 4 on histone H3) level [6].

Giuseppe Ietto, Lorenzo Mortara, Daniela Dalla Gasperina, Domenico Iovino, Lorenzo Azzi, Andreina Baj, Walter Ageno, Angelo Paolo Genoni, Francesco Acquati, Matteo Gallazzi, Giorgia Spina, Grace Coco, Federica Pierin, Douglas Noonan, Andrea Vigezzi, Elisa Monti, Valentina Iori, Federica Masci, Caterina Franchi, Salomone Di Saverio, Giulio Carcano

JMIR Res Protoc 2022;11(1):e29892