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Deprescribing is an established management strategy to minimize polypharmacy and PIMs. It is, in general, a safe process, with a minor risk of causing withdrawal symptoms or return of the condition that was being treated [18,20]. Deprescribing is proven effective, leading to less treatment burden, reduced side effects, and lower medication expenses. However, there is less evidence on the impact of deprescribing on clinical and patient-centered outcomes [21].
JMIR Res Protoc 2024;13:e56277
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In response to these challenges, deprescribing has emerged as a crucial strategy. Deprescribing is defined as “the process of identifying and discontinuing medications in which existing or potential harms outweigh potential benefits within the context of an individual patient’s care goals, function, values, and preferences” [5].
JMIR Res Protoc 2024;13:e55638
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Two key challenges to deprescribing sedative-hypnotics are rebound insomnia symptoms and the lack of personalized care (eg, educational brochures) [49]. Many individuals report being unaware of the risks associated with sedative-hypnotics, thus education and multidisciplinary collaboration are critical, especially as these factors are associated with enhanced deprescribing outcomes [50].
JMIR Res Protoc 2023;12:e47636
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In preparation for this trial, we noticed a gap in the literature regarding the implementation of blended care for deprescribing in a primary care setting. Thus, a multicomponent process evaluation was set up to increase our understanding of this complex intervention. We report on both the setup and results of this process evaluation to inform future implementation projects on blended care in general practice.
JMIR Form Res 2023;7:e43738
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Conceptual context–mechanism–outcome framework for antidepressant deprescribing. AD: antidepressant; GP: general practitioner.
JMIR Res Protoc 2022;11(12):e42526
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As for the deprescribing of chronic diuretics, 1 study reported preserved health outcomes after deprescribing [25], but 2 others failed to do so [26,27]. A 2016 review by Page et al [28] aimed to determine if deprescribing is a safe, effective, and feasible intervention to reduce mortality in older adults.
JMIR Res Protoc 2021;10(12):e25200
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