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Skip search results from other journals and go to results- 3 JMIR Research Protocols
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Treatment with hydroxyurea increases fetal hemoglobin and has other salutary benefits (eg, reduced inflammation) that together function as protection against organ damage and VOCs and increase the rate of patient survival [3]. Despite the proven efficacy and effectiveness of hydroxyurea as a prophylactic treatment in SCD, it is vastly underutilized, a result of a combination of poor prescribing practices among providers and low adherence behavior among patients [4].
JMIR Form Res 2024;8:e48767
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Hydroxyurea use and barriers: patients completed a 7-item study-specific survey assessing hydroxyurea use (eg, current and past use, if any, and duration if currently using hydroxyurea) and perceived barriers to hydroxyurea use.
Health literacy: patients completed the Newest Vital Sign (NVS) [66], a 6-item validated screening tool that assesses an individual’s ability to understand and apply information displayed on a nutrition label for ice cream. This tool measures both health literacy and numeracy.
JMIR Mhealth Uhealth 2020;8(5):e14884
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For example, in the context of the HBM, hydroxyurea nonadherence could occur if patients and/or their families do not perceive the long-term health benefits of taking hydroxyurea outweigh the potential risk of experiencing side effects or the length of time that they must take hydroxyurea before its benefits begin to manifest.
JMIR Mhealth Uhealth 2019;7(8):e13452
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The early identification of children with elevated TCD velocities, identification of variables that may predict stroke risk, and early intervention with hydroxyurea would therefore have significant public health implications. Hydroxyurea is available, but not utilized by most patients with SCA. The current clinical practice in the Dominican Republic is to offer hydroxyurea at around 15 mg/kg/day to families who can afford the daily medication, which costs US $1 per capsule.
JMIR Res Protoc 2017;6(6):e107
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Hydroxyurea (HU) is the only disease-modifying medication for patients with SCD. HU is a once-daily medication taken by mouth that comes in a capsule or liquid formulation and clinical trials indicate that HU reduces the frequency of vaso-occlusive pain and acute chest syndrome episodes, mortality, and health care costs for pediatric patients [5-8].
JMIR Res Protoc 2016;5(4):e193
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Hydroxyurea is thought to prevent vaso-occlusive crises and pain episodes in children with SCA in part through generation of NO [19,27,28]. Through this mechanism, hydroxyurea could actually lead to protection from malaria.
JMIR Res Protoc 2016;5(2):e110
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