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Peer Review for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

Peer Review for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

This is the peer-review report for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-Co V-2 Infections: Ambispective Observational Study.” This paper [1] looks appropriate and relevant. Some corrections are needed. Additionally, none of the figures (except x-rays and study workflow) are properly visible on the PDF or Word version, so I cannot comment on their content. Please provide better-quality pictures, if possible.

Petar Velikov

JMIRx Med 2024;5:e60168

Peer Review for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

Peer Review for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

This is the peer-review report for “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-Co V-2 Infections: Ambispective Observational Study.” COVID-19–associated hepatitis in children (CAH-C) during the second wave of SARS-Co V-2 infections in Central India: is it a complication or transient phenomenon? The topics of this paper [1] are interesting but the results are not clear and robust.

Mario Coccia

JMIRx Med 2024;5:e59596

Authors’ Response to Peer Reviews of “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

Authors’ Response to Peer Reviews of “Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study”

In this scenario our study identified 37 cases with a unique presentation of acute hepatitis designated as CAH-C, whereas MIS-C could account for hepatitis in 10 cases amongst 15873 children screened in the district during the study period.” The number 15,873 in the Results section was previously mentioned as all screened patients regardless of age, and only 475 (2.99%) were actually children. Please correct or elaborate. Response: Thank you for pointing out this discrepancy.

Sumit Kumar Rawat, Ajit Anand Asati, Nitu Mishra, Ashish Jain, Radha Kanta Ratho

JMIRx Med 2024;5:e59327

Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study

Identification of COVID-19–Associated Hepatitis in Children as an Emerging Complication in the Wake of SARS-CoV-2 Infections: Ambispective Observational Study

During the ongoing phase of the pandemic, apart from children with MIS-C, there was another group of children presenting with hepatitis. This unique presentation of hepatitis was temporally associated with SARS-Co V-2 infections, which is designated by us as COVID-19–associated hepatitis in children (CAH-C). Such hepatitis cases outnumbered MIS-C cases and lacked the hallmarks of inflammation seen in MIS-C.

Sumit Kumar Rawat, Ajit Anand Asati, Nitu Mishra, Ashish Jain, Radha Kanta Ratho

JMIRx Med 2024;5:e48629

Care Integration for Hepatitis C Virus Treatment Through Facilitated Telemedicine Within Opioid Treatment Programs: Qualitative Study

Care Integration for Hepatitis C Virus Treatment Through Facilitated Telemedicine Within Opioid Treatment Programs: Qualitative Study

Additionally, people with OUD have high hepatitis C virus (HCV) incidence and prevalence due to injection drug use and limited access to HCV therapy [3]. To achieve HCV elimination by 2030, as proposed in several jurisdictions [4-6], HCV treatment access must increase. We sought to address restricted HCV care access for people with OUD through a randomized controlled trial of care integration using technology that is at the intersection of the internet or videoconferencing, and health care.

Suzanne S Dickerson, Saliyah J George, Ana Ventuneac, Arpan Dharia, Andrew H Talal

J Med Internet Res 2024;26:e53049

Hepatitis C Knowledge and Self-Reported Testing Behavior in the General Population in China: Online Cross-Sectional Survey

Hepatitis C Knowledge and Self-Reported Testing Behavior in the General Population in China: Online Cross-Sectional Survey

Initially, awareness of HCV was determined based on participant responses to the following question: “Have you ever heard of hepatitis C disease or hepatitis C virus (HCV)?” Individuals who replied yes were considered as being aware of HCV and asked additional questions to assess the depth of their HCV knowledge based on surveys conducted previously [18,19].

