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Reactivity to Smoking Cues in a Social Context: Virtual Reality Experiment

Reactivity to Smoking Cues in a Social Context: Virtual Reality Experiment

One of the diagnostic criteria for tobacco use disorder is craving [2], which describes the strong urge or desire to smoke. Craving is a well-established driver of smoking behavior [3,4] and relapse after smoking cessation [5]. A meta-analysis on cue-reactivity in smokers shows that the presentation of smoking-related cues can induce craving for cigarettes and that self-reported craving is a valuable index for cue-reactivity, as effect sizes were robust across different moderators.

Katharina Eidenmueller, Sabine Hoffmann, Kornelius Kammler-Sücker, Leonard Wenger, Massimiliano Mazza, Christiane Mühle, Manuel Stenger, Gerrit Meixner, Falk Kiefer, Bernd Lenz

JMIR Form Res 2025;9:e71285

Proximal Effects of a Just-in-Time Adaptive Intervention for Smoking Cessation With Wearable Sensors: Microrandomized Trial

Proximal Effects of a Just-in-Time Adaptive Intervention for Smoking Cessation With Wearable Sensors: Microrandomized Trial

For instance, Craving to Quit, a module-based mindfulness smartphone app, showed promise, although there were no significant differences between craving to quit and the comparison condition (inactive attention control) on biochemically-verified abstinence at 6 months (9.8% vs 12.1%) [15].

Christine Vinci, Steve K Sutton, Min-Jeong Yang, Sarah R Jones, Santosh Kumar, David W Wetter

JMIR Mhealth Uhealth 2025;13:e55379

Real-Time fMRI Neurofeedback Modulation of Dopaminergic Midbrain Activity in Young Adults With Elevated Internet Gaming Disorder Risk: Randomized Controlled Trial

Real-Time fMRI Neurofeedback Modulation of Dopaminergic Midbrain Activity in Young Adults With Elevated Internet Gaming Disorder Risk: Randomized Controlled Trial

In a larger study (N=20), we evaluated whether 2 neurofeedback training sessions for VTA downregulation reduced craving for internet gaming. We recruited young participants with IGD risk through social media–based advertisements. In study 1, 9 participants performed a gaming video–based cue-reactivity task (Multimedia Appendix 1, Figure S1) to establish the association between VTA cue-reactivity and IGD symptom level [5].

Anqi Gu, Cheng Lam Chan, Xiaolei Xu, Joseph P Dexter, Benjamin Becker, Zhiying Zhao

J Med Internet Res 2025;27:e64687

Attentional Bias, Pupillometry, and Spontaneous Blink Rate: Eye Characteristic Assessment Within a Translatable Nicotine Cue Virtual Reality Paradigm

Attentional Bias, Pupillometry, and Spontaneous Blink Rate: Eye Characteristic Assessment Within a Translatable Nicotine Cue Virtual Reality Paradigm

Subjective craving before and after the VR paradigm was assessed via the Tobacco Craving Questionnaire–Short Form (TCQ-SF) [55], modified to reference participants’ preferred nicotine product (eg, e-cigarettes and tobacco cigarettes).

Kelly Elizabeth Courtney, Weichen Liu, Gianna Andrade, Jurgen Schulze, Neal Doran

JMIR Serious Games 2024;12:e54220

Effectiveness of Reducing Craving in Alcohol Use Disorder Using a Serious Game (SALIENCE): Randomized Controlled Trial

Effectiveness of Reducing Craving in Alcohol Use Disorder Using a Serious Game (SALIENCE): Randomized Controlled Trial

Craving is an important factor that contributes to relapse [4] and is considered one of the diagnostic criteria for alcohol dependence [5,6]. Craving correlates positively with the amount of alcohol consumed and can serve as a measure of relapse likelihood [7-9]. Both pharmacological and psychotherapeutic treatments are used to reduce craving and thereby prevent relapse [10-12]. Craving is triggered, among other reasons, by addiction-associated stimuli.

Antonia Weber, Yury Shevchenko, Sarah Gerhardt, Sabine Hoffmann, Falk Kiefer, Sabine Vollstädt-Klein

JMIR Form Res 2023;7:e42194

Stimulant Use Associated With Psychosocial Factors, HIV Risk, and Concurrent Hazardous Alcohol Use Among US Adults: Exploratory Cross-Sectional Questionnaire Study

Stimulant Use Associated With Psychosocial Factors, HIV Risk, and Concurrent Hazardous Alcohol Use Among US Adults: Exploratory Cross-Sectional Questionnaire Study

Scores ranged from 0 to 100, with 0 representing no craving whatsoever and 100 representing the strongest craving one has ever had. Data were analyzed using STATA (version 17; Stata Corp). Using descriptive statistics including frequencies, percentages, and depending on the distributional assumption, means, SDs, medians, and IQRs, we described the study sample overall and by subgroup (MSM vs non-MSM).

Frank Lee, Jennifer Payaal Jain, Lunthita M Duthely, Janet Ikeda, Glenn-Milo Santos

JMIR Form Res 2023;7:e45717

Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study

Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study

Nicotine craving specifically has been shown to predict lapse to cigarette smoking following cessation [5,6] and is frequently identified by individuals as an important barrier to quitting and maintaining abstinence [7]. Thus, craving represents a clinically important phenotype of nicotine addiction [8] with great potential for intervention.

Weichen Liu, Gianna Andrade, Jurgen Schulze, Neal Doran, Kelly E Courtney

JMIR Serious Games 2022;10(1):e32243

The Psychosocial Predictors and Day-Level Correlates of Substance Use Among Participants Recruited via an Online Crowdsourcing Platform in the United States: Daily Diary Study

The Psychosocial Predictors and Day-Level Correlates of Substance Use Among Participants Recruited via an Online Crowdsourcing Platform in the United States: Daily Diary Study

The relationship between craving and substance use is difficult to measure with accuracy because of the transient nature of craving [17]. Further, substance use can be episodic and is often shaped by mood and context (eg, social setting) [18]. Therefore, in order to more accurately capture the daily patterns associated with substance use, methodological approaches that overcome these challenges should be leveraged.

Jennifer Payaal P Jain, Claudine Offer, Christopher Rowe, Caitlin Turner, Carol Dawson-Rose, Thomas Hoffmann, Glenn-Milo Santos

JMIR Public Health Surveill 2021;7(4):e23872

A Smartphone-Delivered Ecological Momentary Intervention for Problem Gambling (GamblingLess: Curb Your Urge): Single-Arm Acceptability and Feasibility Trial

A Smartphone-Delivered Ecological Momentary Intervention for Problem Gambling (GamblingLess: Curb Your Urge): Single-Arm Acceptability and Feasibility Trial

Ultimately, the intervention aims to prevent cravings from transitioning into gambling episodes by identifying when a consumer is experiencing a craving (via EMA) and subsequently providing strategies to manage their craving in the moment (via EMI).

Chloe O Hawker, Stephanie S Merkouris, George J Youssef, Nicki A Dowling

J Med Internet Res 2021;23(3):e25786