Yin Liu, Juan Su, Xiaoyang Wang, Huifang Xu, Hong Wang, Ruihua Kang, Liyang Zheng, Yixian Wang, Chunya Liu, Yiping Jing, Shaokai Zhang

JMIR Public Health Surveill 2023;9:e39472

Fostering Patient-Clinician Communication to Promote Rapid HIV, Hepatitis B Virus, and Hepatitis C Virus Diagnostic Testing: Conceptual Development of a Multilingual App

Fostering Patient-Clinician Communication to Promote Rapid HIV, Hepatitis B Virus, and Hepatitis C Virus Diagnostic Testing: Conceptual Development of a Multilingual App

Migrants are disproportionately affected by HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). A meta-analysis comparing migrants with native-born populations found that migrants have a high HIV prevalence ratio [1]. A recent French study found that among migrants living with HIV, HBV, or HCV, 56%, 71%, and 89% were respectively diagnosed in France [2], whereas another study reported that 57% of migrants who are HIV positive acquired the virus while in the country [3].

Carter Brown, Guillaume Roucoux, Olivia Rousset-Torrente, Saleh Ali, Lisa Yombo-Kokule, John Chaplin, Olivier Chassany, Martin Duracinsky

JMIR Form Res 2023;7:e49251

Hepatitis A Vaccination Coverage Among People With Chronic Liver Disease in England (HEALD): Protocol for a Retrospective Cohort Study

Hepatitis A Vaccination Coverage Among People With Chronic Liver Disease in England (HEALD): Protocol for a Retrospective Cohort Study

Hepatitis A (Hep A) is a viral infection of the liver caused by the hepatitis A virus (HAV). HAV is transmitted through the fecal-oral route, mainly by exposure to contaminated water sources. Hep A outbreaks are uncommon in the United Kingdom, and most people manifest mild to moderate symptoms that tend to resolve, without sequelae, within several months.

Bernardo Meza-Torres, Anna Forbes, William Elson, Debasish Kar, Gavin Jamie, William Hinton, Xuejuan Fan, Rachel Byford, Michael Feher, Martin Whyte, Mark Joy, Simon de Lusignan

JMIR Res Protoc 2023;12:e51861

Testing for Hepatitis C During Pregnancy Among Persons With Medicaid and Commercial Insurance: Cohort Study

Testing for Hepatitis C During Pregnancy Among Persons With Medicaid and Commercial Insurance: Cohort Study

In 2020, the USPSTF and CDC recommended that all pregnant persons be screened during each pregnancy for hepatitis C [14]. However, there are limited data on trends in hepatitis C testing during pregnancy. We estimated hepatitis C testing rates in a large cohort of patients with Medicaid and commercial insurance who gave birth during 2015-2019 and described demographic and risk-based factors associated with testing.

Mohammed A Khan, William W Thompson, Ademola Osinubi, William A Meyer 3rd, Harvey W Kaufman, Paige A Armstrong, Monique A Foster, Noele P Nelson, Carolyn Wester

JMIR Public Health Surveill 2023;9:e40783

The Fatty Liver, Cirrhosis, and Liver Cancer Study (TENDENCY): Protocol for a Multicenter Case-Control Study

The Fatty Liver, Cirrhosis, and Liver Cancer Study (TENDENCY): Protocol for a Multicenter Case-Control Study

Cirrhosis can be caused by chronic viral hepatitis (B and C), chronic alcohol abuse, inherited metabolic diseases such as genetic haemochromatosis, or in some cases alpha-1-antitrypsin deficiency. The acquired metabolic disorder, nonalcoholic fatty liver disease (NAFLD), has also emerged as an important risk factor. NAFLD is a manifestation of the metabolic syndrome and is associated with type 2 diabetes mellitus and obesity. NAFLD affects around 20% to 30% of the adult population.

Yaqza Hussain, Ayman Bannaga, Neil Fisher, Ashwin Krishnamoorthy, Peter Kimani, Ahmad Malik, Maria Truslove, Shivam Joshi, Megan Hitchins, Abdullah Abbasi, Christopher Corbett, Matthew Brookes, Harpal Randeva, Nwe Ni Than, Ramesh P Arasaradnam

JMIR Res Protoc 2023;12:e44264